Vincent S Stoll

US Patent:

6518305, Feb 11, 2003

Filed:

Oct 19, 1999

Appl. No.:

09/422093

Inventors:

Clarence J. Maring - Palatine IL
Yuanwei Chen - North Haven CT
David A. Degoey - Kenosha WI
Vincent L. Giranda - Gurnee IL
David J. Grampovnik - Waukegan IL
Yu Gui Gu - Grayslake IL
Warren M. Kati - Gurnee IL
Dale J. Kempf - Libertyville IL
April Kennedy - Grayslake CO
Allan C. Krueger - Gurnee IL
Zhen Lin - Gurnee IL
Darold L. Madigan - Elk Grove Village IL
Steven W. Muchmore - Libertyville IL
Hing L. Sham - Mundelein IL
Kent D. Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Gary T. Wang - Niles IL
Sheldon Wang - Grayslake IL
Ming C. Yeung - Grayslake IL
Chen Zhao - Libertyville IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31195

US Classification:

514530, 514573, 548236, 548315, 5483451, 560122, 562504

Abstract:

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

US Patent:

6593314, Jul 15, 2003

Filed:

Sep 22, 2000

Appl. No.:

09/668245

Inventors:

Clarence J. Maring - Palatine IL
Vincent L. Giranda - Gurnee IL
Yu Gui Gu - Libertyville IL
Stephen Hanessian - Beaconsfield, CA
Dale J. Kempf - Libertyville IL
Darold L. Madigan - Elk Grove Village IL
Kent Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Gary T. Wang - Niles IL
Jianchio Wang - Montreal, CA
Chen Zhao - Libertyville IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31655

US Classification:

514151, 514183, 514529, 514563, 514567, 549512, 552 10, 560125, 562507

Abstract:

The present invention provides compounds of formula Ia and Ib or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, pharmaceutical formulations containing same, processes and intermediates for preparing said compounds, as well as methods of using said compounds, including preventing and treating diseases caused by microorganisms having said neuraminidase enzyme.

US Patent:

6831096, Dec 14, 2004

Filed:

Sep 24, 2002

Appl. No.:

10/253152

Inventors:

Clarence J. Maring - Palatine IL
Yu Gui Gu - Grayslake IL
Hui-Ju Chen - Grayslake IL
Yuanwei Chen - North Haven CT
David A. Degoey - Kenosha WI
William J. Flosi - Des Plaines IL
Vincent L. Giranda - Gurnee IL
David J. Grampovnik - Waukegan IL
Warren M. Kati - Gurnee IL
Dale J. Kempf - Libertyville IL
April Kennedy - Boulder CO
Larry L. Klein - Lake Forest IL
Allan C. Krueger - Gurnee IL
Zhen Lin - Gurnee IL
Darold L. Madigan - Elk Grove Village IL
Keith F. McDaniel - Wauconda IL
Steven W. Muchmore - Libertyville IL
Hing L. Sham - Mundelein IL
Kent D. Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Noah P. Tu - Gurnee IL
Frank L. Wagenaar - Gurnee IL
Gary T. Wang - Niles IL
Sheldon Wang - Grayslake IL
Paul E. Wiedeman - Deerfield IL
Yibo Xu - New Milford CT
Ming C. Yeung - Grayslake IL
Chen Zhao - Libertyville IL
Stephen Hanessian - Beaconsfield, CA
Malken Bayrakdarian - Verdun, CA
Xuehong Luo - Montreal, CA

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3140

US Classification:

514423

Abstract:

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

US Patent:

6831175, Dec 14, 2004

Filed:

Dec 12, 2002

Appl. No.:

10/317914

Inventors:

Qun Li - Libertyville IL
Keith W. Woods - Libertyville IL
John P. Fischer - Longmont CO
Jianchun Gong - Deerfield IL
Tongmei Li - Waukegan IL
Virajkumar Gandhi - Park City IL
Sheela A. Thomas - Libertyville IL
Garrick K. Packard - San Diego CA
Xiaohong Song - Park City IL
Jason N. Abrams - Des Plaines IL
Robert B. Diebold - Waukegan IL
Charles W. Hutchins - Green Oaks IL
Vincent S. Stoll - Libertyville IL
Saul H. Rosenberg - Grayslake IL
Vincent L. Giranda - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D21136

US Classification:

546187, 546193, 546194, 546199, 5462757, 514316, 514319, 514321

Abstract:

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

US Patent:

7378414, May 27, 2008

Filed:

Aug 24, 2004

Appl. No.:

10/925072

Inventors:

Douglas K. Hutchinson - Antioch IL, US
John R. Bellettini - Antioch IL, US
David A. Betebenner - Libertyville IL, US
Richard D. Bishop - Third Lake IL, US
Thomas B. Borchardt - Kenosha WI, US
Todd D. Bosse - Chicago IL, US
Russell D. Cink - Grayslake IL, US
Charles A. Flentge - Salem WI, US
Bradley D. Gates - Mount Prospect IL, US
Brian E. Green - Wonder Lake IL, US
Mira M. Hinman - Libertyville IL, US
Peggy P. Huang - Lake Bluff IL, US
Larry L. Klein - Lake Forest IL, US
Allan C. Krueger - Gurnee IL, US
Daniel P. Larson - Oak Creek WI, US
M. Robert Leanna - Grayslake IL, US
Dachun Liu - Waukegan IL, US
Darold L. Madigan - Elk Grove Village IL, US
Keith F. McDaniel - Wauconda IL, US
John T. Randolph - Libertyville IL, US
Todd W. Rockway - Grayslake IL, US
Teresa A. Rosenberg - Gurnee IL, US
Kent D. Stewart - Gurnee IL, US
Vincent S. Stoll - Libertyville IL, US
Rolf Wagner - Gurnee IL, US
Ming C. Yeung - Grayslake IL, US

Assignee:

Abbott Laboratories - Abbott park IL

International Classification:

C07D 285/26
A61K 31/549

US Classification:

5142232, 544 12

Abstract:

Compounds having the formula.

US Patent:

7538105, May 26, 2009

Filed:

Apr 4, 2008

Appl. No.:

12/098024

Inventors:

Douglas K. Hutchinson - Antioch IL, US
John R. Bellettini - Antioch IL, US
David A. Betebenner - Libertyville IL, US
Richard D. Bishop - Third Lake IL, US
Thomas B. Borchardt - Kenosha WI, US
Todd D. Bosse - Chicago IL, US
Russell D. Cink - Grayslake IL, US
Charles A. Flentge - Salem WI, US
Bradley D. Gates - Mount Prospect IL, US
Brian E. Green - Wonder Lake IL, US
Mira M. Hinman - Libertyville IL, US
Peggy P. Huang - Lake Bluff IL, US
Larry L. Klein - Lake Forest IL, US
Allan C. Krueger - Gurnee IL, US
Daniel P. Larson - Oak Creek WI, US
M. Robert Leanna - Grayslake IL, US
Dachun Liu - Waukegan IL, US
Darold L. Madigan - Elk Grove Village IL, US
Keith F. McDaniel - Wauconda IL, US
John T. Randolph - Libertyville IL, US
Todd W. Rockway - Grayslake IL, US
Teresa A. Rosenberg - Gurnee IL, US
Kent D. Stewart - Gurnee IL, US
Vincent S. Stoll - Libertyville IL, US
Rolf Wagner - Gurnee IL, US
Ming C. Yeung - Grayslake IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 513/04
A61K 31/542

US Classification:

5142228, 544 10

Abstract:

Compounds having the formula.

US Patent:

7662958, Feb 16, 2010

Filed:

Jul 13, 2007

Appl. No.:

11/777692

Inventors:

Rolf Wagner - Antioch IL, US
Pamela L. Donner - Mundelein IL, US
Dale J. Kempf - Libertyville IL, US
Clarence J. Maring - Palatine IL, US
Vincent S. Stoll - Libertyville IL, US
Yi-Yin Ku - Buffalo Grove IL, US
Yu-Ming Pu - Gurnee IL, US

International Classification:

C07D 498/02
C07D 417/04
A61K 31/549

US Classification:

544 10, 5142228

Abstract:

The present invention provides HCV polymerase inhibiting compounds having the formula (I):where Ris cyclobutyl-N(R)—, n is 1, 2, 3 or 4, and at least one Ris RSON(R)alkyl-. In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino])-4-hydroxy -2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methane-sulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.

US Patent:

7902203, Mar 8, 2011

Filed:

Oct 31, 2003

Appl. No.:

10/699513

Inventors:

John K. Pratt - Kenosha WI, US
David A. Betebenner - Libertyville IL, US
Pamela L. Donner - Mundelein IL, US
Brian E. Green - Wonder Lake IL, US
Dale J. Kempf - Libertyville IL, US
Keith F. McDaniel - Wauconda IL, US
Clarence J. Maring - Palatine IL, US
Vincent S. Stoll - Libertyville IL, US
Rong Zhang - Skokie IL, US
Hui-Ju Chen - Grayslake IL, US
William J. Flosi - Evanston IL, US
Larry L. Klein - Lake Forest IL, US
Allan C. Krueger - Gurnee IL, US
Dachun Liu - Waukegan IL, US
Darold L. Madigan - Elk Grove Village IL, US
Laura M. Maymon - Chicago IL, US
Todd W. Rockway - Grayslake IL, US
Kent D. Stewart - Gurnee IL, US
Ming C. Yeung - Grayslake IL, US
Qinghua Xie - Libertyville IL, US

Assignee:

Abbott Laboratories, Inc. - Abbott Park IL

International Classification:

A01N 43/54
A01N 43/90
C07D 285/00
C07D 285/22

US Classification:

5142581, 5142601, 514267, 544 3, 544 9, 544 10, 544 11, 544 12

Abstract:

The present invention provides an HCV polymerase inhibiting compound having the formula (I).