Vivek Kumar

US Patent:

20220347193, Nov 3, 2022

Filed:

Apr 27, 2022

Appl. No.:

17/730358

Inventors:

- Newark NJ, US
Arun Reddy Ravula - Newark NJ, US
Namas Chandra - Newark NJ, US
Venkata Kakulavarapu RamaRao - Newark NJ, US
Vivek Kumar - Newark NJ, US
Zain Siddiqui - Paterson NJ, US

Assignee:

New Jersey Institute of Technology - Newark NJ

International Classification:

A61K 31/65
A61K 9/16
A61K 47/60
A61P 27/16
A61P 25/28
A61K 47/69
A61K 47/64

Abstract:

A composition, and method for a targeted drug delivery is disclosed in treating central nervous system injury, including blast hearing loss, traumatic brain injury (TBI) and the like, by administering a subject with nanoparticle-based minocycline formulations. The formulation contains nanoparticles encapsulating minocycline for neuroprotective effect in TBI. Albumin nanoparticle-based minocycline formulations provide enhanced delivery to brain, and reduced toxicity at minimal dosage for treating a subject suffering from central nervous system injury including blast induced traumatic brain injury (bTBI). Nanoparticle administered at minimal dose in rat blast TBI model crossed blood-brain barrier (BBB) and enhanced therapeutic concentration compared to free minocycline. Provided is an effective and safe minocycline delivery in TBI with minimal or no toxicity for neuroprotective therapy. Studies indicate performance for behavioral (acute and chronic), pathological (chronic) and hearing loss mitigation using the disclosed drug and nanoparticles in rat moderate bTBI model.

US Patent:

20220265643, Aug 25, 2022

Filed:

May 6, 2022

Appl. No.:

17/738301

Inventors:

- Bethesda MD, US
Vivek KUMAR - Baltimore MD, US
Anver Basha SHAIK - Baltimore MD, US

International Classification:

A61K 31/496
A61P 25/36
A61K 31/485

Abstract:

Disclosed herein are novel methods of treating pain in a patient in need thereof by providing to the patient a selective dopamine D3 receptor antagonist/partial agonist which when used with an opioid analgesic, can mitigate the development of opioid dependence, by preventing the need for dose escalation while either maintaining the opioid analgesic effect or providing analgesia with a lower dose of the opioid. In addition, the D3 antagonists/partial agonists described herein may be used to augment the effectiveness of current Medication Assisted Treatment regimens (e.g. methadone or buprenorphine) for the treatment of opioid use disorders.

US Patent:

20220185798, Jun 16, 2022

Filed:

Mar 3, 2022

Appl. No.:

17/685709

Inventors:

- Rockville MD, US
Vivek KUMAR - Baltimore MD, US
Anver Basha SHAIK - Baltimore MD, US

International Classification:

C07D 403/12
A61P 25/36
C07D 405/12

Abstract:

Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic tools. Also disclosed are methods of making the compounds.

US Patent:

20210346373, Nov 11, 2021

Filed:

Sep 9, 2019

Appl. No.:

17/265150

Inventors:

- Bethesda MD, US
Vivek KUMAR - Baltimore MD, US
Anver Basha SHAIK - Baltimore MD, US

International Classification:

A61K 31/496
A61K 31/485
A61P 25/36

Abstract:

Disclosed herein are novel methods of treating pain in a patient in need thereof by providing to the patient a selective dopamine D3 receptor antagonist/partial agonist which when used with an opioid analgesic, can mitigate the development of opioid dependence, by preventing the need for dose escalation while either maintaining the opioid analgesic effect or providing analgesia with a lower dose of the opioid. In addition, the D3 antagonists/partial agonists described herein may be used to augment the effectiveness of current Medication Assisted Treatment regimens (e.g. methadone or buprenorphine) for the treatment of opioid use disorders.

US Patent:

20210244173, Aug 12, 2021

Filed:

Jun 7, 2019

Appl. No.:

16/972954

Inventors:

- New Brunswick NJ, US
Vivek Ashok Kumar - Newark NJ, US

International Classification:

A46B 15/00
A46B 9/04
A46B 13/02
A46B 5/00
A61C 17/08
A61C 17/12
A61C 17/22

Abstract:

A suction assembly, toothbrush, and method are provided that suction fluids and debris resulting from brushing. The suction assembly includes a housing configured to couple to the toothbrush so that a portion extends around sides and a back of the toothbrush head and is spaced from the toothbrush head by a gap. The suction assembly further includes a vacuum pump, a collection reservoir, and one or more conduits that couple the vacuum pump, suction head portion, and collection reservoir to apply a suction around the toothbrush head through the gap and deposit suctioned material in the collection reservoir.

US Patent:

20200291000, Sep 17, 2020

Filed:

Sep 21, 2017

Appl. No.:

16/084093

Inventors:

- Bethesda MD, US
Vivek KUMAR - Baltimore MD, US
Anver Basha SHAIK - Baltimore MD, US

International Classification:

C07D 403/12
C07D 405/12
A61P 25/36

Abstract:

Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic tools. Also disclosed are methods of making the compounds.

US Patent:

20180308015, Oct 25, 2018

Filed:

Apr 19, 2018

Appl. No.:

15/957607

Inventors:

Vivek Ashok Kumar - Newark NJ, US
Vinicius Frigatti - Harrison NJ, US
Christopher Magesty - Kearny NJ, US
Jasper Davey - Bloomfield NJ, US
Dhruv Shah - Piscataway NJ, US
Peter Nguyen - New Rochelle NY, US

International Classification:

G06Q 10/02

Abstract:

The present disclosure relates to a system and method for soliciting offers and reservations for parking spots. The system and method is, in some instances, embodied as a mobile application that connects users to exchange the current physical space (e.g. parking spaces) in exchange for the same user's or another user's time, money, gratuity or service.