The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of compositions comprising an effective amount of bone sialoprotein to enhance the repair of damaged or diseased bone.
Dale R. Peterson - Carmel IN Todd P. Glancy - Fairmount IN
Assignee:
DePuy Orthopaedics, Inc. - Warsaw IN
International Classification:
A61K 910
US Classification:
424486, 424426
Abstract:
Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0. 01 to about 500 mg/mL at about 25Â C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
Dale R. Peterson - Carmel IN, US Todd P. Glancy - Fairmount IN, US
Assignee:
DePuy Orthopaedics, Inc. - Warsaw IN
International Classification:
A61K009/10 A61K047/34 A61K031/765 C08G063/08
US Classification:
424486, 424 7837, 156332, 5283184, 528931
Abstract:
Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0. 01 to about 500 mg/mL at about 25 C. and adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
Dale R. Peterson - Carmel IN, US Todd P. Glancy - Fairmount IN, US
Assignee:
DePuy Products, Inc. - Warsaw IN
International Classification:
A61K 47/34
US Classification:
424486, 424426
Abstract:
Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0. 01 to about 500 mg/mL at about 25 C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
Use Of Untranslated Region Of Osmotin Gene To Enhance Transgene Expression In Plants
Donald J. Merlo - Carmel IN, US Dong Liu - Carmel IN, US Stephanie L. Burton - Indianapolis IN, US Todd P. Glancy - Fairmount IN, US
Assignee:
Dow AgroSciences LLC - Indianapolis IN
International Classification:
C07H 21/04 C12N 15/00 C12N 15/113 C12N 15/63
US Classification:
536 241, 536 231, 800278, 800279, 4353201
Abstract:
The present invention provides methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 5′ and 3′ untranslated regions of genes encoding osmotin proteins and engineered to flank respective portions of a selected coding region of a vector. The vector construct may be introduced into plants and/or plant tissues through conventional procedures, resulting in enhanced expression of the selected coding region. In a preferred embodiment, the selected coding region is a chimeric gene or gene fragment expressing one or more proteins known to impart a level of insecticidal activity to a transgenic plant and/or plant tissue.
Use Of Untranslated Region Of Osmotin Gene To Enhance Transgene Expression In Plants
Donald Joseph Merio - Carmel IN, US Dong Liu - Carmel IN, US Stephanie Love Burton - Indianapolis IN, US Todd Philip Glancy - Fairmount IN, US
Assignee:
Dow AgroSciences LLC - Indianapolis IN
International Classification:
C07H 21/04 C12N 15/00 C12N 15/113 C12N 15/63
US Classification:
536 241, 536 231, 800278, 800279, 4353201
Abstract:
The present invention provides methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 5′ and 3′ untranslated regions of genes encoding osmotin proteins and engineered to flank respective portions of a selected coding region of a vector. The vector construct may be introduced into plants and/or plant tissues through conventional procedures, resulting in enhanced expression of the selected coding region. In a preferred embodiment, the selected coding region is a chimeric gene or gene fragment expressing one or more proteins known to impart a level of insecticidal activity to a transgenic plant and/or plant tissue.
Use Of Untranslated Region Of Osmotin Gene To Enhance Transgene Expression In Plants
Donald Merlo - Carmel IN, US Dong Liu - Carmel IN, US Stephanie Burton - Indianapolis IN, US Todd Glancy - Fairmount IN, US
International Classification:
A01H001/00 C12N015/82 C07H021/04 C12Q001/68
US Classification:
800278000, 536023200, 435468000
Abstract:
The present invention provides methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 5′ and 3′ untranslated regions of genes encoding osmotin proteins and engineered to flank respective portions of a selected coding region of a vector. The vector construct may be introduced into plants and/or plant tissues through conventional procedures, resulting in enhanced expression of the selected coding region. In a preferred embodiment, the selected coding region is a chimeric gene or gene fragment expressing one or more proteins known to impart a level of insecticidal activity to a transgenic plant and/or plant tissue.
Plant Production Of Immunoglobulins With Reduced Fucosylation
Kristen Briggs - Del Mar CA, US Todd Glancy - Indianapolis IN, US Mich Hein - Chicago IL, US Andrew Hiatt - San Diego CA, US Anton Karnoup - Midland MI, US W. H. Anderson - Midland MI, US Dayakar Pareddy - Indianapolis IN, US Joseph Petolino - Indianapolis IN, US Beth Rubin-Wilson - Indianapolis IN, US Doug Taylor - Midland MI, US Jean Roberts - Indianapolis IN, US
This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g., leaves, seeds, tubers, etc.); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.
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