Todd M Covey

US Patent:

20090269800, Oct 29, 2009

Filed:

Apr 29, 2009

Appl. No.:

12/432239

Inventors:

Todd COVEY - San Carlos CA, US
Garry P. Nolan - San Francisco CA, US

International Classification:

C12Q 1/02
C12M 1/00

US Classification:

435 29, 4353091, 4352872, 4352871

Abstract:

A cell analysis device and method is described which enables the user to efficiently treat cells in a sample. The cells can be treated with reagents at a time and place proximate to collection and may be handled in a automated or semi automated fashion.

US Patent:

20100030719, Feb 4, 2010

Filed:

Aug 10, 2009

Appl. No.:

12/538643

Inventors:

Todd M. Covey - San Carlos CA, US
Erik Evensen - Foster City CA, US
Santosh K. Putta - Foster City CA, US

International Classification:

G06N 5/02
G06F 17/30

US Classification:

706 48, 7071041, 707E17044

Abstract:

In one embodiment, one or more processor-readable media can be configured to store code representing instructions that when executed by one or more processors can cause the one or more processors to select a first relationship rule based on a first combination of parameters including a first parameter, and based on a hierarchical position of the first parameter within a hierarchical structure of a set of parameters from a biological category. A first statistical value can be defined based on a plurality of test values and based on the first relationship rule. A second statistical value can be defined based on a second relationship rule and based on a second combination of parameters. The second relationship rule can be selected based on a hierarchical position of the second parameter within the hierarchical structure of the set of parameters.

US Patent:

20100042351, Feb 18, 2010

Filed:

Jul 10, 2009

Appl. No.:

12/501274

Inventors:

Todd M. Covey - San Carlos CA, US
Darwin A. Farrow - Castro Valley CA, US
Barton J. Friedland - San Francisco CA, US
Helen Francis-Lang - Devon, GB
Malcolm Francis-Lang - , US
Justin W. Mccarthy - San Francisco CA, US
Santosh K. Putta - Foster City CA, US
David B. Rosen - Mountain View CA, US
David M. Soper - San Francisco CA, US
David C. Spellmeyer - Oakland CA, US

International Classification:

G06F 19/00

US Classification:

702108

Abstract:

In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.

US Patent:

20100105074, Apr 29, 2010

Filed:

Oct 27, 2009

Appl. No.:

12/606869

Inventors:

Todd Covey - San Carlos CA, US
Adam Palazzo - San Francisco CA, US
Norman Purvis - Franklin TN, US
James Cordiero - Redwood City CA, US
David Rosen - Mountain View CA, US

Assignee:

Nodality, Inc. a Delaware Corporation - South San Francisco CA

International Classification:

G01N 33/53
G01N 33/48

US Classification:

435 71, 422 63, 422 67, 422 61, 436501

Abstract:

The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer.

US Patent:

20120215481, Aug 23, 2012

Filed:

Feb 17, 2012

Appl. No.:

13/399489

Inventors:

Todd M. Covey - San Carlos CA, US
Darwin A. Farrow - Castro Valley CA, US
Barton J. Friedland - San Francisco CA, US
Helen Francis-Lang - Deven, GB
Malcolm Francis-Lang - Devon, GB
Justin W. Mccarthy - San Francisco CA, US
Santosh K. Putta - Foster City CA, US
David B. Rosen - Mountain View CA, US
David M. Soper - San Francisco CA, US
David C. Spellmeyer - Oakland CA, US

Assignee:

Nodality, Inc. - South San Francisco CA

International Classification:

G06F 19/00

US Classification:

702123

Abstract:

In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.

US Patent:

20140031308, Jan 30, 2014

Filed:

Sep 8, 2011

Appl. No.:

13/821539

Inventors:

Longo Diane - Foster City CA, US
Todd M. Covey - San Carlos CA, US
David M. Soper - San Francisco CA, US
Garry P. Nolan - San Francisco CA, US
Alessandra Cesano - Redwood city CA, US

International Classification:

G01N 33/50
G06F 19/12

US Classification:

514 43, 435 29, 435 721, 703 11, 703 2

Abstract:

Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample.

US Patent:

20210322408, Oct 21, 2021

Filed:

Apr 16, 2021

Appl. No.:

17/232254

Inventors:

- OSS, NL
Todd Covey - San Carlos CA, US
Allard Kaptein - Zaltbommel, NL
Dave Johnson - Aptos CA, US
Jay Stamatis - San Mateo CA, US
Cecile M. Krejsa - Seattle WA, US
John Gregory Slatter - Seattle WA, US

International Classification:

A61K 31/4985
A61K 31/454
A61K 31/522
A61K 31/00
A61K 9/50
A61K 9/20
A61K 9/16
A61K 9/00
A61K 31/519

Abstract:

In an embodiment, therapeutic methods and uses of Bruton's Tyrosine Kinase (BTK) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for a BTK inhibitor for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described.

US Patent:

20190376971, Dec 12, 2019

Filed:

Jan 19, 2018

Appl. No.:

16/477395

Inventors:

- Oss, NL
Allard Kaptein - Zaltbommel, NL
Saskia Verkaik - Macharen, NL
Dennis Demont - Oss, NL
Todd Covey - San Carlos CA, US
Bas Van De Kar - Oss, NL
Bart Van Lith - Uden, NL
Michael Gulrajani - San Carlos CA, US

International Classification:

G01N 33/573
C07D 519/00

Abstract:

In some embodiments, the invention relates to compositions, methods, and kits for assessment of drug target occupancy in Bruton's tyrosine kinase (BTK) in a selective and sensitive manner for use with BTK inhibitor therapy in the treatment of Bruton's tyrosine kinase (BTK) mediated disorders, including cancers, inflammatory diseases, and immune and autoimmune diseases.