Todd Randall Allen

US Patent:

20030198941, Oct 23, 2003

Filed:

Apr 9, 2001

Appl. No.:

09/829228

Inventors:

David Watkins - Arena WI, US
Todd Allen - Madison WI, US
David O'Connor - Madison WI, US
Bianca Mothe - Madison WI, US
Thorsten Vogel - Madison WI, US
Helen Horton - Madison WI, US

International Classification:

C12Q001/70
A61K039/21

US Classification:

435/005000

Abstract:

A method of identifying at least one CTL-inducing epitope from HIV protein is disclosed. In one embodiment, the method comprises the steps of (a) examining the nucleic acid sequence encoding at least one HIV protein from at least one HIV-infected patient, wherein the sequence encoding the expressed protein is examined in the first six months after infection, to identify at least one region of the HIV protein that is variable as compared to the sequence of the protein at an earlier time point in infection, wherein the variable region indicates a CTL-inducing epitope, and (b) confirming that an immune response directed against the CTL-inducing epitope is capable of selecting for viral escape variants during the acute or periacute phase of HIV infection is of high avidity.

US Patent:

20190131021, May 2, 2019

Filed:

Mar 4, 2014

Appl. No.:

14/196883

Inventors:

- Hanover NH, US
Philipp Hunger - Pittsburgh PA, US
Todd Allen - Idaho Falls ID, US

Assignee:

The Trustees of Dartmouth College - Hanover NH

International Classification:

G21C 3/04

Abstract:

A multiphase composite, formed by freeze-casting, lyophilization, and sintering, has sintered particles forming a scaffold having at least one region of aligned porosity; and a second phase formed in pores of the scaffold. In a particular embodiment, the second phase is a nuclear fuel, in another, the first phase is a nuclear fuel, and in others, both phases are nuclear fuels. In some embodiments, the first phase is a ceramic, and in other embodiments a metal such as stainless steel. In other embodiments, the second phase is a metal, and in other embodiments a ceramic. In some embodiments the second phase is positioned in a subset of pores of the scaffold, at least some additional pores being filled with a third phase. In embodiments, the second phase is also sintered.