Veronica C Scott

US Patent:

20160039889, Feb 11, 2016

Filed:

Mar 14, 2014

Appl. No.:

14/774376

Inventors:

David WEINER - Merion PA, US
Veronica SCOTT - Philadelphia PA, US
Natalie HUTNICK - Malvern PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C07K 14/33
A61M 37/00
A61K 39/08

Abstract:

Disclosed herein are compositions and methods for treating neurotoxin intoxication and in particular, vaccines against the neurotoxin that provide protection again lethal challenge with neurotoxin from one or more serotypes of

US Patent:

20150079121, Mar 19, 2015

Filed:

Apr 10, 2013

Appl. No.:

14/391921

Inventors:

- Philadelphia PA, US
Daniel Choo - Lansdale PA, US
Karuppiah Muthumani - Cherry Hill NJ, US
Nyamekye Obeng-Adjei - Lansdowne PA, US
Veronica Scott - Philadelphia PA, US

International Classification:

C07K 14/005
A61K 39/155
A61K 39/39

US Classification:

4241861, 536 2372, 514 44 R, 530350, 4353201

Abstract:

Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that encodes consensus RSV F protein or immunogenic fragment thereof, sequences that encodes an RSV G(A) protein or immunogenic fragment thereof and sequences that encodes an RSV G(B) protein or immunogenic fragment thereof. Compositions comprising one, combinations of two or all three sequences are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Nucleic acid molecules and compositions comprising the chemokine CC20 and/or a consensus RSV M2-1 protein or immunogenic fragment thereof are also disclosed. Immunomodulatory methods and methods of inducing an immune response against RSV are disclosed. Method of preventing RSV infection and methods of treating individuals infected with RSV are disclosed.