A composition, and method for a targeted drug delivery is disclosed in treating central nervous system injury, including blast hearing loss, traumatic brain injury (TBI) and the like, by administering a subject with nanoparticle-based minocycline formulations. The formulation contains nanoparticles encapsulating minocycline for neuroprotective effect in TBI. Albumin nanoparticle-based minocycline formulations provide enhanced delivery to brain, and reduced toxicity at minimal dosage for treating a subject suffering from central nervous system injury including blast induced traumatic brain injury (bTBI). Nanoparticle administered at minimal dose in rat blast TBI model crossed blood-brain barrier (BBB) and enhanced therapeutic concentration compared to free minocycline. Provided is an effective and safe minocycline delivery in TBI with minimal or no toxicity for neuroprotective therapy. Studies indicate performance for behavioral (acute and chronic), pathological (chronic) and hearing loss mitigation using the disclosed drug and nanoparticles in rat moderate bTBI model.
Systems And Methods For Adapting Human Speaker Embeddings In Speech Synthesis
- San Francisco, US Xiaoyu LIU - San Mateo CA, US Michael Getty HORGAN - San Francisco CA, US Vivek Kumar - Foster City CA, US
Assignee:
DOLBY LABORATORIES LICENSING CORPORATION - San Francisco CA
International Classification:
G10L 13/033 G10L 13/047
Abstract:
Novel methods and systems for adapting a voice cloning synthesizer for a new speaker using real speech data are disclosed. Utterances from one or more target speakers are parameterized and are used to initialize an embedding vector for use with a voice synthesizer, by means of clustering the utterance data and determining the centroid of the data, using a speaker identification neural network, and/or by finding the closest stored embedded vector to the utterance data.
Flexible Embedding Systems And Methods For Real-Time Comparisons
- Bentonville AR, US Adrian Sonjong Yi - San Francisco CA, US Peng Yang - San Jose CA, US Valeriy Pelyushenko - San Jose CA, US Haibo Yan - San Bruno CA, US Vivek Kumar - Bellevue WA, US Jayanth Korlimarla - Sunnyvale CA, US Rajesh Garigipati - Dublin CA, US
International Classification:
G06N 20/00 G06F 16/903
Abstract:
Systems and methods for selecting items from a pool of items based on comparisons of composite embeddings are disclosed. A first initial embedding is obtained from a first database for each item in a pool of items and a second initial embedding is obtained from a second database for each item in the pool of items. The first initial embedding is generated using a first embedding model and the second initial embedding is generated using a second embedding model. A first composite embedding is generated for each item in the pool of items comprising the first initial embedding and the second initial embedding; and compare the first composite embedding for each item in the pool of items to a first anchor embedding, wherein the first anchor embedding comprises a first initial anchor embedding generated using the first embedding model and a second initial anchor embedding generated using the second embedding model.
A suction assembly, toothbrush, and method are provided that suction fluids and debris resulting from brushing. The suction assembly includes a housing configured to couple to the toothbrush so that a portion extends around sides and a back of the toothbrush head and is spaced from the toothbrush head by a gap. The suction assembly further includes a vacuum pump, a collection reservoir, and one or more conduits that couple the vacuum pump, suction head portion, and collection reservoir to apply a suction around the toothbrush head through the gap and deposit suctioned material in the collection reservoir.
Perceptually-Based Loss Functions For Audio Encoding And Decoding Based On Machine Learning
- San Francisco CA, US Grant A. DAVIDSON - Burlingame CA, US Chih-Wei WU - San Francisco CA, US Vivek KUMAR - Foster City CA, US
Assignee:
Dolby Laboratories Licensing Corporation - San Francisco CA
International Classification:
G10L 19/022 G06F 3/16 G06N 3/08 G06N 3/04
Abstract:
Computer-implemented methods for training a neural network, as well as for implementing audio encoders and decoders via trained neural networks, are provided. The neural network may receive an input audio signal, generate an encoded audio signal and decode the encoded audio signal. A loss function generating module may receive the decoded audio signal and a ground truth audio signal, and may generate a loss function value corresponding to the decoded audio signal. Generating the loss function value may involve applying a psychoacoustic model. The neural network may be trained based on the loss function value. The training may involve updating at least one weight of the neural network.
- Cambridge MA, US - Summit NJ, US Jorge Dimartino - Belmont CA, US Vivek Saroj Kumar Chopra - South San Francisco CA, US Kyle J. Macbeth - San Francisco CA, US Robert Douglas Knight - Berkeley Heights NJ, US Laurie Kenvin - New Hope PA, US Qiang Xu - Basking Ridge NJ, US
International Classification:
A61K 31/706 A61K 31/444 A61K 45/06 A61P 35/02
Abstract:
Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using a combination of an inhibitor of a mutant IDH1 enzyme and a DNA demethylating agent.
- San Francisco CA, US Michael Getty HORGAN - San Francisco CA, US Vivek KUMAR - Foster City CA, US Jaime H. MORALES - Alameda CA, US Cristina Michel VASCO - Austin TX, US
Assignee:
DOLBY LABORATORIES LICENSING CORPORATION - San Francisco CA
Computer-implemented methods for speech synthesis are provided. A speech synthesizer may be trained to generate synthesized audio data that corresponds to words uttered by a source speaker according to speech characteristics of a target speaker. The speech synthesizer may be trained by time-stamped phoneme sequences, pitch contour data and speaker identification data. The speech synthesizer may include a voice modeling neural network and a conditioning neural network.
Method And System For Integrating A Feedback Gathering System Over Existing Wifi Network Access
VIVEK KUMAR - murrysville PA, US DEEPENDRA TEWARI - GHAZIABAD, IN ASHIMA SOOD - LUDHIANA, IN
International Classification:
G06Q 30/02 H04W 60/00 G06Q 30/00 G06Q 50/12
Abstract:
In one aspect, a computerized process useful for integrating a feedback gathering mechanism into a captive-portal system provided over a radio wireless local area network, includes the step of detecting a user's computing device is connected to the captive-portal system of the radio wireless local area network. The process includes the step of providing a feedback form as an over a captive portal to the user's computing device. The feedback form comprises a set of multiple-choice questions answerable by a user. The process includes the step of linking the multiple-choice questions in a way such that the choice of answer for a question at any stage decides a subsequent question. The process includes the step of implicitly tying the multiple-choice questions to a specified set of categories.
2012 to 2000 Asst. Vice President, Pricing Operate ManagerGenworth Financial Richmond, VA 2009 to 2012 Program ManagerGenworth Financial (Mortgage) Raleigh, NC 2007 to 2008 Asst. Consultant (Sr. Business Analyst)GE Financial Assurance Richmond, VA 2001 to 2006 Sr. Systems AnalystAIG Consultants New York, NY 2000 to 2001 Senior Software EngineerDigerati, Melbourne, Australia
1998 to 1999 Software Engineer
Education:
DUKE UNIVERSITY, The Fuqua School of Business Durham, NC 2012 Master of Business Administration in FinanceKARNATAK UNIVERSITY, BVB College Hubli, Karnataka 1998 Bachelor of Science in Computer Science Engineering
Dr. Kumar graduated from the Lake Erie College of Osteopathic Medicine, Erie Campus in 1997. He works in Ellwood City, PA and 2 other locations and specializes in Cardiovascular Disease. Dr. Kumar is affiliated with Butler Memorial Hospital, Ellwood City Hospital, Lakewood Ranch Medical Center, Manatee Memorial Hospital and UPMC Mercy.
Acute Pancreatitis Anemia Cholelethiasis or Cholecystitis Constipation Diverticulitis
Languages:
English
Description:
Dr. Kumar graduated from the Maulana Azad Med Coll, Delhi Univ, New Delhi, Delhi, India in 2003. He works in Williamsport, PA and specializes in Gastroenterology. Dr. Kumar is affiliated with Williamsport Regional Medical Center.
American Board of Internal Medicine Sub-certificate in Cardiovascular Disease (Internal Medicine) American Board of Internal Medicine Sub-certificate in Interventional Cardiology (Internal Medicine)
Management Development Institute - MBA, Shanmugha Arts, Science, Technology & Research Academy - B.Tech, DAV JVM Shyamli - Computer Science, IIPS
Vivek Kumar
Work:
Schenck Rotec India Ltd - Chief of IT & Communiactions (2003) Indian Telephone Industries Ltd - STA (Prog) (1977-1988) Northern Digital Exchanges Ltd - Sr. Engineer (1988-1991) LML Ltd - Asstt Manager (1991-1993) Lohia Machines Ltd - Manager (1993-1999) Migra Electronics Ltd - Consultant (2000-2002)
Education:
Makatpur High School - General Subjects, Giridih College - PCM
About:
While looking back, the first place that I can view is- Giridih (I was born and brought up). I have not been stable yet: from Giridih to New Delhi to Allahabad to Chandigarh to Kanpur and then to Grea...
Bragging Rights:
Studied yet never tried to study!
Vivek Kumar
Work:
Edelman - Senior Account Director (2013) Adfactors PR - Head Servicing: Technology & Services Communications (2004-2013) 20:20 MEDIA (1992-2003)
Education:
The Doon School, Xavier Labour Relations Institute
Vivek Kumar
Work:
MphasiS
Education:
JNV Supaul, DPS Bokaro, AIT Ckm
Tagline:
Corporate Warrior
Vivek Kumar
Work:
IIA
Education:
Ignou - B.sc
About:
I am very practical, and only act after thinking things through. I don't like being forced to answer quickly. I have to evaluate the situation completely. I make decisions based on what I can veri...
Tagline:
I like working and being alone. I like to avoid attention at all costs. I tend to keep to it, and not interact much with the people around me
Bragging Rights:
Survided single
Vivek Kumar
Work:
Microsoft - Support Engineer
Education:
Indira college of commerce and science - Computer (BCA), DAV - 12th, Mount View School - Primary
Vivek Kumar
Work:
Royal Bank of Scotland - Associate (2010) Symphony Services - Senior Product Engineer (2008-2010) Fidelity Investments - Software Engineer (2005-2008)
Education:
Peoples Education Society Institute of Technology - Mechanical Engg.
Vivek Kumar
Work:
Apple Inc. - Marketer (2010) Cognizant Technology Solutions - Software engineer (2010-2011)
Education:
Anna University - IT
Tagline:
I am who I am underneath. But what I do, That defines me. ;) lolz
indows 10 Mail and Calendar will soon provide other features to Gmail users: easily tracking travel and shipping deliveries, making emails more actionable, helping you easily track your favorite sports events, faster search, and more, Vivek Kumar, Microsofts product marketing manager for Windows
Date: Apr 21, 2017
Category: Sci/Tech
Source: Google
Delhi High Court bombing is latest in a string of major attacks
The people collect there, and there is always a crowd, says lawyer Vivek Kumar. He described the scene that morning saying: I felt the tremors [from the bomb]. I saw dust blowing. I saw people running.
Date: Sep 07, 2011
Category: World
Source: Google
Youtube
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Vivek Kumar, IFFLA Patron
Red Carpet interview with another patron from our brand new patron pro...