Wei He

US Patent:

6344198, Feb 5, 2002

Filed:

Jul 27, 1998

Appl. No.:

09/123386

Inventors:

Wei W. He - Columbia MD
Paul S. Meissner - Barnesville MD
Peter L. Hudson - Germantown MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 39395

US Classification:

4241391, 4241301, 4241331, 4241381, 4241411, 4241421, 4241431, 4241521, 4241721, 4241741, 5303871, 5303877, 5303881, 53038815, 5303873, 5303888

Abstract:

A human prostatic specific reductase polypeptide and polynucleotides encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides as a diagnostic marker for prostate cancer and as an agent to determine if the prostate cancer has metastasized. Also disclosed are antibodies specific to the prostatic specific reductase polypeptide which may be used to target prostate cancer cells and be used as part of a prostate cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

US Patent:

6495519, Dec 17, 2002

Filed:

Jul 28, 1998

Appl. No.:

09/124934

Inventors:

Wei Wu He - Columbia MD
Craig A. Rosen - Laytonsville MD
Peter L. Hudson - Germantown MD
Gregg A. Hastings - Rockville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3848

US Classification:

514 12, 435226, 435219, 424 9463, 424 9465, 530350

Abstract:

Disclosed are human interleukin-1 converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimers disease, Parkinsons disease, rheumatoid arthritis and head injury.

US Patent:

6500638, Dec 31, 2002

Filed:

Jul 28, 1999

Appl. No.:

09/361741

Inventors:

Peter L. Hudson - Germantown MD
Craig A. Rosen - Laytonsville MD
Wei Wu He - Columbia MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3817

US Classification:

435 691, 435 697, 4353201, 435325, 514 2, 514 12, 530350

Abstract:

The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using such polypeptides therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.

US Patent:

6521227, Feb 18, 2003

Filed:

Dec 18, 1999

Appl. No.:

09/461418

Inventors:

Peter L. Hudson - Germantown MD 20874
Craig A. Rosen - Laytonsville MD 20882
Wei Wu He - Columbia MD 21045

International Classification:

A61K 3942

US Classification:

4241331, 4241351, 4241391, 4241451, 5303873, 5303881, 53038824, 5303892

Abstract:

The present invention relates to human PGF polypeptides, DNA (RNA) encoding such polypeptides, and antibodies specifically binding such polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques, and for producing antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using the polypeptide therapeutically for treating prostate cancer, promoting tissue regeneration, and facilitating wound healing. Further provided are methods of using such antibodies therapeutically to inhibit the action of PGF polypeptides and for the treatment of PGF-dependent tumors. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.

US Patent:

6538121, Mar 25, 2003

Filed:

Nov 1, 1994

Appl. No.:

08/334251

Inventors:

Wei Wu He - Columbia MD
Craig A. Rosen - Laytonsville MD
Peter L. Hudson - Germantown MD
Gregg A. Hastings - Rockville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C15N 1557

US Classification:

536 232, 536 235, 435 691, 435226, 4353201

Abstract:

Disclosed are human interleukin-1 converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimers disease, Parkinsons disease, rheumatoid arthritis and head injury.

US Patent:

6656743, Dec 2, 2003

Filed:

Jun 24, 2002

Appl. No.:

10/177158

Inventors:

Peter L. Huson - Germantown MD
Wei Wu He - Columbia MD
Craig A. Rosen - Laytonsville MD
Jeannine D. Gocayne - Potomac MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 910

US Classification:

436193

Abstract:

Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimers Disease, ALS and other cholinergic defects, and antagonists for treating Parkinsons Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.

US Patent:

6733981, May 11, 2004

Filed:

Jul 2, 2001

Appl. No.:

09/895263

Inventors:

Wei Wu He - Columbia MD
Craig A. Rosen - Laytonsville MD
Peter L. Hudson - Germantown MD
Gregg A. Hastings - Westlake Village CA

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12P 2108

US Classification:

435 71, 435 7021, 530350, 5303871, 5303873, 53038815, 53038826, 5303891, 5303913

Abstract:

Disclosed are human interlude-1 converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimers disease, Parkinsons disease, rheumatoid arthritis and head injury.

US Patent:

7026140, Apr 11, 2006

Filed:

Sep 2, 2004

Appl. No.:

10/932269

Inventors:

Peter L. Hudson - Germantown MD, US
Wei Wu He - Columbia MD, US
Steven M. Ruben - Brookville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12Q 1/70
C12N 5/12
C12N 9/00
C12P 21/08

US Classification:

435 7021, 435 5, 435183, 435326, 530350, 530809, 53038826

Abstract:

Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.