Vidhya Gopalakrishnan

US Patent:

20060034903, Feb 16, 2006

Filed:

Aug 10, 2005

Appl. No.:

11/201625

Inventors:

Yuh-Fun Maa - Millbrae CA, US
Scott Sellers - San Mateo CA, US
Peter Daddona - Menlo Park CA, US
Marika Kamberi - San Jose CA, US
Vidhya Gopalakrishnan - San Jose CA, US
B. Silber - Palo Alto CA, US
Frank Stonebanks - Wayne PA, US

International Classification:

A61K 38/17
A61M 31/00
A61F 13/02

US Classification:

424448000, 514012000, 604500000

Abstract:

An apparatus and method for transdermally delivering a natriuretic peptide comprising a delivery system having a microprojection member that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the natriuretic peptide is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a natriuretic peptide-containing hydrogel formulation. In an alternative embodiment, the natriuretic peptide is contained in both the coating and the hydrogel formulation. In yet another embodiment, the natriuretic peptide is contained in a solid state formulation.