Virginia M Mosher

US Patent:

20100286066, Nov 11, 2010

Filed:

Feb 26, 2010

Appl. No.:

12/714432

Inventors:

Manzer Durrani - Plantation FL, US
Harish Kumar - Fullerton CA, US
Timothy Krieger - Richmond TX, US
Ken Kabingue - Los Angeles CA, US
Virginia Mosher - Lebanon MO, US
Philip J. Barr - Oakland CA, US
Ian C. Bathurst - Breitenbach, AT

International Classification:

A61K 38/14
A61K 38/02
A61P 11/00

US Classification:

514 209, 514 11

Abstract:

Alpha 1-antitrypsin compositions and treatment methods using such compositions for treating a variety of pulmonary diseases are provided. The compositions generally contain AAT, a stabilizing carbohydrate such as trehalose, a surfactant such as Polysorbate 80 and an antioxidant to stabilize AAT for use as a therapeutic. The formulations can be prepared as both liquids and solids and administered by nebulization of the liquid formulation or by conversion of dry powder formulation into an aerosol.

US Patent:

20080312136, Dec 18, 2008

Filed:

Nov 11, 2004

Appl. No.:

10/579088

Inventors:

Manzer Durrani - Plantation FL, US
Harish Kumar - Fullerton CA, US
Timothy Krieger - Lowell MA, US
Ken Kabingue - Los Angeles CA, US
Virginia Mosher - Lebanon MO, US
Philip J. Barr - Oakland CA, US
Ian C. Bathurst - Breitenbach, AT

International Classification:

A61K 38/55
A61P 11/00

US Classification:

514 8

Abstract:

Alpha 1-antitrypsin compositions and treatment methods using such compositions for treating a variety of pulmonary diseases are provided. The compositions generally contain AAT, a stabilizing carbohydrate such as trehalose, a surfactant such as Polysorbate 80 and an antioxidant to stabilize AAT for use as a therapeutic. The formulations can be prepared as both liquids and solids and administered by nebulization of the liquid formulation or by conversion of dry powder formulation into an aerosol.