Tingmin Wang

US Patent:

6407135, Jun 18, 2002

Filed:

Dec 3, 1999

Appl. No.:

09/453608

Inventors:

Ching-San Lai - Encinitas CA
Tingmin Wang - San Marcos CA

Assignee:

Medinox, Inc. - San Diego CA

International Classification:

C07D20704

US Classification:

514423, 514 2, 514514, 530402, 548565, 548573

Abstract:

In accordance with the present invention, there are provided conjugates of nitric oxide scavengers (e. g. , dithiocarbamates, or âDCâ) and pharmacologically active agents (e. g. , NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e. g. , anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein. In addition, invention conjugates are more effective than unmodified pharmacologically active agents because cells and tissues contacted by the pharmacologically active agent(s) are protected from the potentially damaging effects of nitric oxide overproduction induced thereby as a result of the co-production of nitric oxide scavenger (e. g. , dithiocarbamate), in addition to free pharmacologically active agent, when invention conjugate is cleaved.

US Patent:

6414135, Jul 2, 2002

Filed:

Jul 7, 1999

Appl. No.:

09/349035

Inventors:

Phillip Dan Cook - Fallbrook CA
Haoyun An - Carlsbad CA
Tingmin Wang - San Marcos CA
Muthiah Manoharan - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2100

US Classification:

536 253

Abstract:

The present invention is directed to nucleoside monomers wherein the 3â-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylenephosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.

US Patent:

6429223, Aug 6, 2002

Filed:

Nov 17, 2000

Appl. No.:

09/715767

Inventors:

Ching-San Lai - Encinitas CA
Tingmin Wang - San Marcos CA

Assignee:

Medinox, Inc. - San Diego CA

International Classification:

A61K 3148

US Classification:

514411, 514415, 514424, 514517, 514532, 514533, 514534

Abstract:

In accordance with the present invention, there are provided modified forms of nonsteroidal anti-inflammatory drugs (NSAIDs). Modified NSAIDs according to the invention provide a new class of anti-inflammatory agent which provide the therapeutic benefits of NSAIDs while causing a much lower incidence of side-effects then typically observed with such agents.

US Patent:

6620813, Sep 16, 2003

Filed:

Jun 21, 2002

Appl. No.:

10/177683

Inventors:

Tingmin Wang - San Marcos CA
Ching-San Lai - Carlsbad CA

Assignee:

Medinox, Inc. - San Diego CA

International Classification:

A61K 3153

US Classification:

514243, 514369, 514420, 514507, 514602, 514603, 514604, 514605, 544183, 548182, 548207, 560 38, 560 56

Abstract:

In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e. g. , as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and 5-lipoxygenase (5-LO); as anticancer agents (through promoting apoptosis and/or inhibiting the matrix metalloproteinases (MMPs)), and the like. Invention compounds comprise a non-steroidal anti-inflammatory agent (NSAID), covalently linked to a hydroxamate. Invention compounds are useful for a variety of applications, such as, for example, treating inflammation and inflammation-related conditions; reducing the side effects associated with administration of anti-inflammatory agents; promoting apoptosis; inhibiting matrix metalloproteinases; and the like.

US Patent:

6710086, Mar 23, 2004

Filed:

Feb 25, 2000

Appl. No.:

09/515043

Inventors:

Ching-San Lai - Encinitas CA
Tingmin Wang - San Marcos CA
Vassil P. Vassilev - San Diego CA

Assignee:

Medinox, Inc. - San Diego CA

International Classification:

A61K 3116

US Classification:

514599, 514423, 514514, 514706, 558235

Abstract:

In accordance with the present invention, there are provided conjugates of dithiocarbamates âDCâ) and pharmacologically active agents (e. g. , NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e. g. , anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein.

US Patent:

RE41151, Feb 23, 2010

Filed:

Aug 20, 2008

Appl. No.:

12/194940

Inventors:

Ching-San Lai - Encinitas CA, US
Tingmin Wang - San Marcos CA, US

Assignee:

Medinox, Inc. - Carlsbad CA

International Classification:

A61K 31/48
A61K 31/405
A61K 31/255
A61K 31/40
A61K 31/34
C07C 69/66
C07C 69/67
C07C 69/612

US Classification:

560 56, 514411, 514415, 514424, 514517, 514532, 514533, 514534, 5483667, 5483671, 548449, 548486, 558 52, 558 56, 560 60, 560 73, 564 92, 564167, 564168, 564160, 564163

Abstract:

In accordance with the present invention, there are provided normal modified forms of nonsteroidal anti-inflammatory drugs. Modified NSAIDs according to the invention provide a new class of anti-inflammatory agent which provide the therapeutic benefits of NSAIDs while causing a much lower incidence of side-effects then typically observed with such agents.

US Patent:

7928085, Apr 19, 2011

Filed:

Oct 16, 2007

Appl. No.:

11/873202

Inventors:

David Kucera - Del Mar CA, US
Gregory J. Haley - San Diego CA, US
Erik J. Rueden - San Diego CA, US
Tingmin Wang - San Diego CA, US
Fritz Blatter - Reinach BL, DE
Martin Viertelhaus - Basel, DE

Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07H 19/00
A61K 31/70
A01N 43/04

US Classification:

514 45, 536 272

Abstract:

The present disclosure relates to p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and to its use in treating conditions such as viral infections, tumors, and cancer. Also disclosed is a method of preparing the p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and methods for producing furanose compounds which are useful intermediates in the preparation of pharmaceutical compounds such as p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.

US Patent:

8193342, Jun 5, 2012

Filed:

Mar 23, 2011

Appl. No.:

13/069426

Inventors:

David Kucera - Del Mar CA, US
Gregory J. Haley - San Diego CA, US
Erik J. Rueden - Belmont CA, US
Tingmin Wang - San Diego CA, US

Assignee:

Anadys Pharmaceuticals, Inc. - San Diego CA

International Classification:

C07H 1/08

US Classification:

536124

Abstract:

The present disclosure relates to methods for preparing furanose compounds of Formula (3), which are useful as intermediates in the preparation of a p-toluene sulfonic acid salt of 5-amino-3-(2′-O-acetyl-3′-deoxy-beta-D-ribofuranosyl)-3H-thiazolo[4,5-d]pyrimidin-2-one and the like.