Tokiko Watanabe

US Patent:

20110236417, Sep 29, 2011

Filed:

Mar 23, 2011

Appl. No.:

13/070110

Inventors:

Shinji Watanabe - Madison WI, US
Tokiko Watanabe - Madison WI, US
Yoshihiro Kawaoka - Middleton WI, US

Assignee:

WARF - Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A61K 39/145
A61P 31/16
A61P 37/04

US Classification:

4241991

Abstract:

The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant M gene expresses a functional M1 protein and a mutant M2 protein with a deletion of the cytoplasmic tail and either lacking a transmembrane domain or having a mutated transmembrane domain.

US Patent:

20090074812, Mar 19, 2009

Filed:

Jun 18, 2008

Appl. No.:

12/214414

Inventors:

Tokiko Watanabe - Madison WI, US
Yoshihiro Kawaoka - Middleton WI, US

Assignee:

Wisconsin Alumni Research Foundation - madison WI

International Classification:

A61K 39/285
C12N 7/01

US Classification:

4242021, 4242091, 4352351

Abstract:

A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is attenuated in vivo, is provided, as well the resulting virus and vaccines with the virus.