Timothy Ray Shepherd

US Patent:

6525215, Feb 25, 2003

Filed:

Jun 21, 2001

Appl. No.:

09/885056

Inventors:

Bruce A. Dressman - Indianapolis IN
James E. Fritz - Greenwoode IN
Marlys Hammond - Pasadena CA
William J. Hornback - Indianapolis IN
Stephen W. Kaldor - Indianapolis IN
Vincent J. Kalish - San Diego CA
John E. Munroe - Indianapolis IN
Siegfried Heinz Reich - San Diego CA
John H. Tatlock - Poway CA
Timothy A. Shepherd - Indianapolis IN
Michael J. Rodriguez - Indianapolis IN

Assignee:

Agouron Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07C 6532

US Classification:

562459

Abstract:

Compounds useful as intermediates in the preparation of HIV protease inhibitors. These compounds have the following general formula:.

US Patent:

6639076, Oct 28, 2003

Filed:

Apr 17, 2001

Appl. No.:

09/762529

Inventors:

Kenneth Lee Hauser - Greencastle IN
Jeffrey Alan Dodge - Indianapolis IN
Mark Louis Heiman - Indianapolis IN
Scott Alan Jones - Indianapolis IN
Charles Arthur Alt - Greenwood IN
Henry Uhlman Bryant - Indianapolis IN
James Densmore Copp - Greenwood IN
William Harlan Gritton - Zionsville IN
Brian Stephen Muehl - Indianapolis IN
Alan David Palkowitz - Carmel IN
Andrew Michael Ratz - Greenwood IN
Gary Anthony Rhodes - Indianapolis IN
Roger Lewis Robey - Greenwood IN
Timothy Alan Shepherd - Indianapolis IN
Kenneth Jeff Thrasher - Indianapolis IN
William George Trankle - Southport IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D40112

US Classification:

546210, 514 16, 514 18, 514 19, 514222, 5142312, 514249, 514255, 514315, 514396, 514397, 530331, 546207, 546208, 546209, 546212, 5483001, 5483111, 5483147, 5483151, 5483157

Abstract:

This invention relates to novel compounds of formula I wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.

US Patent:

6639107, Oct 28, 2003

Filed:

May 14, 2002

Appl. No.:

10/130156

Inventors:

James Abraham Aikins - Pendleton IN
Edward C R Smith - Fishers IN
Timothy Alan Shepherd - Indianapolis IN
Dennis Michael Zimmerman - Zionsville IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07C30300

US Classification:

564 84, 564 79

Abstract:

The present invention provides certain cyclopentyl sulfonamide derivatives of formula (I): useful for potentiating glutamate receptor function in a mammal. It also relates to novel cyclopentyl sulfonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.

US Patent:

6653281, Nov 25, 2003

Filed:

May 24, 2001

Appl. No.:

09/763114

Inventors:

Peter Stanley Borromeo - Fishers IN
Jeffrey Daniel Cohen - Indianapolis IN
George Stuart Gregory - Fishers IN
Stacy Kay Henle - Indianapolis IN
Stephen Andrew Hitchcock - Carmel IN
Louis Nickolaus Jungheim - Indianapolis IN
Daniel Ray Mayhugh - Carmel IN
Timothy Alan Shepherd - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3812

US Classification:

514 11, 530317, 530338

Abstract:

A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal omithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.

US Patent:

6693199, Feb 17, 2004

Filed:

Nov 21, 2002

Appl. No.:

10/300638

Inventors:

Bruce A. Dressman - Indianapolis IN
James E. Fritz - Greenwoode IN
Marlys Hammond - Pasadena CA
William J. Hornback - Indianapolis IN
Stephen W. Kaldor - Indianapolis IN
Vincent J. Kalish - San Diego CA
John E. Munroe - Indianapolis IN
Siegfried Heinz Reich - San Diego CA
John H. Tatlock - Poway CA
Timothy A. Shepherd - Indianapolis IN
Michael J. Rodriguez - Indianapolis IN

Assignee:

Agouron Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07D51502

US Classification:

546114, 546115, 546146, 562459, 514307, 514300, 514301, 514302, 514303

Abstract:

A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other antiviral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

US Patent:

6703425, Mar 9, 2004

Filed:

Nov 15, 2002

Appl. No.:

10/276738

Inventors:

James Allen Knobelsdorf - Noblesville IN
Timothy Alan Shepherd - Indianapolis IN
Eric George Tromiczak - Indianapolis IN
Hamideh Zarrinmayeh - Carmel IN
Dennis Michael Zimmerman - Zionsville IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 3118

US Classification:

514605, 51425212, 514315, 514357, 514394, 514438, 514459, 514471, 514601, 544401, 544398, 546246, 546338, 5483401, 5483351, 549 75, 549426, 549495

Abstract:

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.

US Patent:

6900353, May 31, 2005

Filed:

Sep 28, 2001

Appl. No.:

10/380485

Inventors:

Buddy Eugene Cantrell - Zionsville IN, US
Timothy Alan Shepherd - Indianapolis IN, US
Hamideh Zarrinmayeh - Carmel IN, US
Dennis Michael Zimmerman - Zionsville IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K031/16
A61K031/17
A61K031/275
A61K031/44
A61K031/38

US Classification:

564 98, 546338, 549 75, 558389, 558408, 558413, 564 79, 564 82, 564 99

Abstract:

The present invention provides compounds of formula (I): useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

US Patent:

6939946, Sep 6, 2005

Filed:

Sep 30, 2003

Appl. No.:

10/676575

Inventors:

Peter Stanley Borromeo - Fishers IN, US
Jeffrey Daniel Cohen - Indianapolis IN, US
George Stuart Gregory - Fishers IN, US
Stacy Kay Henle - Indianapolis IN, US
Stephen Andrew Hitchcock - Carmel IN, US
Louis Nickolaus Jungheim - Indianapolis IN, US
Daniel Ray Mayhugh - Carmel IN, US
Timothy Alan Shepherd - Indianapolis IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07K007/50

US Classification:

530317, 530338, 530339, 530343

Abstract:

A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.