Tyler O Smith

US Patent:

20210389245, Dec 16, 2021

Filed:

Oct 4, 2019

Appl. No.:

17/282807

Inventors:

- Natick MA, US
Alan Lloyd Weeks - S. Easton MA, US
Valerie Villareal - Boston MA, US
Patrick Murphy - Allston MA, US
Eric Anthony Robertson - San Antonio TX, US
Deirdre Ellen Day - Winchester MA, US
Matthew Bernard Dean - Far Hills NJ, US
Todd Glendon Campbell - Holliston MA, US
Brian Christopher Burke - Mahwah NJ, US
Tyler S. Smith - Cambridge MA, US
Thomas Christopher Hartner - Pepperell MA, US
Stanley Owen Thompson - New Boston NH, US
Nhat Nam Trinh - Quincy MA, US
David Carpenter - Jaffrey NH, US
Gregory J. Kintz - Santa Cruz CA, US
Paul Koh - New York NY, US
David Jennings Dostal - Hanover NH, US
Kevin Doherty - Palo Alto CA, US
Joel F. Jensen - Redwood City CA, US
William Law - Palo Alto CA, US
J. Efraín Alcorta - Austin TX, US

International Classification:

G01N 21/64
B01L 3/00

Abstract:

The present disclosure is drawn to devices and systems for target detection in samples, particularly allergen detection in food samples. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. The allergen detection utilizes nucleic acid molecules as detection agents and detection probes.

US Patent:

20200046184, Feb 13, 2020

Filed:

Aug 9, 2019

Appl. No.:

16/536901

Inventors:

- Needham MA, US
Tyler S. SMITH - Boston MA, US
Wenxiu GAO - Suzhou, CN
Ian LIU - Suzhou, CN
Nicholas SARDAR - London, GB

International Classification:

A47L 9/00
A47L 9/04
A47L 9/06

Abstract:

A cleaning apparatus may include at least one isolator configured to absorb mechanical vibration generated by contact between an agitator and a combining unit to reduce noise and/or vibration. The isolator may include at least one combing isolator disposed at least partially between the combing unit and the surface cleaning head. Alternatively (or in addition), the isolator may include a panel isolator disposed at least partially between a housing of the cleaning apparatus and a panel.

US Patent:

20190191947, Jun 27, 2019

Filed:

Dec 21, 2018

Appl. No.:

16/229363

Inventors:

- Needham MA, US
Nicholas SARDAR - London, GB
Tyler S. SMITH - Boston MA, US

International Classification:

A47L 9/04

Abstract:

A cleaning apparatus comprising a housing, at least one agitator configured to be rotatably coupled to the housing, a combing unit comprising a plurality of spaced teeth configured to contact the agitator for preventing build up and removing debris, and a switch configured to cause the combing unit to move between an active mode in which the plurality of spaced teeth are configured to contact the agitator for preventing build up and removing debris, and an inactive mode in which the plurality of spaced teeth are configured to not contact the agitator. The switch may be configured to cause the combing unit to rotate about a pivot axis between the active mode and the inactive mode. The switch may be configured to convert linear motion of the switch into the rotational motion of the combing unit about the pivot axis.

US Patent:

20180346457, Dec 6, 2018

Filed:

Apr 27, 2018

Appl. No.:

15/965506

Inventors:

- Palo Alto CA, US
Ryan HENNING - Palo Alto CA, US
Alan JI - Palo Alto CA, US
Tyler Smith - Palo Alto CA, US
Bradley HELLER - Palo Alto CA, US
Thumkunta Jagadeeswar REDDY - Palo Alto CA, US
Sylvain ROCHELEAU - Palo Alto CA, US
Marc Andre BEAULIEU - Palo Alto CA, US

International Classification:

C07D 413/14
C07D 417/14
A61P 35/00

Abstract:

The present disclosure provides, inter alia, RAF-Degrading Conjugate Compounds that are useful in the treatment of cancer and other RAF related diseases. Also provided are, pharmaceutical compositions, methods of treatment, and kits comprising a RAF-Degrading Conjugate Compound.

US Patent:

20180255991, Sep 13, 2018

Filed:

Mar 10, 2018

Appl. No.:

15/917598

Inventors:

- Needham MA, US
John FREESE - Needham MA, US
Gordon HOWES - Suzhou, CN
Nancy GAO WENXIU - Suzhou, CN
David S. CLARE - London, GB
Nathan HERRMANN - Boston MA, US
Hugh Jamie CROGGON - London, GB
Nicholas SARDAR - London, GB
Tyler SMITH - Brighton MA, US
Ian LIU - Suzhou, CN

International Classification:

A47L 9/04
A47L 11/24
A47L 11/40

Abstract:

A surface cleaning apparatus including a body defining an agitation chamber, an agitator partially disposed within the agitation chamber and configured to rotate about a pivot axis, and a debrider at least partially disposed within the agitation chamber. The agitator includes an elongated body having a first and a second end, a sidewall extending radially outward from the elongated body extending between the first and the second ends, and a plurality of bristles extending radially outward from the elongated body. The plurality of bristles are arranged in at least one row adjacent to the sidewall. The debrider includes a plurality of teeth configured to contact a portion of the sidewall as the agitator rotates about the pivot axis.

US Patent:

20170172845, Jun 22, 2017

Filed:

Nov 24, 2014

Appl. No.:

15/039043

Inventors:

- EINDHOVEN, NL
VIRGINIA HIGLEY - TYNGSBORO MA, US
TYLER DOUGLAS SMITH - CORVALLIS OR, US
STEVEN JOSEPH FRANKOVICH - MCMINNVILLE OR, US
DANIEL CALVERT CANFIELD - MCMINNVILLE OR, US

International Classification:

A61H 31/00

Abstract:

A cardio-pulmonary compression device includes a motor () having a rotating portion, and a ball nut () mounted on the rotating portion and configured to rotate with the rotating portion. A ball screw () is received in the ball nut such that rotation on the ball nut advances and/or retracts the ball screw in accordance with a direction of the motor. A pad assembly () is coupled to an end portion of the ball screw such that longitudinal motion of the ball screw imparts a compression cycle to a patient.