Tyler M Dylan

US Patent:

20050281999, Dec 22, 2005

Filed:

Feb 17, 2005

Appl. No.:

11/061301

Inventors:

Ray Hofmann - Capistrano Beach CA, US
Bruce Ackert - Henderson NV, US
Craig Collins - San Diego CA, US
Randy Meirowitz - San Diego CA, US
Tyler Dylan - San Diego CA, US

International Classification:

B32B003/26
B32B027/00
B32B009/00

US Classification:

428304400, 428318400, 428319300, 428312200, 264046400, 264271100

Abstract:

In accordance with the present invention, structural and other composite materials have been developed which have superior performance properties, including high compressive strength, high tensile strength, high shear strength, and high strength-to-weight ratio, and methods for preparing same. Invention materials have the added benefits of ease of manufacture, and are inexpensive to manufacture. The superior performance properties of invention materials render such materials suitable for a wide variety of end uses. For example, a variety of substances can be applied to invention materials without melting, dissolving or degrading the basic structure thereof. This facilitates bonding invention materials to virtually any surface or substrate. Moreover, the bond between invention materials and a variety of substrates is exceptionally strong, rendering the resulting bonded article suitable for use in a variety of demanding applications. Invention materials can be manufactured in a wide variety of sizes, shapes, densities, in multiple layers, and the like; and the performance properties thereof can be evaluated in a variety of ways.

US Patent:

20060104968, May 18, 2006

Filed:

Sep 27, 2005

Appl. No.:

11/238171

Inventors:

Louis Bookbinder - San Diego CA, US
Anirban Kundu - San Diego CA, US
Gregory Frost - Del Mar CA, US
Michael Haller - San Diego CA, US
Gilbert Keller - Belmont CA, US
Tyler Dylan - San Diego CA, US

Assignee:

Halozyme, Inc. - San Diego CA

International Classification:

A61K 38/47
C12N 9/24

US Classification:

424094610, 435200000

Abstract:

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

US Patent:

20090123367, May 14, 2009

Filed:

Feb 23, 2006

Appl. No.:

11/884862

Inventors:

Louis H. Bookbinder - San Diego CA, US
Anirban Kundu - San Diego CA, US
Gregory I. Frost - Del Mar CA, US
Michael F. Haller - San Diego CA, US
Gilbert A. Keller - Belmont CA, US
Tyler M. Dylan - San Diego CA, US

Assignee:

DELFMEMS - Villeneuve d' Ascq

International Classification:

A61K 51/10
C12N 9/26
A61K 38/47
A61K 49/00
A61K 39/395
A61K 38/21
A61K 39/09
A61P 35/00
A61K 39/25
A61K 39/165
A61K 38/20
A61K 39/13
A61K 39/145
A61K 39/29

US Classification:

424 149, 435201, 424 9462, 424 91, 4241421, 424 852, 4241341, 4242171, 4241731, 4241331, 4242061, 4242261, 4242271, 424 857, 424 856, 424 855, 4242121, 4242441, 4242301, 4241741

Abstract:

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

US Patent:

20050260186, Nov 24, 2005

Filed:

Feb 23, 2005

Appl. No.:

11/065716

Inventors:

Louis Bookbinder - San Diego CA, US
Anirban Kundu - San Diego CA, US
Gregory Frost - Del Mar CA, US
Michael Haller - San Diego CA, US
Gilbert Keller - Belmont CA, US
Tyler Dylan - San Diego CA, US

Assignee:

Halozyme, Inc. - San Diego CA

International Classification:

C07H021/04
C12P021/06
A61K038/47
C12N009/24

US Classification:

424094610, 435200000, 435069100, 435320100, 435325000, 536023200

Abstract:

The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.