Vaibhav A Narayan

US Patent:

20060029987, Feb 9, 2006

Filed:

Aug 6, 2004

Appl. No.:

10/912580

Inventors:

Bruno Domon - Rockville MD, US
Ian McCaffery - Rockville MD, US
Vaibhav Narayan - Gaithersburg MD, US
Scott Patterson - Newbury Park CA, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

G01N 33/574

US Classification:

435007230

Abstract:

Methods and compositions for diagnosing, detecting a pancreatic disease associated with differential expression of PCATs (e.g., CD49b, CD51, CD71 and E-Cadherin) in comparison to healthy cells.

US Patent:

20060029988, Feb 9, 2006

Filed:

Aug 6, 2004

Appl. No.:

10/912582

Inventors:

Bruno Domon - Rockville MD, US
Ian McCaffery - Rockville MD, US
Vaibhav Narayan - Gaithersburg MD, US
Scott Patterson - Newbury Park CA, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

G01N 33/574

US Classification:

435007230

Abstract:

Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of E-cadherin in comparison to healthy cells. Also provided are antagonists or agonists of E-cadherin, and methods for screening agents that modulate the E-cadherin level or activity in vivo or in vitro.

US Patent:

20060035239, Feb 16, 2006

Filed:

Aug 6, 2004

Appl. No.:

10/912581

Inventors:

Bruno Domon - Rockville MD, US
Ian McCaffery - Rockville MD, US
Vaibhav Narayan - Gaithersburg MD, US
Scott Patterson - Newbury Park CA, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C12Q 1/68
G01N 33/574

US Classification:

435006000, 435007230

Abstract:

Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of CD51 in comparison to healthy cells. Also provided are antagonists or agonists of CD51, and methods for screening agents that modulate the CD51 level or activity in vivo or in vitro.

US Patent:

20060039907, Feb 23, 2006

Filed:

Aug 6, 2004

Appl. No.:

10/912585

Inventors:

Bruno Domon - Rockville MD, US
Ian McCaffery - Rockville MD, US
Vaibhav Narayan - Gaithersburg MD, US
Scott Patterson - Newbury Park CA, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C12Q 1/68
G01N 33/574
A61K 39/395

US Classification:

424143100, 435007230, 435006000

Abstract:

Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of CD71 in comparison to healthy cells. Also provided are antagonists or agonists of CD71, and methods for screening agents that modulate the CD71 level or activity in vivo or in vitro.

US Patent:

20060294607, Dec 28, 2006

Filed:

Mar 29, 2006

Appl. No.:

11/391386

Inventors:

William Fitzhugh - Darnestown MD, US
Steve Ruben - Brookville MD, US
Vaibhav Narayan - Carmel IN, US
Charles Birse - North Potomac MD, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

A01K 67/027
C12Q 1/68
G01N 33/53
C07H 21/04
C12P 21/06
C07K 14/705

US Classification:

800014000, 435006000, 435007100, 435069100, 435320100, 435325000, 530350000, 514012000, 536023500

Abstract:

The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents that modulate podocalyxin activities. Further the present invention provides methods for treating diseases associated with podocalyxin expression.

US Patent:

20070059757, Mar 15, 2007

Filed:

Nov 13, 2006

Appl. No.:

11/598170

Inventors:

Bruno Domon - Rockville MD, US
Ian McCaffery - Rockville MD, US
Vaibhav Narayan - Gaithersburg MD, US
Scott Patterson - Newbury Park CA, US

International Classification:

C12Q 1/68
G01N 33/574

US Classification:

435006000, 435007230

Abstract:

Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of E-cadherin in comparison to healthy cells. Also provided are antagonists or agonists of E-cadherin, and methods for screening agents that modulate the E-cadherin level or activity in vivo or in vitro.

US Patent:

20090123461, May 14, 2009

Filed:

Oct 21, 2008

Appl. No.:

12/255340

Inventors:

William Fitzhugh - Darnestown MD, US
Steve Ruben - Brookville MD, US
Vaibhav Narayan - Carmel IN, US
Charles E. Birse - North Potomac, MD, US

Assignee:

Celera Corporation - Alameda CA

International Classification:

A61K 39/395
C07K 14/00
C07K 16/00
C07H 21/00
A01K 67/027
C12N 15/63
A61P 35/00
C12N 5/10
C12P 21/00
C12Q 1/68
G01N 33/53

US Classification:

4241301, 530350, 5303879, 536 231, 800 13, 4353201, 435325, 435 691, 435 6, 435 71

Abstract:

The present invention provides a method for diagnosing and detecting cancer. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in cancer (podocalyxin) and antibodies that bind podocalyxins. The present invention provides that podocalyxins are used as targets for screening agents that modulate podocalyxin activities. Further the present invention provides methods for treating diseases associated with podocalyxin expression.

US Patent:

20090138977, May 28, 2009

Filed:

Oct 3, 2008

Appl. No.:

12/287040

Inventors:

Bruno Domon - Rockville MD, US
Ian McCaffery - Rockville MD, US
Vaibhav Narayan - Rockville MD, US
Scott Patterson - Newbury Park CA, US

Assignee:

CELERA CORPORATION - Alameda CA

International Classification:

A01K 67/027
C07K 14/00
A61K 38/16
C07H 21/00
C07H 21/02
C12N 5/06
A61P 35/00
G01N 33/53
A61K 39/395
C07K 16/18
C12N 5/16
C12N 7/01

US Classification:

800 13, 530350, 514 12, 536 231, 536 245, 5303871, 435326, 4352351, 5303873, 4241331, 435375, 436501

Abstract:

The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAT) and antibodies binds to PCAT. The present invention provides that PCAT is used as targets for screening agents that modulates the PCAT activities. Further, the present invention provides methods for treating diseases associated with pancreas.