Todd Alan Ciche from Chesterfield, MO, age 53

Resumes

Fellow And Microbiologist

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Location:

14320 Strawbridge Ct, Chesterfield, MO 63017

Industry:

Chemicals

Work:

Michigan State University
Assistant Professor

Education:

University of Wisconsin - Madison 1994 - 2000
Doctorates, Doctor of Philosophy, Philosophy University of Wisconsin - Madison 1990 - 1994
Bachelors, Bachelor of Science

Skills:

Molecular Biology
Science
Genetics
Research
Biochemistry
Pcr
Teaching
Western Blotting
Cell Culture
Higher Education
Microbiology
Polymerase Chain Reaction
Experimental Design
University Teaching
Microscopy
Phylogenetics
Life Sciences
Statistics
Animal Models

Us Patents

Novel Insect Inhibitory Proteins
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US Patent:

20220248686, Aug 11, 2022
Filed:

Jan 26, 2022
Appl. No.:

17/584677
Inventors:

- St. Louis MO, US
Catherine A. Chay - Ballwin MO, US
Danqi Chen - Ballwin MO, US
Todd A. Ciche - San Diego CA, US
Arlene R. Howe - Ckarkson Valley MO, US
Jennifer L. Lutke - Ballwin MO, US
Barbana E. Wiggins - Chesterfield MO, US
Yuanji Zhang - Weldon Spring MO, US
International Classification:

A01N 63/25
C12N 15/70
C12Q 1/6895
C07K 14/195
C12N 15/82
Abstract:

Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3 pesticidal proteins are also provided. Also disclosed are methods and compositions to improve the insecticidal activity of a pesticidal protein against an insect pest species. Further disclosed are method and compositions to reduce expression of a pesticidal protein in the reproductive tissues of a transgenic plant.

Novel Insect Inhibitory Proteins
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US Patent:

20220235369, Jul 28, 2022
Filed:

Jan 13, 2022
Appl. No.:

17/575318
Inventors:

- St. Louis MO, US
Catherine A. Chay - Ballwin MO, US
Todd A. Ciche - San Diego CA, US
Stanislaw Flainski - Ballwin MO, US
Arlene R. Howe - Clarkson Valley MO, US
Krishnakumar Sridharan - St. Louis MO, US
International Classification:

C12N 15/82
A01N 37/46
C07K 14/195
C07K 14/32
A01N 63/50
Abstract:

A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran and Lepidopteran species pests using the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins are also provided.

Novel Insect Inhibitory Proteins
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US Patent:

20220220160, Jul 14, 2022
Filed:

Dec 23, 2021
Appl. No.:

17/561332
Inventors:

- St. Louis MO, US
Todd A. Ciche - San Diego CA, US
Arlene R. Howe - Clarkson Valley MO, US
Stephanie C. Waldheuser - St. Louis MO, US
Kimberly M. Wegener - St. Louis MO, US
International Classification:

C07K 14/325
A01N 63/50
A01P 7/04
C12N 15/82
Abstract:

Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC13085 and TIC13087. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC13085 and TIC13087 pesticidal proteins are also provided.

Novel Insect Inhibitory Proteins
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US Patent:

20230108260, Apr 6, 2023
Filed:

Oct 4, 2022
Appl. No.:

17/938016
Inventors:

- St. Louis MO, US
Catherine A. Chay - Ballwin MO, US
Todd A. Ciche - San Diego CA, US
Stanislaw Flasinski - Ballwin MO, US
Arlene R Howe - Clarkson Valley MO, US
Jason S. Milligan - Troy IL, US
James K. Roberts - Chesterfield MO, US
Yong Yin - Creve Coeur MO, US
International Classification:

C12N 15/82
Abstract:

Pesticidal proteins exhibiting toxic activity against Coleopteran, Lepidopteran, Hemipteran, and Thysanopteran pest species are disclosed, and include, but are not limited to, TIC6280, TIC6281, TIC6282, TIC6283, TIC8808, TIC9480, TIC9257, TIC7106, TIC7017, TIC7107, TIC7108, TIC7109, TIC7110, TIC7111, TIC7589, TIC9258, and TIC9259. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the pesticidal proteins provided. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran, Coleopteran, Hemipteran and Thysanopteran infestation are provided which contain recombinant nucleic acid sequences encoding the disclosed pesticidal proteins. Methods for detecting the presence of the recombinant nucleic acid sequences or the protein of the present invention in a biological sample, and methods of controlling Coleopteran, Lepidopteran, Hemipteran, and Thysanopteran species pests using the disclosed pesticidal proteins are also provided.

Novel Insect Inhibitory Proteins
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US Patent:

20210246464, Aug 12, 2021
Filed:

Apr 27, 2021
Appl. No.:

17/242049
Inventors:

- St. Louis MO, US
Catherine A. Chay - Ballwin MO, US
Todd A. Ciche - Glencoe MO, US
Uma R. Kesanapalli - Chesterfield MO, US
Jennifer L. Lutke - Ballwin MO, US
Assignee:

Monsanto Technology LLC - St. Louis MO
International Classification:

C12N 15/82
C12Q 1/6895
A01N 63/50
A01N 37/46
G01N 33/53
Abstract:

Pesticidal proteins exhibiting toxic activity against pest species are disclosed, and include, but are not limited to, TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling species pests using any of the TIC6757, TIC6757PL, TIC7472, TIC7472PL, TIC7473, and TIC7473PL pesticidal proteins are also provided.

Novel Insect Inhibitory Proteins
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US Patent:

20200370066, Nov 26, 2020
Filed:

Jun 8, 2020
Appl. No.:

16/895921
Inventors:

- St. Louis MO, US
Catherine A. Chay - Ballwin MO, US
Todd A. Ciche - San Diego CA, US
Stanislaw Flasinski - Ballwin MO, US
Arlene R. Howe - Clarkson Valley MO, US
Jason S. Milligan - Troy IL, US
James K. Roberts - Chesterfield MO, US
Yong Yin - Creve Coeur MO, US
International Classification:

C12N 15/82
Abstract:

Pesticidal proteins exhibiting toxic activity against Coleopteran, Lepidopteran, Hemipteran, and Thysanopteran pest species are disclosed, and include, but are not limited to, TIC6280, TIC6281, TIC6282, TIC6283, TIC8808, TIC9480, TIC9257, TIC7106, TIC7017, TIC7107, TIC7108, TIC7109, TIC7110, TIC7111, TIC7589, TIC9258, and TIC9259. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the pesticidal proteins provided. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran, Coleopteran, Hemipteran and Thysanopteran infestation are provided which contain recombinant nucleic acid sequences encoding the disclosed pesticidal proteins. Methods for detecting the presence of the recombinant nucleic acid sequences or the protein of the present invention in a biological sample, and methods of controlling Coleopteran, Lepidopteran, Hemipteran, and Thysanopteran species pests using the disclosed pesticidal proteins are also provided.

Methods For Detecting Microbes
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US Patent:

20200308632, Oct 1, 2020
Filed:

Aug 29, 2018
Appl. No.:

16/642339
Inventors:

- St. Louis MO, US
Todd A. Ciche - Chesterfield MO, US
Julia L. Stevens - St. Louis MO, US
Keith H. Turner - St. Louis MO, US
International Classification:

C12Q 1/689
C12Q 1/18
A01N 63/27
A01N 63/23
A01N 63/36
Abstract:

Methods useful in detecting viable microbes in an agricultural composition are provided. Certain embodiments relate to methods in which a sample of an agricultural composition is obtained, and an amount of at least one pre-rRNA from at least one microbe is detected. The detected pre-rRNA from an agricultural sample may be compared with the amount of pre-rRNA from a control sample to determine the presence of a viable microbe.

Novel Insect Inhibitory Proteins
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US Patent:

20200229445, Jul 23, 2020
Filed:

Jan 21, 2020
Appl. No.:

16/748392
Inventors:

- St. Louis MO, US
Catherine A Chay - Ballwin MO, US
Danqi Chen - Ballwin MO, US
Todd A. Ciche - San Diego CA, US
Arlene R. Howe - Clarkson Valley MO, US
Jennifer L. Lutke - Ballwin MO, US
Barbara E. Wiggins - Chesterfield MO, US
Yuanji Zhang - Chesterfield MO, US
International Classification:

A01N 63/25
C12N 15/70
C12N 15/82
C12Q 1/6895
C07K 14/195
Abstract:

Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding one or more of the disclosed pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Lepidopteran species pests using any of the TIC7941, TIC7941PL_1, TIC7941PL_2, and TIC7941PL_3 pesticidal proteins are also provided. Also disclosed are methods and compositions to improve the insecticidal activity of a pesticidal protein against an insect pest species. Further disclosed are method and compositions to reduce expression of a pesticidal protein in the reproductive tissues of a transgenic plant.