Virginia B Fitzpatrick

US Patent:

20040235020, Nov 25, 2004

Filed:

Mar 5, 2004

Appl. No.:

10/793032

Inventors:

Michael Burczynski - Swampscott MA, US
Joseph Boni - Wayne PA, US
Andrew Dorner - Lexington MA, US
Natalie Twine - Goffstown NH, US
Jennifer Stover - Topsfield MA, US
William Trepicchio - Andover MA, US
Virginia Fitzpatrick - Norristown PA, US
Fred Immerman - Suffern NY, US

International Classification:

C12Q001/68
A61K038/17

US Classification:

435/006000, 514/012000

Abstract:

Methods, systems and equipment useful for monitoring in vivo activities of CCI-779 or other drugs. Numerous drug activity genes can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells are modulateable by CCI-779 or other drugs. Therefore, these genes can be used as surrogate markers for detecting or monitoring drug activities in vivo.