Tom C Tsang

US Patent:

7098191, Aug 29, 2006

Filed:

Mar 29, 2002

Appl. No.:

10/108486

Inventors:

Tom Tsang - Tuscon AZ, US
Eugene W. Gerner - Tucson AZ, US
David T. Harris - Tucson AZ, US
Evan Hersh - Tucson AZ, US

Assignee:

The Arizona Board of Reagents - Tucson AZ

International Classification:

A61K 48/00
C12N 1/21
C12N 5/10
C12N 15/67
C12N 15/79

US Classification:

514 44, 424 932, 424 9321, 4353201, 435 691, 435455, 435456, 435458, 4352523

Abstract:

Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other genes of interest in mammalian cells are provided, as well as methods of using the same.

US Patent:

7285542, Oct 23, 2007

Filed:

Dec 12, 2003

Appl. No.:

10/733280

Inventors:

Tom Tsang - Tucson AZ, US
Eugene W. Gerner - Tucson AZ, US
David T. Harris - Tucson AZ, US
Evan Hersh - Tucson AZ, US

Assignee:

The Arizona Board of Regents on behalf of The University of Arizona - Tucson AZ

International Classification:

A61K 48/00
C12N 15/85
C12N 15/86

US Classification:

514 44, 424 932, 4353201, 435455, 435456, 435458

Abstract:

Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.

US Patent:

8158126, Apr 17, 2012

Filed:

Aug 25, 2006

Appl. No.:

12/064745

Inventors:

David T. Harris - Tucson AZ, US
Tom C. Tsang - Tucson AZ, US
Xianghui He - Tianjin, CN
Brian L. Pipes - Tucson AZ, US
Linda C. Meade-Tollin - Tucson AZ, US

Assignee:

Arizona Board of Regents on Behalf of The University of Arizona - Tucson AZ

International Classification:

A61K 39/395
C07K 16/28

US Classification:

4241411, 4241301, 5303881

Abstract:

Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell (FIG. ). Antibodies against ubiquitin are shown to inhibit tumor cell migration.

US Patent:

20120201808, Aug 9, 2012

Filed:

Apr 16, 2012

Appl. No.:

13/448112

Inventors:

David T. Harris - Tucson AZ, US
Tom C. Tsang - Tucson AZ, US
Xianghui He - Tianjin, CN
Brian L. Pipes - Tucson AZ, US
Linda C. Meade-Tollin - Tucson AZ, US

International Classification:

A61K 39/395
C12N 5/09
A61P 35/04

US Classification:

4241301, 435375

Abstract:

Methods for modeling cancer cell migration, screening drugs for effects on tumor cell migration, and detecting the potential for tumor cell migration relating to the fusion of a bone marrow derived stem cell with a genetically altered cell. Antibodies against ubiquitin are shown to inhibit tumor cell migration.

US Patent:

20120295344, Nov 22, 2012

Filed:

Apr 16, 2012

Appl. No.:

13/448251

Inventors:

David T. Harris - Tucson AZ, US
Tom C. Tsang - Tucson AZ, US
Xianghui He - Tianjin, CN
Brian L. Pipes - Tucson AZ, US
Michael E. Pennington - Tucson AZ, US
Linda C. Meade-Tollin - Tucson AZ, US

Assignee:

Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ

International Classification:

C12N 5/16

US Classification:

435346

Abstract:

Model systems and methods for exploring mechanisms of carcinogenesis and the acquisition of metastatic ability, and to provide insights into potential therapeutic targets. The systems include and methods involve fusion of a stem cell and a genetically altered cell to evaluate carcinogenesis and metastasis and for the discovery and evaluation of new therapeutic targets to inhibit metastasis and other markers of carcinogenesis.

US Patent:

6709858, Mar 23, 2004

Filed:

Nov 3, 1998

Appl. No.:

09/185243

Inventors:

Tom Tsang - Tucson AZ
Eugene W. Gerner - Tucson AZ
David T. Harris - Tucson AZ
Evan Hersh - Tucson AZ

Assignee:

The Arizona Board of Regents on behalf of The University of Arizona - Tucson AZ

International Classification:

C12N 1585

US Classification:

4353201, 435 691, 435455, 435456, 435458, 424 932, 514 44

Abstract:

Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.

US Patent:

20180117249, May 3, 2018

Filed:

Nov 29, 2017

Appl. No.:

15/825613

Inventors:

- Tucson AZ, US
Linda Meade-Tollin - Tucson AZ, US
Tom C. Tsang - Tucson AZ, US

Assignee:

Cure Cancer Worldwide LLC - Tucson AZ

International Classification:

A61M 5/172
A61B 5/145
A61B 5/0402
A61B 5/00
A61K 38/28
A61K 31/7004
A61K 45/06
A61P 31/00
A61P 35/04
A61P 3/10
A61P 3/08
A61K 9/00
A61M 5/14
A61M 5/168
A61M 5/142

Abstract:

A system for chemotherapy delivery comprises a plurality of slots to receive a corresponding one of a plurality of cartridges; a plurality of pumps, wherein each of the plurality of pumps is configured to be connected to the corresponding one of the plurality of cartridges, and the plurality of pumps are configured to pump at least one drug contained in at least one of the plurality of cartridges to a patient according to a treatment protocol; a blood glucose sensor communicatively coupled to the plurality of pumps, and configured to measure a blood glucose level of the patient; a processor connected to the plurality of pumps and the blood glucose sensor and configured to adjust a delivery property of the at least one drug according to the measured blood glucose level of the patient.

US Patent:

20140308297, Oct 16, 2014

Filed:

Jun 25, 2014

Appl. No.:

14/315039

Inventors:

David T. Harris - Tucson AZ, US
Tom C. Tsang - Tucson AZ, US
Xianghui He - Tianjin, CN
Brian L. Pipes - Tucson AZ, US
Michael E. Pennington - Tucson AZ, US
Linda C. Meade-Tollin - Tucson AZ, US

Assignee:

Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ

International Classification:

C07K 16/28

US Classification:

4241721, 435325

Abstract:

Model systems and methods for exploring mechanisms of carcinogenesis and the acquisition of metastatic ability, and to provide insights into potential therapeutic targets. The systems include and methods involve fusion of a stem cell and a genetically altered cell to evaluate carcinogenesis and metastasis and for the discovery and evaluation of new therapeutic targets to inhibit metastasis and other markers of carcinogenesis.