Warren H Manning

US Patent:

8457711, Jun 4, 2013

Filed:

Jan 30, 2008

Appl. No.:

12/011992

Inventors:

Reza Nezafat - Newton MA, US
Warren Manning - Natick MA, US

Assignee:

Beth Israel Deaconess Medical Center, Inc. - Boston MA

International Classification:

A61B 5/05

US Classification:

600410, 600407, 600413

Abstract:

A method and system for magnetic resonance imaging comprises applying at least one radiofrequency magnetization transfer (MT) pulse to a coronary venous region of a subject positioned within a magnetic field, and acquiring magnetic resonance imaging data from the coronary venous region to produce an image of a coronary venous structure. This technique can be utilized as part of a 3D free-breathing, ECG-triggered gradient-echo Cartesian acquisition of the coronary region. One or more magnetization transfer (MT) preparation pulses are used to enhance the contrast between venous blood and myocardium. The MT preparation results in myocardial signal suppression without any significant signal loss in the arterial or venous blood so as to maintain venous blood signal-to-noise ratio while improving contrast between myocardium and veins. The image of a coronary venous structure can be acquired in connection with an interventional cardiovascular procedure, such as a cardiac resynchronization therapy.

US Patent:

6501979, Dec 31, 2002

Filed:

Mar 9, 2000

Appl. No.:

09/521714

Inventors:

Warren J. Manning - Boston MA
Rene M. Botnar - Brookline MA
Matthias Stuber - Brookline MA

Assignee:

Koninklijke Philips Electronics N.V. - Eindhoven

International Classification:

A61B 5055

US Classification:

600413, 600428

Abstract:

This invention relates to methods and apparatus for medical imaging of parts of a patient in which imaging data acquisition is gated by a combination of electrocardiogram (ECG) and peripheral pulse (PPU) signals from the patient. The methods of the invention include obtaining ECG signals from a patient in a medical imaging apparatus, obtaining PPU signals from the patient, providing one or more synchronization signals in dependence on both the ECG signals and the PPU signals, wherein the synchronization signals indicate occurrences of pre-determined phases of the cyclic movements of the heart only if the PPU signals also indicate that the determined heart phase is physiologically possible, and controlling the medical imaging apparatus in dependence on the synchronization signals to collect imaging data synchronized with cyclic movements of the heart from the patient in the examination zone and to reconstruct a medical image of a part of the patient from the collected imaging data. The medical imaging apparatus of the invention includes such units in addition to the imaging units as are necessary from the practice of the methods of the invention. This invention is preferably applied to magnetic resonance imaging and to computed tomographic x-ray imaging.

US Patent:

20150276909, Oct 1, 2015

Filed:

May 9, 2014

Appl. No.:

14/274065

Inventors:

- Boston MA, US
Reza NEZAFAT - Newton MA, US
Warren J. MANNING - Natick MA, US

Assignee:

Beth Israel Deaconess Medical Center, Inc. (BIDMC, INC.) - Boston MA

International Classification:

G01R 33/567
G01R 33/48
G01R 33/563
A61B 5/055

Abstract:

A method and apparatus for MRI retrospective reconstruction determines a period of minimal coronary artery motion within the acquired temporal window with a rotation angle optimized for a K-space four-dimensional (4D) volume by a segmented 4D radial stack-of-stars (SOS) acquisition during a temporal acquisition window (taw). Radial stacks of the image of an object are acquired by performing the radial (SOS) acquisition to determine a plurality of kplane samples of the object, in which each kplane is repeatedly determined during a sub-window of the temporal acquisition window. Consecutive volumes of kcentric slices of the image at each temporal sub-window of the temporal acquisition window are generated and summed to fill a 3D k-space volume. The radial (SOS) acquisition of the image is determined utilizing a customized rotation angle θ providing a uniform distribution of k-space spokes of the kcentric slices for each sub-window of the (taw).

US Patent:

20150268320, Sep 24, 2015

Filed:

Mar 20, 2015

Appl. No.:

14/663994

Inventors:

- Boston MA, US
Tamer BASHA - Revere MA, US
Warren J. MANNING - Natick MA, US
Reza NEZAFAT - Waban MA, US

Assignee:

BETH ISRAEL DEACONESS MEDICAL CENTER, INC. - Boston MA

International Classification:

G01R 33/50
G01R 33/48
G01R 33/567
G01R 33/36
G01R 33/563
G01R 33/56

Abstract:

An MRI apparatus includes: a data processor configured to acquire a first set of T-weighted imaging data and a second set of T-weighted imaging data; a pulse sequence controller configured to generate a pulse sequence and apply the generated pulse sequence to a gradient coil assembly and RF coil assembly, the generated pulse sequence including: T-preparation modules and associated imaging modules to acquire the first set of T-weighted imaging data, and a saturation pulse sequence and an associated saturation imaging module to acquire the second set of T-weighted imaging data; a curve fitter configured to apply the first and second sets of T-weighted imaging data to a three-parameter model for Tdecay, to determine a Tvalue at a plurality of locations; and an image processor configured to generate a Tmap of the object based on the Tvalue determined at the plurality of locations.

US Patent:

20150161789, Jun 11, 2015

Filed:

Dec 9, 2014

Appl. No.:

14/564802

Inventors:

Sébastien Roujol - Brookline MA, US
Warren J. Manning - Natick MA, US
Reza Nezafat - Newton MA, US

International Classification:

G06T 7/00
G06K 9/46
G06K 9/62
G06T 7/20

Abstract:

Systems and methods for adaptively registering images acquired with different contrast-weightings using a magnetic resonance imaging (“MRI”) system. For instance, motion is estimated as global affine motion refined by a local non-rigid motion estimation algorithm that simultaneously estimates the motion field and intensity variations among the images being registered. The images registered with the described systems and methods can be used for improved tissue characterization.

US Patent:

20140200436, Jul 17, 2014

Filed:

Jan 16, 2013

Appl. No.:

13/742620

Inventors:

Sebastian Weingärtner - Heidelberg, DE
Mehmet Akçakaya - Cambridge MA, US
Warren J. Manning - Natick MA, US
Reza Nezafat - US MA, US

International Classification:

A61B 5/055

US Classification:

600413

Abstract:

A system and method for controlling a magnetic resonance imaging (MRI) system to acquire images of a subject having inconsistencies in a cardiac cycle of the subject. The process includes receiving an identification of a predetermined point in a cardiac cycle of the subject and, thereupon, performing a saturation module configured to dephase magnetization within a region of interest (ROI) from before the predetermined point. The process also includes performing an inversion module configured to invert spins within the ROI and acquiring medical imaging data from the subject. A delay is inserted between the performance of the saturation module and the performance of the inversion module, wherein a duration of the delay is configured, with the saturation module, to control evidence in the medical imaging data of inconsistencies in the cardiac cycle of the subject by controlling a magnetization history of tissue in the ROI.