Wei A Chang

US Patent:

6498168, Dec 24, 2002

Filed:

Jul 11, 2001

Appl. No.:

09/902849

Inventors:

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D40102

US Classification:

514316, 546186, 546187, 546188, 546189

Abstract:

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R , R , R , R , R , R , R , X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimers disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

US Patent:

49962027, Feb 26, 1991

Filed:

Oct 17, 1985

Appl. No.:

6/788274

Inventors:

Joel G. Berger - Cedar Grove NJ
Wei K. Chang - Livingston NJ
Elijah H. Gold - West Orange NJ
Arthur J. Elliott - Sloatsburg NY

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D22316
C07D41304
C07D40304
A61K 3155

US Classification:

514213

Abstract:

Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in treating mental disorders and which have activities of prolonged duration are disclosed. Methods for preparing these compounds and methods for their use are also described.

US Patent:

53747224, Dec 20, 1994

Filed:

Mar 16, 1993

Appl. No.:

8/027167

Inventors:

Joel G. Berger - Cedar Grove NJ
Wei K. Chang - Livingston NJ
John W. Clader - Cranford NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D22314
C07D22316
C07D22318

US Classification:

540581

Abstract:

The compound ##STR1## is useful as an agent in the treatment of psychoses and drug dependence and for providing an analgesic effect.

US Patent:

52410650, Aug 31, 1993

Filed:

Feb 25, 1992

Appl. No.:

7/841603

Inventors:

Joel G. Berger - Cedar Grove NJ
Wei K. Chang - Livingston NJ
Joseph A. Kozlowski - Plainsboro NJ
Guowei Zhou - West Orange NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D22316
A61K 3155

US Classification:

540523

Abstract:

A novel process for the preparation of. alpha. -substituted arylacetamides wherein the substituent is an aromatic group or a 1-alkenyl or 1-cycloalkenyl group and wherein the nitrogen atom carries no hydrogen atoms comprises the reaction of an arylacetamide having one or two hydrogen atoms on the. alpha. -carbon atom, wherein the nitrogen atom carries no hydrogen atoms, with a strong base in an inert aprotic organic solvent, followed by reaction with a zerovalent transition metal catalyst and then with a compound of the formula R. sup. 4 --X, wherein R. sup. 4 is selected from aromatic groups, 1-alkenyl groups and 1-cycloalkenyl groups and X is a particular leaving group, especially a triflate group. The. alpha. -substituted arylacetamides are useful as intermediates in the preparation (by reduction) of. alpha. -substituted arylethylamines, e. g.

US Patent:

55301258, Jun 25, 1996

Filed:

Aug 19, 1994

Appl. No.:

8/290894

Inventors:

Joel G. Berger - Cedar Grove NJ
Wei K. Chang - Livingston NJ
Joseph A. Kozlowski - Plainsboro NJ
Guowei Zhou - Livingston NJ

Assignee:

Schering Corportion - Kenilworth NJ

International Classification:

C07D20934
C07D21724
C07D22316

US Classification:

540594

Abstract:

A novel process for the preparation of. alpha. -substituted arylacetamides wherein the substituent is an aromatic group or a 1-alkenyl or 1-cycloalkenyl group and wherein the nitrogen atom carries no hydrogen atoms comprises the reaction of an arylacetamide having one or two hydrogen atoms on the. alpha. -carbon atom, wherein the nitrogen atom carries no hydrogen atoms, with a strong base in an inert aprotic organic solvent, followed by reaction with a zerovalent transition metal catalyst and then with a compound of the formula R. sup. 4 --X, wherein R. sup. 4 is selected from aromatic groups, 1-alkenyl groups and 1-cycloalkenyl groups and X is a particular leaving group, especially a triflate group. The. alpha. -substituted arylacetamides are useful as intermediates in the preparation (by reduction) of. alpha. -substituted arylethylamines, e. g.

US Patent:

50156390, May 14, 1991

Filed:

Mar 13, 1989

Appl. No.:

7/322801

Inventors:

Joel G. Berger - Cedar Grove NJ
Wei K. Chang - Livingston NJ
Marjorie Peters - Saint Simons Island GA

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 3155
A61K 31495
C07D40302
C07D22316

US Classification:

514213

Abstract:

Disclosed herein are novel 1-substituted-2,3,4,5-tetrahydro-1H-3-benzazepines of the general formula I: ##STR1## wherein R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4 and R. sup. 5 are specified substituents. R. sup. 1 is preferably --X. sup. 6, --CHR. sup. 7 R. sup. 8, cycloalkyl, cycloalkenyl, ##STR2## or pyrrolyl where m is 1, R. sup. 6 represents. dbd. H, phenyl, substituted phenyl, aralkyl, alkyl, cycloalkyl, haloalkyl or alkoxyalkyl, R. sup. 7 represents H or alkyl preferably H, R. sup. 8 represents cycloalkyl, cycloalkenyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl and R. sup. 9 represents alkyl, aloxy or alkoxyalkyl. R. sup. 2 preferably represents --H and R. sup. 3 --CH. sub. 3, and R. sup. 4 is preferably halogen and R. sup. 5 is preferably OH, OCO. R. sup.

US Patent:

58830960, Mar 16, 1999

Filed:

Feb 16, 1996

Appl. No.:

8/602403

Inventors:

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W. Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D29508
C07D30781
C07D33358
A61K 31495

US Classification:

514252

Abstract:

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds of formula I ##STR1## wherein one of Y and Z is N and the other is N, CH, or C-alkyl; X is --O--, --SO. sub. 0-2 --, amino, substituted amino, --CO--, --CH. sub. 2 --, mono or di-substituted methylene, --CS--, --CONR. sup. 20 --, --NR. sup. 20 --SO. sub. 2 --, --NR. sup. 20 CO--, --SO. sub. 2 NR. sup. 20 --, --CH. dbd. CH--, --C. tbd. C-- or --NHC(O)NH--; R is optionally substituted phenyl, aryl or cycloalkyl, or other substituents as defined in the specification; R. sup. 1 and R. sup. 21 are H, CN or optionally substituted alkyl, or other substituents as defined in the specification; R. sup. 2 is optionally substituted cycloalkyl or piperidyl, or other substituents as defined in the specification; and R. sup. 3, R. sup. 4, R. sup. 5, R. sup. 20, R. sup. 27 and R. sup. 28 are as defined in the specification; are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease; pharmaceutical compositions and methods of preparation are also disclosed, as well as synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

US Patent:

49735861, Nov 27, 1990

Filed:

Jul 18, 1988

Appl. No.:

7/223739

Inventors:

Joel G. Berger - Cedar Grove NJ
Wei K. Chang - Livingston NJ
Elijah H. Gold - West Orange NJ
John W. Clader - Cranford NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D49104
C07D22314
A61K 3155

US Classification:

514217

Abstract:

Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.