Van Thi Hoang

US Patent:

20160221975, Aug 4, 2016

Filed:

Sep 11, 2014

Appl. No.:

15/021592

Inventors:

- New Orleans LA, US
- Pittsburgh PA, US
Darlene MONLISH - Clayton MO, US
Jane E. CAVANAUGH - Pittsburgh PA, US
Mattthew E. BUROW - Slidell LA, US
Steven ELLIOTT - New Orleans LA, US
Van T. HOANG - New Orleans LA, US

International Classification:

C07D 295/16
C07C 237/30
C07C 229/58

Abstract:

Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.