Manmohan Singh - Lexington MA, US David A.G. Skibinski - Singapore, SG Tom Yao-Hsiang Wu - San Diego CA, US Yongkai Li - San Diego CA, US Alex Cortez - San Diego CA, US Xiaoyue Zhang - San Diego CA, US Yefen Zou - San Diego CA, US Timothy Z. Hoffman - San Diego CA, US Jianfeng Pan - San Diego CA, US Kathy Yue - Minneapolis MN, US
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.