Vsevolod S Rakov

US Patent:

20140045273, Feb 13, 2014

Filed:

Jan 28, 2013

Appl. No.:

13/751871

Inventors:

Vsevolod Sergey Rakov - New Haven CT, US
Hayley E. Crowe - West Haven CT, US

Assignee:

PerkinElmer Health Sciences, Inc. - Waltham MA

International Classification:

G01N 27/62

US Classification:

436173, 422 83

Abstract:

Methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data corresponding to an unidentified chemical compound. By restricting the generation of candidate formulas to those having repeating units and/or end units with specified limitations, the methods and apparatus may more efficiently iteratively search for a chemical formula having matching mass spectrometry output within a threshold tolerance. In another aspect, methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data based at least in part upon neutral loss.

US Patent:

20110224104, Sep 15, 2011

Filed:

Jun 1, 2007

Appl. No.:

11/757020

Inventors:

Evgenia Razumovski - Columbia MD, US
Berk Oktem - Columbia MD, US
Appavu K. Sundaram - Montgomery Village MD, US
Vsevolod S. Rakov - New Haven CT, US
Sudeepta Shanbhag - Ellicott City MD, US
Sergey Kurnosenko - Fairfax VA, US
Vladimir M. Doroshenko - Ellicott City MD, US

Assignee:

Science & Engineering Services, Inc. - Columbia MD

International Classification:

C40B 50/06
C12Q 1/04
C12M 1/34
C40B 60/14

US Classification:

506 26, 435 34, 4352871, 506 40

Abstract:

A method and system for identification of microorganisms in a sample. The method includes processing the sample to produce at least one group of biomarker molecules from at least one microorganism in the sample, tandem mass-analyzing biomarker fragment ions from the at least one group of biomarker molecules to obtain a sample biomarker tandem mass spectrum of the biomarker, and identifying the microorganism in the sample based on a comparison of the sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum (stored in the reference library) from a known microorganism. The system includes a sample processing unit configured to process the sample and produce at least one group of biomarker molecules from at least one microorganism in the sample. The system includes a mass-analyzer for tandem mass analysis biomarker fragment ions. The system includes a processor configured to identify the microorganism in the sample based on a comparison of a sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum from a known microorganism.

US Patent:

20170004289, Jan 5, 2017

Filed:

Jun 30, 2016

Appl. No.:

15/198755

Inventors:

- Waltham MA, US
Vsevolod Sergey Rakov - New Haven CT, US
Hayley E. Crowe - West Haven CT, US

International Classification:

G06F 19/00
G01N 27/62

Abstract:

Methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data corresponding to an unidentified chemical compound. By restricting the generation of candidate formulas to those having repeating units and/or end units with specified limitations, the methods and apparatus may more efficiently iteratively search for a chemical formula having matching mass spectrometry output within a threshold tolerance. In another aspect, methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data based at least in part upon neutral loss.