Trevor K Mischki

US Patent:

20040122014, Jun 24, 2004

Filed:

Oct 29, 2003

Appl. No.:

10/696464

Inventors:

Mathai Mammen - Redwood Shores CA, US
Richard Wilson - El Sobrante CA, US
Yan Chen - Burlingame CA, US
Sarah Dunham - San Rafael CA, US
Adam Hughes - San Francisco CA, US
Craig Husfeld - Redwood City CA, US
Yu-Hua Ji - Redwood City CA, US
Li Li - Sunnyvale CA, US
Trevor Mischki - Burlingame CA, US
Ioanna Stergiades - San Francisco CA, US

International Classification:

A61K031/513
A61K031/497
A61K031/501
C 07D 4 3/14

US Classification:

514/252030, 514/255050, 514/256000, 514/318000, 544/238000, 544/405000, 544/317000, 546/192000

Abstract:

This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.