Timothy A Tully

US Patent:

6689557, Feb 10, 2004

Filed:

Jul 7, 1997

Appl. No.:

08/809917

Inventors:

Timothy P. Tully - Cold Spring Harbor NY
Jerry Chi-Ping Yin - Huntington NY

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY

International Classification:

C12Q 100

US Classification:

435 4, 536 231, 436 63, 424 91

Abstract:

Methods of modulating long term memory, identifying a substance capable of affecting long term memory and assessing the effect of a drug on long term memory are disclosed.

US Patent:

6890516, May 10, 2005

Filed:

Oct 14, 1999

Appl. No.:

09/419371

Inventors:

Timothy P. Tully - Cold Spring Harbor NY, US
Jerry Chi-Ping Yin - Huntington NY, US

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY

International Classification:

A61K049/00
A61K038/00
G01N031/00
G01N033/53
C12Q001/68

US Classification:

424 92, 424 91, 436 15, 435 6, 435 71, 435 72, 435 721, 514 12, 514 44

Abstract:

Methods of assessing the effect of a drug on long term memory and for screening a pharmaceutical agent for its ability to modulate long term memory are disclosed.

US Patent:

7005256, Feb 28, 2006

Filed:

Mar 10, 2000

Appl. No.:

09/523066

Inventors:

Timothy P. Tully - Cold Spring Harbor NY, US
Joshua I. Dubnau - Huntington Station NY, US
Michael Davis - Stone Mountain GA, US
Jan Mous - Giebenach, CH
Ulrich Certa - Allschwil, CH

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
Emory University - Atlanta GA
Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C12Q 1/68
C12M 1/00
C07H 21/04

US Classification:

435 6, 435 911, 4352831, 4352872, 536 231, 536 2431

Abstract:

The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during transcription-dependent memory formation but not during transcription-independent memory formation. A statistical analysis of the gene chip identification output yields a set of genes that are involved in transcription-dependent memory formation.

US Patent:

7358049, Apr 15, 2008

Filed:

Aug 8, 2005

Appl. No.:

11/199563

Inventors:

Timothy P. Tully - Cold Spring Harbor NY, US
Joshua I. Dubnau - Huntington Station NY, US
Michael Davis - Stone Mountain GA, US
Jan Mous - Giebenach, CH
Ulrich Certa - Allschwil, CH

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
Emory University - Atlanta GA
Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C12Q 1/68
C12M 1/00
C07H 21/04

US Classification:

435 6, 435 911, 4352872, 536 231, 536 2431

Abstract:

The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during transcription-dependent memory formation but not during transcription-independent memory formation. A statistical analysis of the gene chip identification output yields a set of genes that are involved in transcription-dependent memory formation.

US Patent:

7572434, Aug 11, 2009

Filed:

Feb 25, 2005

Appl. No.:

11/066125

Inventors:

Timothy P. Tully - Cold Spring Harbor NY, US
Jerry Chi-Ping Yin - Madison WI, US

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY

International Classification:

A61K 49/00
A61K 38/00
G01N 31/00
G01N 33/53
C12Q 1/68

US Classification:

424 92, 424 91, 435 6, 435 71, 435 72, 435 721, 514 12, 514 44, 436 15

Abstract:

Methods of assessing the effect of a drug on long term memory and for screening a pharmaceutical agent for its ability to modulate long term memory are disclosed.

US Patent:

7622257, Nov 24, 2009

Filed:

Jan 31, 2008

Appl. No.:

12/023870

Inventors:

Timothy P. Tully - Cold Spring Harbor NY, US
Roderick E. M. Scott - New York NY, US
Rusiko Bourtchouladze - New York NY, US

Assignee:

Helicon Therapeutics, Inc. - San Diego CA

International Classification:

C12Q 1/68
C12N 5/00

US Classification:

435 6, 435325

Abstract:

The present invention provides cell-based screening methods for identifying pharmaceutical agents which are capable of modulating (have the ability to modulate) STAUFEN function by screening for STAUFEN function.

US Patent:

7868015, Jan 11, 2011

Filed:

Oct 7, 2005

Appl. No.:

11/246005

Inventors:

Timothy P. Tully - Cold Spring Harbor NY, US
Filippo Cavalieri - Forest Hills NY, US
Rusiko Bourtchouladze - New York NY, US

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY

International Classification:

A01N 43/40
A01N 43/42
A61K 31/435
A61K 31/44

US Classification:

514277, 514279, 514290

Abstract:

The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.

US Patent:

7947731, May 24, 2011

Filed:

Aug 10, 2001

Appl. No.:

09/927914

Inventors:

Timothy P. Tully - Cold Spring Harbor NY, US
Filippo Cavalieri - Forest Hills NY, US

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY

International Classification:

A01N 43/64
A01N 43/38
A01N 43/36
A61K 31/41
A61K 31/40

US Classification:

514424, 514359, 514408, 514410

Abstract:

The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.