Wallace T Ashton

US Patent:

7026316, Apr 11, 2006

Filed:

Mar 22, 2002

Appl. No.:

10/472771

Inventors:

Wallace T. Ashton - Edison NJ, US
Charles G. Caldwell - Scotch Plains NJ, US
Hyun O. Ok - Edison NJ, US
Emma R. Parmee - Scotch Plains NJ, US
Ann E. Weber - Scotch Plains NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/426
A61K 31/40
C07D 207/00
C07D 277/04
C07D 417/04

US Classification:

514242, 514326, 514365, 514397, 514423, 546209, 5462697, 5462704, 548181, 548200, 5483147, 548540

Abstract:

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

7238683, Jul 3, 2007

Filed:

Oct 29, 2004

Appl. No.:

10/573108

Inventors:

Wallace T. Ashton - Edison NJ, US
Hong Dong - Livingston NJ, US
Jinyou Xu - Scotch Plains NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 207/04
C07D 401/10
C07D 403/10
C07D 487/04
A61K 31/40
A61K 31/4439
A61K 31/454
A61K 31/437
A61K 31/4985
A61K 31/506
A61K 31/4725
A61P 3/10

US Classification:

51421017, 51421018, 514249, 514274, 514319, 514343, 514423, 544316, 544350, 546119, 546205, 5462791, 546141, 548540, 548953

Abstract:

The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

7265128, Sep 4, 2007

Filed:

Jan 13, 2004

Appl. No.:

10/542214

Inventors:

Wallace T. Ashton - Edison NJ, US
Charles G. Caldwell - Scotch Plains NJ, US
Robert J. Mathvink - Red Bank NJ, US
Hyun O. Ok - Colonia NJ, US
Leah Bitalac Reigle - Dayton NJ, US
Ann E. Weber - Scotch Plains NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/4365
C07D 513/04

US Classification:

514301, 546114, 546113, 546115, 546117, 546118, 546120, 514300, 514302, 514303

Abstract:

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

7388019, Jun 17, 2008

Filed:

Jan 27, 2004

Appl. No.:

10/542694

Inventors:

Wallace T. Ashton - Edison NJ, US
Charles G. Caldwell - Scotch Plains NJ, US
Joseph L. Duffy - Cranford NJ, US
Robert J. Mathvink - Red Bank NJ, US
Liping Wang - Dayton NJ, US
Ann E. Weber - Scotch Plains NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 471/04
A61K 31/4375
A61P 3/10
C07D 487/04
A61K 31/4985
A61K 31/5025
A61K 31/519
A61K 31/53

US Classification:

514300, 546122, 544179, 544180, 544184, 544239, 544279, 544350, 514241, 514243, 51425203, 514249, 5142661

Abstract:

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

7625888, Dec 1, 2009

Filed:

Aug 19, 2005

Appl. No.:

11/660130

Inventors:

Ann E. Weber - Scotch Plains NJ, US
Wallace T. Ashton - Edison NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 471/00
C07D 487/00
A61K 31/44
A61K 31/495
A61K 31/55
A61P 3/00

US Classification:

51421111, 51421402, 514220, 514250, 514257, 514293, 540548, 540562, 540586, 544251, 544346, 546 82

Abstract:

The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

7956061, Jun 7, 2011

Filed:

Jan 18, 2006

Appl. No.:

11/793093

Inventors:

Wallace T. Ashton - Edison NJ, US
Charles G. Caldwell - Dallas TX, US
Hong Dong - Livingston NJ, US
Giovanna Scapin - Staten Island NY, US
Ann E. Weber - Scotch Plains NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 487/04
A61K 31/519
A61P 3/10

US Classification:

5142593, 544281, 544263

Abstract:

The present invention is directed to novel substituted bicyclic pyrimidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

40790690, Mar 14, 1978

Filed:

May 9, 1977

Appl. No.:

5/794771

Inventors:

Donald W. Graham - Mountainside NJ
Edward F. Rogers - Middletown NJ
Wallace T. Ashton - Clark NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31505
C07D52100

US Classification:

2602564F

Abstract:

5-Deazariboflavin, its phosphate ester and nontoxic salts thereof and its novel bis(loweralkoxymethylene) derivatives have antiprotozoal and antiparasitic activity. They are particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance. The compounds are included in compositions useful for the prevention and treatment of coccidiosis in poultry.

US Patent:

51871793, Feb 16, 1993

Filed:

Mar 22, 1991

Appl. No.:

7/673630

Inventors:

Wallace T. Ashton - Clark NJ
Steven M. Hutchins - Iselin NJ
Malcolm MacCoss - Freehold NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3141
C07D24908
C07D27910
C07D41310

US Classification:

514383

Abstract:

There are disclosed substituted imidazo[1,2-b][1,2,4]triazole derivatives of Formula I which are useful as angiotensin II antagonists. ##STR1##.