Vinh Q Tran

US Patent:

7067661, Jun 27, 2006

Filed:

Sep 3, 2003

Appl. No.:

10/653776

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Carmen S. Alvarez - Livingston NJ, US
Tin-Yau Chan - Edison NJ, US
Chad Knutson - Garwood NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Crambury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7074924, Jul 11, 2006

Filed:

Sep 3, 2003

Appl. No.:

10/653868

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Cranbury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7078525, Jul 18, 2006

Filed:

Sep 3, 2003

Appl. No.:

10/654157

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Cranbury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7084271, Aug 1, 2006

Filed:

Sep 3, 2003

Appl. No.:

10/654163

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Chad Knutson - Garwood NJ, US
Brian McKittrick - New Vernon NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Princeton NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7119200, Oct 10, 2006

Filed:

Feb 11, 2004

Appl. No.:

10/776988

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen S. Alvarez - Livingston NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin-Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar M. Hobbs - Somerville NJ, US
Douglas Walsh Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Cranbury NJ

International Classification:

C07D 487/04

US Classification:

544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7309705, Dec 18, 2007

Filed:

Mar 31, 2006

Appl. No.:

11/395824

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/519
A61P 35/00
C07D 484/04

US Classification:

51425931, 544281

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

7807683, Oct 5, 2010

Filed:

Mar 31, 2006

Appl. No.:

11/396001

Inventors:

Timothy J. Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael P. Dwyer - Scotch Plains NJ, US
Ronald J. Doll - Convent Station NJ, US
Viyyoor M. Girijavallabhan - Parsippany NJ, US
Alan Mallams - Hackettstown NJ, US
Carmen S. Alvarez - Livingston NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Jocelyn Rivera - Monmouth Junction NJ, US
Tin Yau Chan - Edison NJ, US
Vincent Madison - Mountain Lakes NJ, US
Thierry O. Fischmann - Scotch Plains NJ, US
Lawrence W. Dillard - Skillman NJ, US
Vinh D. Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray Anthony James - Bensalem PA, US
Haengsoon Park - Plainsboro NJ, US
Vidyadhar M. Paradkar - Somerville NJ, US
Douglas Walsh Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/519
A61P 35/04
A61P 35/02
C07D 487/04
A61P 35/00

US Classification:

5142593, 544281, 51426332, 51425217, 514183, 514 81, 514110, 5142342, 51425216, 514151, 514 8, 514 9, 514 27, 514167, 514 15, 514221, 514245, 424649, 424 944

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

US Patent:

20060173017, Aug 3, 2006

Filed:

Mar 31, 2006

Appl. No.:

11/395965

Inventors:

Timothy Guzi - Chatham NJ, US
Kamil Paruch - Garwood NJ, US
Michael Dwyer - Scotch Plains NJ, US
Ronald Doll - Convent Station NJ, US
Viyyoor Girijavallabhan - Parsippany NJ, US
Chad Knutson - Garwood NJ, US
Brian McKittrick - New Vernon NJ, US
Lawrence Dillard - Skillman NJ, US
Vinh Tran - Fountain Valley CA, US
Zhen Min He - Princeton NJ, US
Ray James - Bristol PA, US
Haengsoon Park - Plainsboro NJ, US

International Classification:

A61K 31/519
C07D 487/04

US Classification:

514252160, 544281000, 514259300

Abstract:

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.