Wei Li Li

US Patent:

8303946, Nov 6, 2012

Filed:

Sep 2, 2003

Appl. No.:

10/654273

Inventors:

Margo A. Brinton - Decatur GA, US
Wei Li - Wayland MA, US

Assignee:

Georgia State University Foundation, Inc. - Atlanta GA

International Classification:

C12N 15/00
C12N 15/33
C12N 15/86
C12Q 1/68
C12Q 1/70

US Classification:

424 931, 424 9321, 424 932, 435456, 435 5, 435 61

Abstract:

The present invention is directed to methods and compositions that are effective in the inhibition of viral replication. In particular, the methods and compositions are effective at interfering with the activity of host cell proteins required in viral replication. For example, an embodiment of the invention is directed to inhibition of flavivirus replication wherein the replication is effected by changing the normal interactions of the host cell protein TIAR or TIA-1.

US Patent:

20100166704, Jul 1, 2010

Filed:

Apr 7, 2008

Appl. No.:

12/082095

Inventors:

Margo A. Brinton - Decatur GA, US
Mohamed M. Emara - Roswell GA, US
Wei Li - Wayland MA, US

International Classification:

A61K 38/21
A61K 39/395
A61K 35/76
A61K 38/00
A61K 38/16
A61K 31/7088

US Classification:

424 854, 4241301, 424 936, 514 2, 514 12, 514 44 R

Abstract:

The present invention is directed to methods and compositions that are effective in the inhibition of viral replication. In particular, the methods and compositions are effective at interfering with the activity of host cell proteins required in viral replication. For example, an embodiment of the invention is directed to inhibition of flavivirus replication wherein the replication is affected by changing the normal interactions of the host cell protein TIAR or TIA-1.

US Patent:

20110269713, Nov 3, 2011

Filed:

Oct 14, 2010

Appl. No.:

12/937793

Inventors:

Gary E. Keck - Salt Lake City UT, US
Matthew B. Kraft - Salt Lake City UT, US
Anh P. Truong - Burlingame CA, US
Carina C. Sanchez - Somerville MA, US
Wei Li - Salt Lake City UT, US
Jonathan A. Covel - San Diego CA, US
Dennie Welch - Lake Bluff IL, US
Yam Poudel - Salt Lake City UT, US

Assignee:

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

International Classification:

A61K 31/695
C07D 309/22
A61P 37/00
A61K 31/351
A61P 35/00
A61P 25/28
C07F 7/08
C07D 323/00

US Classification:

514 63, 549214, 549427, 549417, 549267, 514451, 514450

Abstract:

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.

US Patent:

20220202984, Jun 30, 2022

Filed:

Mar 15, 2022

Appl. No.:

17/695112

Inventors:

- Norcross GA, US
Wei Li - Norcross GA, US
Yuan Di - Norcross GA, US
Annie You - Norcross GA, US
Low Wee Fong - Singapore, SG

International Classification:

A61L 9/22
A61L 9/20
A61L 2/10
A61L 2/24
A61L 2/26

Abstract:

A germicidal device includes a purification/disinfection and LED lighting member configured to generate UVC light and negative air ions for destroying microorganisms and removing odors in a space in which the purification and sterilization member is placed; a sensing member configured to detect at least one event occurred in said space in real time; and a microcontroller unit coupled with the purification and sterilization member and the sensing member for controlling operations of the purification and sterilization member in a respective state in accordance with the at least one event occurred in said space and energy saving. The UVC light has one or more wavelengths in a range of about 100-400 nm.

US Patent:

20200309991, Oct 1, 2020

Filed:

Sep 11, 2017

Appl. No.:

16/091481

Inventors:

- Houston TX, US
Wei Li - Houston TX, US
Donald Douglas Nelson - Highlands Ranch CO, US

Assignee:

Landmark Graphics Corporation - Houston TX

International Classification:

G01V 99/00
G06T 17/05
G06T 7/50
G06Q 10/04

Abstract:

A method and a system for modeling a three-dimensional geological structure. A method may comprise selecting input data from well measurement systems, seismic surveys or other sources, inputting the input data into an information handling system, building a quotient space, projecting constraints to the quotient space, constructing depth functions on the quotient space, trimming against a fault network, and producing a three-dimensional model of horizons. A system may comprise a downhole tool. The downhole tool may comprise at least one receiver and at least one transmitter. The system may further comprise a conveyance and an information handling system. The information handling system may be configured to select an input data, build a quotient space, project constraints to the quotient space, construct depth functions on the quotient space, trim against a fault network, and produce a three-dimensional model of a geological structure.

US Patent:

20190263661, Aug 29, 2019

Filed:

Jun 27, 2017

Appl. No.:

16/310533

Inventors:

Anima B. BOSE - Houston TX, US
Wei LI - Houston TX, US
- Houston TX, US

Assignee:

University of Houston System - Houston TX

International Classification:

C01B 25/42
C01G 19/02
H01M 8/1016

Abstract:

A method of restoring the proton conductivity of a sintered pyrophosphate membrane of intermediate temperature fuel cells (IT-FCs) by introducing phosphoric acid into the sintered SnPOmembrane to react with the degraded SnPOspecies and thus restore the membrane pyrophosphate and proton conductivity. Such cells operate with low external humidification, and the active area of the cells may be fabricated up to 100 cmin size.

US Patent:

20170239212, Aug 24, 2017

Filed:

Aug 10, 2015

Appl. No.:

15/503495

Inventors:

- Salt Lake City UT, US
Matthew B. KRAFT - Salt Lake City UT, US
Anh P. TRUONG - Burlingame CA, US
Carina C. SANCHEZ - Somerville MA, US
Wei LI - Salt Lake City UT, US
Jonathan A. COVEL - San Diego CA, US
Dennie WELCH - Lake Bluff IL, US
Yam POUDEL - Salt Lake City UT, US
Mark E. PETERSEN - Salt Lake City UT, US

International Classification:

A61K 31/365

Abstract:

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including the treatment or prevention of viral infection. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in a low number of steps and with a high degree of substitution and specificity.

US Patent:

20160215309, Jul 28, 2016

Filed:

Apr 11, 2016

Appl. No.:

15/095158

Inventors:

- Houston TX, US
Wei LI - Houston TX, US

International Classification:

C12P 7/64
C12N 9/04
C12N 9/16

Abstract:

The present disclosure relates to an engineered microbe capable of improved productivity of fatty acid or fatty acid derivative. An NAD-dependent 3-oxoacyl-ACP reductase or NAD-dependent 3-oxoacyl-CoA reductase replaces or supplements the native NADP-dependent 3-oxoacyl-ACP reductase so as to utilize the higher availability of NAD rather than NADP in the cell. Higher production, yield and titer of fatty acids are therefore obtained. Such microbes can be combined with other mutations to further improve yield of fatty acids or fatty acid derivatives.

Address:

1447 W Debenham Pl, West Valley, UT 84119

VIN:

4A3AL35T48E018934

Make:

MITSUBISHI

Model:

ECLIPSE SPYDER

Year:

2008

Address:

7767 Cambridge St, Houston, TX 77054

VIN:

2T1KR32E37C649591

Make:

TOYOTA

Model:

MATRIX

Year:

2007