Walter E Rogers

US Patent:

51165996, May 26, 1992

Filed:

Jul 31, 1989

Appl. No.:

7/388049

Inventors:

Walter J. Rogers - Ellicott City MD
Thomas S. Everett - Lutherville MD

Assignee:

Johns Hopkins Univ. - Baltimore MD
Towson State Univ. - Lutherville MD

International Classification:

G01N 3100
G01N 2400
C07H 100
C07H 1500

US Classification:

424 9

Abstract:

Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance.

US Patent:

54771447, Dec 19, 1995

Filed:

Feb 18, 1993

Appl. No.:

8/019354

Inventors:

Walter J. Rogers - Ellicott City MD

Assignee:

Johns Hopkins University - Baltimore MD

International Classification:

G01V 300
G01V 500
G01V 700

US Classification:

324309

Abstract:

A method for removing image artifacts in MRI created when data acquisition is synchronized to a physiological and therefore uneven intervals. The method simultaneously records both image data from the MRI scanner as well as the exact interval between each data acquisition. The image data is then modified according to the timing file to create a image data file free from signal variations and artifacts resulting from the uneven data sampling intervals.

US Patent:

52346803, Aug 10, 1993

Filed:

Sep 19, 1991

Appl. No.:

7/762445

Inventors:

Walter J. Rogers - Ellicott City MD
Thomas S. Everett - Lutherville MD

Assignee:

Johns Hopkins Univ. - Baltimore MD
Towson State University - Lutherville MD

International Classification:

G01N 2408
G12Q 156
A61K 3700
C07C21100

US Classification:

424 9

Abstract:

The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects.

US Patent:

53975634, Mar 14, 1995

Filed:

Mar 1, 1994

Appl. No.:

8/203945

Inventors:

Walter J. Rogers - Ellicott City MD
Thomas S. Everett - Lutherville MD

Assignee:

The Johns Hopkins University - Baltimore MD
Towson State University - Towson MD

International Classification:

A61B 5055
C07J 5100

US Classification:

424 9

Abstract:

Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for easy detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any chance of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects.