Todd M Covey

US Patent:

20020009776, Jan 24, 2002

Filed:

Mar 22, 2001

Appl. No.:

09/815108

Inventors:

Christiaan Saris - Newbury Park CA, US
Sharon Mu - Thousand Oaks CA, US
Min Xia - Newbury Park CA, US
Thomas Boone - Newbury Park CA, US
Todd Covey - Moorpark CA, US

Assignee:

Amgen, Inc.

International Classification:

C12P021/02
C07K014/705
G01N033/53
C12N005/06
C07H021/04

US Classification:

435/069100, 435/007100, 435/325000, 530/350000, 536/023500, 530/388220, 435/334000

Abstract:

The present invention provides Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGFR-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with FGFR-L polypeptides.

US Patent:

20030087384, May 8, 2003

Filed:

Aug 28, 2002

Appl. No.:

10/229584

Inventors:

Christiaan Saris - Newbury Park CA, US
Sharon Mu - Thousand Oaks CA, US
Min Xia - Newbury Park CA, US
Thomas Boone - Newbury Park CA, US
Todd Covey - Moorpark CA, US

Assignee:

Amgen Inc. A Corporation of the State of Delaware

International Classification:

C07K014/71
C07H021/04
C12P021/02
C12N005/06

US Classification:

435/069100, 435/320100, 435/325000, 530/350000, 536/023500

Abstract:

The present invention provides Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGFR-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with FGFR-L polypeptides.

US Patent:

20080044859, Feb 21, 2008

Filed:

Aug 13, 2007

Appl. No.:

11/838136

Inventors:

Christiaan Saris - Newbury Park CA, US
Sharon Mu - Thousand Oaks CA, US
Min Xia - Newbury Park CA, US
Thomas Boone - Newbury Park CA, US
Todd Covey - Moorpark CA, US

Assignee:

AMGEN, INC. - Thousand Oaks CA

International Classification:

C12P 21/00
C07H 21/00
C12N 1/00
C12N 15/63
C12N 5/00

US Classification:

435071100, 435243000, 435320100, 435325000, 536023500

Abstract:

The present invention provides Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGFR-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with FGFR-L, polypeptides.

US Patent:

20090269800, Oct 29, 2009

Filed:

Apr 29, 2009

Appl. No.:

12/432239

Inventors:

Todd COVEY - San Carlos CA, US
Garry P. Nolan - San Francisco CA, US

International Classification:

C12Q 1/02
C12M 1/00

US Classification:

435 29, 4353091, 4352872, 4352871

Abstract:

A cell analysis device and method is described which enables the user to efficiently treat cells in a sample. The cells can be treated with reagents at a time and place proximate to collection and may be handled in a automated or semi automated fashion.

US Patent:

20100030719, Feb 4, 2010

Filed:

Aug 10, 2009

Appl. No.:

12/538643

Inventors:

Todd M. Covey - San Carlos CA, US
Erik Evensen - Foster City CA, US
Santosh K. Putta - Foster City CA, US

International Classification:

G06N 5/02
G06F 17/30

US Classification:

706 48, 7071041, 707E17044

Abstract:

In one embodiment, one or more processor-readable media can be configured to store code representing instructions that when executed by one or more processors can cause the one or more processors to select a first relationship rule based on a first combination of parameters including a first parameter, and based on a hierarchical position of the first parameter within a hierarchical structure of a set of parameters from a biological category. A first statistical value can be defined based on a plurality of test values and based on the first relationship rule. A second statistical value can be defined based on a second relationship rule and based on a second combination of parameters. The second relationship rule can be selected based on a hierarchical position of the second parameter within the hierarchical structure of the set of parameters.

US Patent:

20100042351, Feb 18, 2010

Filed:

Jul 10, 2009

Appl. No.:

12/501274

Inventors:

Todd M. Covey - San Carlos CA, US
Darwin A. Farrow - Castro Valley CA, US
Barton J. Friedland - San Francisco CA, US
Helen Francis-Lang - Devon, GB
Malcolm Francis-Lang - , US
Justin W. Mccarthy - San Francisco CA, US
Santosh K. Putta - Foster City CA, US
David B. Rosen - Mountain View CA, US
David M. Soper - San Francisco CA, US
David C. Spellmeyer - Oakland CA, US

International Classification:

G06F 19/00

US Classification:

702108

Abstract:

In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.

US Patent:

20100105074, Apr 29, 2010

Filed:

Oct 27, 2009

Appl. No.:

12/606869

Inventors:

Todd Covey - San Carlos CA, US
Adam Palazzo - San Francisco CA, US
Norman Purvis - Franklin TN, US
James Cordiero - Redwood City CA, US
David Rosen - Mountain View CA, US

Assignee:

Nodality, Inc. a Delaware Corporation - South San Francisco CA

International Classification:

G01N 33/53
G01N 33/48

US Classification:

435 71, 422 63, 422 67, 422 61, 436501

Abstract:

The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer.

US Patent:

20100209929, Aug 19, 2010

Filed:

Jan 14, 2010

Appl. No.:

12/687873

Inventors:

Wendy J. Fantl - San Francisco CA, US
Alessandra Casano - Redwood City CA, US
Todd Covey - San Carlos CA, US

Assignee:

Nodality, Inc., A Delaware Corporation - South San Francisco CA

International Classification:

C12Q 1/68
C12Q 1/02

US Classification:

435 6, 435 29

Abstract:

An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds.