Peng Cho Tang - Moraga CA Todd A. Miller - Bend OR Xiaoyuan Li - San Jose CA Ruofei Zhang - Foster City CA Jinrong Cui - Albany CA Ping Huang - Mountain View CA Chung Chun Wei - Foster City CA
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
Geometrically Restricted 2-Indolinone Derivatives As Modulators Of Protein Kinase Activity
Peng Cho Tang - Moraga CA Todd Anthony Miller - Union City CA Li Sun - Foster City CA Ngoc My Tran - Redwood City CA Asaad Nematalla - Walnut Creek CA Anh Thi Nguyen - Fremont CA
Assignee:
Sugen, Inc. - South San Francisco CA
International Classification:
C07D20934
US Classification:
514323, 514414, 514418, 546201, 548455, 548486
Abstract:
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
3-Methylidenyl-2-Indolinone Modulators Of Protein Kinase
Pen Cho Tang - Moraga CA Li Sun - Foster City CA Todd Anthony Miller - Bend OR Congxin Liang - Sunnyvale CA Ngoc My Tran - Redwood City CA Anh Thi Nguyen - Fremont CA Asaad Nematalla - Walnut Creek CA
Assignee:
Sugen, Inc. - South San Francisco CA
International Classification:
A61K 314015
US Classification:
514414, 514418, 548455, 548468, 548486
Abstract:
The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Pyrrole Substituted 2-Indolinone Protein Kinase Inhibitors
Peng Cho Tang - Moraga CA Todd A. Miller - Bend OR Xiaoyuan Li - Los Altos CA Li Sun - Foster City CA Chung Chen Wei - Foster City CA Shahrzad Shirazian - Corte Madera CA Congxin Liang - Sunnyvale CA Tomas Vojkovsky - San Francisco CA Asaad S. Nematalla - Concord CA Michael Hawley - Kalamazoo MI
Assignee:
Sugen, Inc. - South San Francisco CA Pharmacia Upjohn Co. - Kalamazoo MI
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Geometrically Restricted 2-Indolinone Derivatives As Modulators Of Protein Kinase Activity
Peng Cho Tang - Moraga CA Todd Anthony Miller - Union City CA Li Sun - Foster City CA Ngoc My Tran - Redwood City CA Asaad Nematalla - Walnut Creek CA Anh Thi Nguyen - Fremont CA
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Peng Cho Tang - Moraga CA Li Sun - Foster City CA Gerald McMahon - San Francisco CA Todd Anthony Miller - Bend OR Shahrzad Shirazian - Corte Madera CA Chung Chen Wei - Foster City CA Xiaoyuan Li - Los Altos CA Congxin Liang - Sunnyvale CA
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
3-Methylidenyl-2-Indolinone Modulators Of Protein Kinase
Pen Cho Tang - Moraga CA, US Li Sun - Foster City CA, US Todd Anthony Miller - Bend OR, US Congxin Liang - Sunnyvale CA, US Ngoc My Tran - Redwood City CA, US Anh Thi Nguyen - Fremont CA, US Asaad Nematalla - Walnut Creek CA, US
The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Pyrrole Substituted 2-Indolinone Protein Kinase Inhibitors
Peng Cho Tang - Moraga CA, US Todd A. Miller - Bend OR, US Xiaoyuan Li - Los Altos CA, US Li Sun - Foster City CA, US Chung Chen Wei - Foster City CA, US Shahrzad Shirazian - Corte Madera CA, US Congxin Liang - Sunnyvale CA, US Tomas Vojkovsky - San Francisco CA, US Asaad S. Nematalla - Concord CA, US Michael Hawley - Kalamazoo MI, US
Assignee:
Agouron Pharmaceuticals, Inc. - San Diego CA
International Classification:
A61K 31/404 C07D 403/06
US Classification:
514414, 548468
Abstract:
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
LHOIST NORTH AMERICA (CHEMICAL LIME COMPANY / FRANKLIN INDUSTRIAL MINERALS / IMV MINERALS)
Oct 2006 to 2000 Sales ManagerU.S. FILTER Oakland, CA Feb 2006 to Oct 2006 Account ManagerCHEMICAL LIME COMPANY (LHOIST NORTH AMERICA) New Braunfels, TX Sep 2003 to Nov 2005 Account ManagerVULCAN MATERIALS COMPANY San Antonio, TX Sep 2002 to Sep 2003 Plant Supervisor / Assistant Plant ManagerVULCAN MATERIALS COMPANY Brownwood, TX Sep 2001 to Sep 2002 Plant SupervisorVULCAN MATERIALS COMPANY Uvalde, TX Apr 2000 to Sep 2001 Operations Manager TraineeLAW ENGINEERING & ENVIRONMENTAL SERVICES, INC Birmingham, AL 1998 to 2000 Staff Geologist
Education:
University of Alabama Tuscaloosa, AL 1998 Bachelor of Science in Geology
We need to be loud and clear that swimming in coastal waters is currently a threat to public health, safety and welfare, said a statement issued by Todd Miller, executive director of the nonprofit federation.
Date: Sep 27, 2018
Category: Headlines
Source: Google
Hell and high water: Florence turned familiar haunts into an alien expanse
A few years ago, I was out on a boat on Bogue Sound with a person who knows as much about the coast as anyone. Todd Miller is the founder and executive director of the North Carolina Coastal Federation, which works to maintain the health of the states 12,000 miles of estuarian shoreline. Millers tned a little boy on Sunday night made their way through South Carolina on Wednesday, as the Pee Dee crested and shut down Interstate 95, perhaps the most important highway in the US. The same water that killed farm animals inland changed the complexion of Bogue Sound in front of Todd Millers house. The s
Date: Sep 21, 2018
Category: Headlines
Source: Google
Silverado, PGA Tour get a little payback from stars
onday's sectional at Lake Merced and Olympic include longtime tour pros Kevin Sutherland, Alex Cejka and Jeff Brehaut; Pebble Beach caddie Casey Boyns, a former California Amateur champion; local college standouts Brandon Hagy, Joel Stalter, Maverick McNealy, Cory McElyea and Cody Blick; and Todd Miller
Date: May 28, 2014
Category: Sports
Source: Google
Victim of ex-Gophers QB Nelson 'fighting for his life'
We know that there was at least one more person involved in this assault, Todd Miller, director of public safety for the city of Mankato, said at a news conference Monday. We have video of that individual, as well as video of a number of other persons that we are attempting to locate.
Date: May 12, 2014
Category: Sports
Source: Google
Ex-Gopher Philip Nelson released on $20K bail; 2nd attacker sought
The entire thing lasted five to 10 seconds, said Todd Miller, Mankatos public safety director. Mr. Nelson and Mr. Kolstad know each other and played football against each other in Mankato in high school.
Date: May 12, 2014
Category: Sports
Source: Google
Sundance: Lionsgate, CNN Films Team for Doc 'Dinosaur 13'
Director and producer Todd Miller has been a filmmaker for more than a decade, but he made his debut at Sundance with Dinosaur 13, which premiered at Eccles Theatre on Jan. 16. in the U.S. Documentary Category.
Date: Jan 17, 2014
Source: Google
Sundance Film Festival unwraps a fierce 2014 competition slate
"Dinosaur 13" (Director: Todd Miller) This documentary details the 1990 discovery of "Sue," one of the largest Tyrannosaurus rex specimens ever found, and the tangled legal battle over the fossils ownership that followed. This is one of the four "Day One" movies premiering on Jan. 16.
Mississippi Highway Patrol Cpl. Todd Miller said the motorhome blew a front tire, ran off Interstate 59 in Forrest County, Miss., and hit a tree in the median. He said two people were ejected from the motorhome. Benedict said he's not sure if Parker was one of them.
Date: Jan 08, 2012
Category: U.S.
Source: Google
Googleplus
Todd Miller
Lived:
Scottsdale, AZ Cambridge, MA San Mateo, CA
Flickr
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"Josie" Todd Miller, John Thomakos, Eric Scott
Todd Miller guitar, Eric Scott bass, John Thomakos drums. These guys a...
Category:
Music
Uploaded:
30 Jul, 2009
Duration:
8m 19s
Peter Frampton's "Do You Feel" by TODD MILLER...
www.myspace.com www.myspace.com TODD MILLER, ERIC SCOTT, JOHN DAVIS at...
Category:
Music
Uploaded:
05 Mar, 2009
Duration:
4m 53s
Todd Miller "Keep Forgetting" w/a twist. John...
Jan 6 2010 at the Cats Eye in Fells point. Todd Miller, guitar, Eric S...
Category:
Music
Uploaded:
07 Jan, 2010
Duration:
7m 22s
Todd Miller on Broadway
Lake braddock Secondary School, Burke Virginia Dessert...on broadway M...
Category:
Music
Uploaded:
08 Mar, 2008
Duration:
4m 41s
"I Keep Forgetting" TODD MILLER does Michael ...
TODD MILLER, ERIC SCOTT, JOHN THOMAKOS do Michael McDonald's "I Keep F...
Category:
Music
Uploaded:
18 Dec, 2008
Duration:
3m 41s
Todd Miller - head athletic trainer, Ohio Wes...
Miller is a certified member of NATA and a licensed athletic trainer b...