Timothy W Pontz from Seattle, WA, age 57

Resumes

Timothy Pontz

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Location:

Seattle, WA

Industry:

Pharmaceuticals

Work:

Astrazeneca Jul 2008 - Aug 2013
Senior Scientist - Oncology Chemistry
Biogen Apr 1999 - Jun 2002
Associate Scientist
Pharmacopeia Aug 1998 - Apr 1999
Associate Scientist

Education:

University of Pittsburgh 1995 - 1998
Masters, Chemistry

Skills:

Organic Chemistry
Lc Ms
Drug Discovery
Medicinal Chemistry
R&D
Drug Design
Lead Change
Organic Synthesis
Nmr
Chromatography
Drug Development
Pharmaceutical Industry
Adme
Analytical Chemistry
Dmpk
Hplc
Heterocyclic Chemistry
Parallel Synthesis
Purification
Synthetic Organic Chemistry

Timothy Pontz

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Us Patents

Chemical Compounds
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US Patent:

8461170, Jun 11, 2013
Filed:

Aug 2, 2011
Appl. No.:

13/196189
Inventors:

Brian Aquila - Waltham MA, US
Victor Kamhi - Waltham MA, US
Bo Peng - Waltham MA, US
Timothy Pontz - Waltham MA, US
Jamal Carlos Saeh - Waltham MA, US
Kumar Thakur - Waltham MA, US
Bin Yang - Waltham MA, US
Assignee:

Astrazeneca AB - Sodertalje
International Classification:

A01N 43/54
A61K 31/505
US Classification:

514275, 544330, 544333, 544334
Abstract:

The present invention relates to compounds of Formula (I) and/or Formula (Ia):.

Selected Fused Heterocyclics And Uses Thereof
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US Patent:

20060041128, Feb 23, 2006
Filed:

Aug 18, 2005
Appl. No.:

11/206888
Inventors:

Brian Aquila - Waltham MA, US
Michael Block - Waltham MA, US
Audrey Davies - Waltham MA, US
Jayachandran Ezhuthachan - Waltham MA, US
Timothy Pontz - Waltham MA, US
Daniel Russell - Waltham MA, US
Maria-Elena Theoclitou - Waltham MA, US
XiaoLan Zheng - Waltham MA, US
Assignee:

AstraZeneca AB - Sodertalje
International Classification:

A61K 31/519
C07D 498/02
C07D 491/02
US Classification:

544253000, 514260100
Abstract:

This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

Enantiomers Of Selected Fused Heterocyclics And Uses Thereof
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US Patent:

20060041129, Feb 23, 2006
Filed:

Aug 18, 2005
Appl. No.:

11/207128
Inventors:

Brian Aquila - Waltham MA, US
Michael Howard Block - Waltham MA, US
Audrey Davies - Waltham MA, US
Jayachandran Ezhuthachan - Waltham MA, US
Timothy Pontz - Waltham MA, US
Daniel John Russell - Waltham MA, US
Maria-Elena Theoclitou - Waltham MA, US
XiaoLan Zheng - Waltham MA, US
Assignee:

AstraZeneca AB - Sodertalje
International Classification:

A61K 31/519
C07D 498/02
C07D 491/02
US Classification:

544253000, 514260100
Abstract:

This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

Novel Fused Heterocycles And Uses Thereof
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US Patent:

20060063751, Mar 23, 2006
Filed:

Aug 18, 2005
Appl. No.:

11/207089
Inventors:

Brian Aquila - Waltham MA, US
Michael Block - Waltham MA, US
Audrey Davies - Waltham MA, US
Jayachandran Ezhuthachan - Waltham MA, US
Sandra Filla - Brownsberg IN, US
Richard Luke - Macclesfield, GB
Timothy Pontz - Waltham MA, US
Daniel Russell - Waltham MA, US
Maria-Elena Theoclitou - Waltham MA, US
XiaoLan Zheng - Waltham MA, US
Assignee:

AstraZeneca AB - Sodertalje
International Classification:

A61K 31/513
C07D 417/02
C07D 413/02
C07D 403/02
US Classification:

514210200, 514269000, 544310000
Abstract:

This invention relates to novel compounds having the formula (I) wherein R, R, R, R, R, R, R, Rand Rare as defined in the specification and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

Pyrazoles And Methods Of Making And Using The Same
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US Patent:

20060264440, Nov 23, 2006
Filed:

Feb 12, 2004
Appl. No.:

10/545179
Inventors:

Lihong Sun - Arlington MA, US
Feng Shan - Braintree MA, US
Claudio Chuaqui - Somerville MA, US
Mark Cornebise - Watertown MA, US
Timothy Pontz - Brighton MA, US
Mary Carter - Arlington MA, US
Juswinder Singh - Ashland MA, US
Leona Ling - Winchester MA, US
Russell Petter - Stow MA, US
Assignee:

BIOGEN IDEC MA INC. - Cambridge MA
International Classification:

A61K 31/522
A61K 31/52
A61K 31/519
A61K 31/517
C07D 473/02
C07D 487/04
US Classification:

514249000, 544238000, 544235000, 544281000, 544284000, 544353000, 544277000, 544278000, 514252020, 514252040, 514263200, 514260100, 514259100, 514266200, 514266210
Abstract:

The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).

Selected Fused Heterocyclics And Uses Thereof
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US Patent:

20070249636, Oct 25, 2007
Filed:

Aug 16, 2005
Appl. No.:

11/573671
Inventors:

Brian Aquila - Marlborough MA, US
Michael Block - Sudbury MA, US
Audrey Davies - Waltham MA, US
Jayachandran Ezhuthachan - Brookline MA, US
Timothy Pontz - Cambridge MA, US
Daniel Russell - Natick MA, US
Marie-Elena Theoclitou - Cheshire, GB
XiaoLan Zheng - Waltham MA, US
Assignee:

ASTRAZENECA AB - Sodertalje
International Classification:

A61K 31/519
A61P 35/00
C07D 239/00
C07D 261/00
C07D 275/00
C07D 487/14
C07D 498/04
C07D 513/04
US Classification:

514260100, 544255000
Abstract:

This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

Azine-Carboxamides As Anti-Cancer Agents
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US Patent:

20070259849, Nov 8, 2007
Filed:

Jun 29, 2005
Appl. No.:

11/570065
Inventors:

Brian Aquila - Marlborough MA, US
Stephanos Ioannidis - Cambridge MA, US
Paul Lyne - Arlington MA, US
Timothy Pontz - Cambridge MA, US
Assignee:

ASTRAZENECA AB - Sodertalje
International Classification:

C07D 239/42
A61K 31/435
A61K 31/495
A61P 35/00
C07D 241/24
C07D 403/04
C07D 405/12
C07D 403/06
C07D 401/04
C07D 213/81
C07D 213/82
C07D 239/28
US Classification:

514211050, 514235500, 514235800, 514252140, 514255050, 514256000, 514318000, 514326000, 514354000, 514357000, 540507000, 544121000, 544124000, 544242000, 544357000, 544405000, 546193000, 546276400, 546336000, 546340000
Abstract:

The invention relates to chemical compounds, of the formula (I): or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

Chemical Compounds
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US Patent:

20080146570, Jun 19, 2008
Filed:

Jan 24, 2006
Appl. No.:

11/814246
Inventors:

Brian Aquila - Marlborough MA, US
Paul Lyne - Arlington MA, US
Timothy Pontz - Cambridge MA, US
Assignee:

ASTRAZENECA AB - Sodertalje
International Classification:

A61K 31/5377
C07D 295/00
A61K 31/506
A61P 35/00
C07D 239/00
US Classification:

5142358, 544328, 514256, 544122
Abstract:

The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof, of the formula (I): which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.