Michael J. Buckley - Ingleside IL, US Jianguo Ji - Libertyville IL, US Geoff G. Z. Zhang - Libertyville IL, US Rodger F. Henry - Wildwood IL, US Weili W. Wang - Buffalo Grove IL, US Gregory S. Wayne - Vernon Hills IL, US Wenke Li - Gurnee IL, US Timothy B. Towne - Lindenhurst IL, US Steven J. Wittenberger - Mundelein IL, US Steven M. Hannick - Highland Park IL, US Brian J. Kotecki - Oak Creek WI, US Bryan S. Macri - Gurnee IL, US Timothy A. Robbins - Grayslake IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 31/4745 C07D 487/04
US Classification:
514339, 5462767
Abstract:
The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3. 2. 0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
Michael J. Buckley - McHenry IL, US Jianguo Ji - Libertyville IL, US Geoff G. Z. Zhang - Libertyville IL, US Rodger F. Henry - Wildwood IL, US Weili W. Wang - Buffalo Grove IL, US Gregory S. Wayne - Vernon Hills IL, US Wenke Li - Gurnee IL, US Timothy B. Towne - Lindenhurst IL, US Steven J. Wittenberger - Mundelein IL, US Steven M. Hannick - Highland Park IL, US Brian J. Kotecki - Oak Creek WI, US Bryan S. Macri - Gurnee IL, US Timothy A. Robbins - Grayslake IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D 487/04
US Classification:
5462767
Abstract:
The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3. 2. 0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
Timothy A. Robbins - Gurnee IL, US Helen Zhu - South Bend IN, US Jun Shao - Mason OH, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D 277/04
US Classification:
548201, 564 74
Abstract:
This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.
Timothy Robbins - Gurnee IL, US Helen Zhu - South Bend IN, US Jun Shao - Mason OH, US
International Classification:
C12Q001/68 C 07D 2 7/333 C07C327/48
US Classification:
548530000, 564074000
Abstract:
This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.
Michael J. Buckley - McHenry IL, US Jianguo Ji - Libertyville IL, US Geoff G.Z. Zhang - Libertyville IL, US Rodger F. Henry - Wildwood IL, US Weili W. Wang - Buffalo Grove IL, US Gregory S. Wayne - Vernon Hills IL, US Wenke Li - Gurnee IL, US Timothy B. Towne - Lindenhurst IL, US Steven J. Wittenberger - Mundelein IL, US Steven M. Hannick - Highland Park IL, US Brian J. Kotecki - Oak Creek WI, US Bryan S. Macri - Gurnee IL, US Timothy A. Robbins - Grayslake IL, US
Assignee:
ABBOTT LABORATORIES - Abbott Park IL
International Classification:
A61K 31/397 A61P 25/00 A61P 25/28 C07D 401/14
US Classification:
51421016, 5462767
Abstract:
The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
Process For The Preparation Of A Substituted 2,5-Diamino-3-Hydroxyhexane
Timothy L. Stuk - Lindenhurst IL Michael S. Allen - Silver Lake WI Anthony R. Haight - Mundelein IL Francis A. Kerdesky - Grayslake IL Denton C. Langridge - Wildwood IL M. Robert Leanna - Grayslake IL Linda M. Lijewski - Milwaukee WI Laura Melcher - Deerfield IL Howard E. Morton - Gurnee IL Daniel W. Norbeck - Crystal Lake IL Daniel S. Reno - Kenosha WI Timothy A. Robbins - Gurnee IL Hing L. Sham - Mundelein IL Thomas J. Sowin - Grayslake IL Chen Zhao - Gurnee IL David Scarpetti - Baltimore MD
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07C25178 C07C22114 C07C20944
US Classification:
546 99
Abstract:
A substantially pure compound of formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl; or R. sub. 6 and R. sub. 7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R. sub. f, R. sub. g, R. sub. h and R. sub. l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; and R. sub. g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.
Process For The Preparation Of A Substituted 2.5-Diamino-3-Hydroxyhexane
Timothy L. Stuk - Lindenhurst IL Michael S. Allen - Silver Lake WI Anthony R. Haight - Mundelein IL Francis A. J. Kerdesky - Grayslake IL Denton C. Langridge - Wildwood IL M. Robert Leanna - Grayslake IL Linda M. Lijewski - Milwaukee WI Laura Melcher - Deerfield IL Howard E. Morton - Gurnee IL Daniel W. Norbeck - Crystal Lake IL Daniel S. Reno - Kenosha WI Timothy A. Robbins - Gurnee IL David Scarpetti - Evanston IL Hing L. Sham - Mundelein IL Thomas J. Sowin - Grayslake IL Chen Zhao - Gurnee IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07C26100 C07C23300 C07D20904
US Classification:
560 24
Abstract:
Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are each hydrogen or R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl or benzyl; or R. sub. 6 and R. sub.
Process For The Preparation Of A Substituted 2,5-Diamino-3-Hydroxyhexane
Timothy L. Stuk - Lindenhurst IL Anthony R. Haight - Mundelein IL Howard E. Morton - Gurnee IL Timothy A. Robbins - Gurnee IL David Scarpetti - Evanston IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07C26100 C07C23300 C07D20904
US Classification:
560 24
Abstract:
Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are each hydrogen or R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl or benzyl; or R. sub. 6 and R. sub.
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