Tuan Vo-Dinh

US Patent:

6422998, Jul 23, 2002

Filed:

Sep 20, 1999

Appl. No.:

09/398703

Inventors:

Tuan Vo-Dinh - Knoxville TN
Ajit Sadana - Oxford MS

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

A61B 500

US Classification:

600300

Abstract:

Characteristics of time varying data, such as an electrical signal, are analyzed by converting the data from a temporal domain into a spatial domain pattern. Fractal analysis is performed on the spatial domain pattern, thereby producing a fractal dimension D. The fractal dimension indicates the regularity of the time varying data.

US Patent:

6448064, Sep 10, 2002

Filed:

Jan 29, 2001

Appl. No.:

09/771530

Inventors:

Tuan Vo-Dinh - Knoxville TN
Alan Wintenberg - Knoxville TN
Milton N. Ericson - Knoxville TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

C12M 134

US Classification:

4352872, 435 6, 435 911, 435 912, 435183, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433

Abstract:

The present invention discloses a self-contained miniature DNA biosensor designed to detect specific molecular targets, particularly suitable for detection of nucleic acids. For example, hybridized DNA may be detected without external monitoring or signal transmission. The miniaturized biosensor is a biochip comprising multiple biological sensing elements such as DNA probes, excitation microlasers, a sampling waveguide equipped with optical detectors (fluorescence and Raman), integrated electro-optics, and a biotelemetric radio frequency signal generator. The novel integrated circuit biochip microsystem (ICBM) is suitable for gene analysis and will allow rapid, large-scale, and cost-effective production of gene biochips.

US Patent:

6583397, Jun 24, 2003

Filed:

Jul 19, 2001

Appl. No.:

09/909267

Inventors:

Tuan Vo-Dinh - Knoxville TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G02B 2740

US Classification:

2502015, 250235, 2502081, 356457

Abstract:

Surface-enhanced Raman optical data storage (SERODS) systems having increased reading and writing speeds, that is, increased data transfer rates, are disclosed. In the various SERODS read and write systems, the surface-enhanced Raman scattering (SERS) data is written and read using a two-dimensional process called parallel signal transfer (PST). The various embodiments utilize laser light beam excitation of the SERODS medium, optical filtering, beam imaging, and two-dimensional light detection. Two- and three-dimensional SERODS media are utilized. The SERODS write systems employ either a different laser or a different level of laser power.

US Patent:

6614730, Sep 2, 2003

Filed:

Jul 19, 2001

Appl. No.:

09/909236

Inventors:

Tuan Vo-Dinh - Knoxville TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G11B 1100

US Classification:

369 1301, 369 1356, 369126

Abstract:

Surface-enhanced Raman optical data storage (SERODS) systems having increased reading and writing speeds, that is, increased data transfer rates, are disclosed. In the various SERODS read and write systems, the surface-enhanced Raman scattering (SERS) data is written and read using a two-dimensional process called parallel signal transfer (PST). The various embodiments utilize laser light beam excitation of the SERODS medium, optical filtering, beam imaging, and two-dimensional light detection. Two- and three-dimensional SERODS media are utilized. The SERODS write systems employ either a different laser or a different level of laser power.

US Patent:

6743581, Jun 1, 2004

Filed:

Apr 29, 2002

Appl. No.:

09/890047

Inventors:

Tuan Vo-Dinh - Knoxville TN

Assignee:

UT-Battelle, LC - Oak Ridge TN

International Classification:

C12Q 168

US Classification:

435 6, 435 71, 435174, 4352831, 4352872, 4352887, 4353201, 435325, 422 681, 422 8205, 422 8201, 356335, 356346, 536 231, 536 243, 530300, 530350

Abstract:

An integrated biosensor system for the simultaneously detection of a plurality of different types of targets includes at least one sampling platform, the sampling platform including a plurality of receptors for binding to the targets. The plurality of receptors include at least one protein receptor and at least one nucleic acid receptor. At least one excitation source of electromagnetic radiation at a first frequency is provided for irradiating the receptors, wherein electromagnetic radiation at a second frequency different from the first frequency is emitted in response to irradiating when at least one of the different types of targets are bound to the receptor probes. An integrated circuit detector system having a plurality of detection channels is also provided for detecting electromagnetic radiation at said second frequency, the detection channels each including at least one detector.

US Patent:

6744503, Jun 1, 2004

Filed:

Dec 20, 2001

Appl. No.:

10/022239

Inventors:

Tuan Vo-Dinh - Knoxville TN
Mohammad R. Hajaligol - Midlothian VA

Assignee:

Philip Morris Incorporated - New York NY

International Classification:

G01J 330

US Classification:

356318, 356317, 2504581, 2504591

Abstract:

An apparatus for monitoring vapor phase polycyclic aromatic hydrocarbons in a high-temperature environment has an excitation source producing electromagnetic radiation, an optical path having an optical probe optically communicating the electromagnetic radiation received at a proximal end to a distal end, a spectrometer or polychromator, a detector, and a positioner coupled to the first optical path. The positioner can slidably move the distal end of the optical probe to maintain the distal end position with respect to an area of a material undergoing combustion. The emitted wavelength can be directed to a detector in a single optical probe 180Â backscattered configuration, in a dual optical probe 180Â backscattered configuration or in a dual optical probe 90Â side scattered configuration. The apparatus can be used to monitor an emitted wavelength of energy from a polycyclic aromatic hydrocarbon as it fluoresces in a high temperature environment.

US Patent:

6965431, Nov 15, 2005

Filed:

Feb 28, 2003

Appl. No.:

10/376965

Inventors:

Tuan Vo-Dinh - Knoxville TN, US
Alan Wintenberg - Knoxville TN, US

Assignee:

Ut-Battelle, LLC - Oak Ridge TN

International Classification:

G01V003/44

US Classification:

356301

Abstract:

A scanning tunable detection system and related method for analyzing samples includes a source of time varying excitation signals and a tunable optical filter for selectively transmitting time-varying optical signals emanated from a sample following irradiation with the time varying excitation signals. A detector is provided for converting the time-varying optical signals to electrical detection signals. The system can identify components in a sample using phase sensitive or time sensitive detection. A slew scan mode can be used to permit slow scanning through spectral regions rich in information but quickly in regions without such information.

US Patent:

7103402, Sep 5, 2006

Filed:

Oct 2, 2003

Appl. No.:

10/677703

Inventors:

Tuan Vo-Dinh - Knoxville TN, US

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

A61B 5/00

US Classification:

600476, 600473, 600478, 606 15, 356301

Abstract:

A diagnostic method and associated system includes the steps of exposing at least one sample location with excitation radiation through a single optical waveguide or a single optical waveguide bundle, wherein the sample emits emission radiation in response to the excitation radiation. The same single optical waveguide or the single optical waveguide bundle receives at least a portion of the emission radiation from the sample, thus providing co-registration of the excitation radiation and the emission radiation. The wavelength of the excitation radiation and emission radiation is synchronously scanned to produce a spectrum upon which an image can be formed. An increased emission signal is generated by the enhanced overlap of the excitation and emission focal volumes provided by co-registration of the excitation and emission signals thus increasing the sensitivity as well as decreasing the exposure time necessary to obtain an image.