Wei K Yan

US Patent:

8193322, Jun 5, 2012

Filed:

Oct 23, 2006

Appl. No.:

11/585505

Inventors:

Wei Yan - Sammamish WA, US
Michael Wittekind - Bainbridge Island WA, US
Carla Forte - Bainbridge Island WA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 16/46
C12P 21/08

US Classification:

53038822, 5303911

Abstract:

The present invention relates to monovalent antibody, methods of making thereof and therapeutic uses thereof. In particular, the present invention provides a heterodimeric polypeptide comprising an immunoglobulin heavy chain and a fusion protein comprising an immunoglobulin light chain and an Fc molecule.

US Patent:

8227251, Jul 24, 2012

Filed:

Apr 14, 2010

Appl. No.:

12/760500

Inventors:

Jeff Ranish - Seattle WA, US
Jie Luo - Seattle WA, US
Wei Yan - Edmonds WA, US

Assignee:

Institute for Systems Biology - Seattle WA

International Classification:

G01N 33/68

US Classification:

436 86, 436 56, 436 89, 436173, 250281, 250282

Abstract:

The present invention relates to methods for analyzing complex mixtures of proteins, both for identification and quantitation of proteins of interest, and in particular, methods of identification and quantitation of proteins present at low levels, using internal standard peptides isobarically tagged at the N and C termini.

US Patent:

8592562, Nov 26, 2013

Filed:

Jan 6, 2009

Appl. No.:

12/811207

Inventors:

Gunasekaran Kannan - Issaquah WA, US
Michael Wittekind - Bainbridge Island WA, US
Wei Yan - Sammamish WA, US
Martin Pentony - Seattle WA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 16/00
C07H 21/04
C12N 15/63
C12N 5/10

US Classification:

5303873

Abstract:

The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer. Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.

US Patent:

7267960, Sep 11, 2007

Filed:

Jul 23, 2004

Appl. No.:

10/898408

Inventors:

Laurent J. Galibert - Seattle WA, US
Wei Yan - Sammamish WA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

G01N 33/53
C07K 16/28
C07K 17/00

US Classification:

435 71, 53038824, 5303911

Abstract:

The invention pertains to agonists and antagonists of LDCAM and methods of treating disease and infection by administering one or more LDCAM antagonists or agonists. This abstract is provided for the sole purpose of enabling the reader to quickly ascertain the subject matter of the technical disclosure and is not intended to be used to interpret or limit the scope or meaning of the claims.

US Patent:

8043615, Oct 25, 2011

Filed:

Sep 7, 2007

Appl. No.:

11/852123

Inventors:

Laurent J. Galibert - Prevessin Moen, FR
Wei Yan - Sammamish WA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 39/395

US Classification:

4241301

Abstract:

The invention pertains to agonists and antagonists of LDCAM and methods of treating disease and infection by administering one or more LDCAM antagonists or agonists.

US Patent:

20050026255, Feb 3, 2005

Filed:

Aug 26, 2004

Appl. No.:

10/926083

Inventors:

John Morser - San Francisco CA, US
Qingyu Wu - El Sorbante CA, US
Wei Yan - Hercules CA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/64

US Classification:

435069100, 435226000, 435320100, 435325000, 536023200

Abstract:

The present invention relates to a corin polypeptide which contains one or more frizzled corin and possesses various activities, including, e.g., serin protease activity and a pro-ANF converting activity, LDLR, SRCR repeats, serine protease catalytic domains such as human and mouse corin. The invention further relates to methods of using such nucleic acids and polypeptides in therapeutics, diagnostics, and research. For example, the nucleic acids and polypeptides of corin can be utilized in methods to identify modulators of its activity, in animal models to mimic human disease, and to treat kidney, cardiovascular, and other conditions in which corin is involved.

US Patent:

20050282181, Dec 22, 2005

Filed:

Dec 21, 2004

Appl. No.:

11/019027

Inventors:

Wei Yan - Sammamish WA, US
Wenyan Shen - Thousand Oaks CA, US
Hongxing Zhou - Bellevue WA, US
Chen Zhou - Thousand Oaks CA, US
David Cosman - Bainbridge Island WA, US
Paul Carter - Mercer Island WA, US
Francis Martin - Newbury Park CA, US

International Classification:

C12Q001/68
G01N033/53
C07H021/04
C07K016/18

US Classification:

435006000, 435007100, 435320100, 435326000, 530387100, 536023530, 435069100

Abstract:

The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.

US Patent:

20140024111, Jan 23, 2014

Filed:

Sep 25, 2013

Appl. No.:

14/037040

Inventors:

Michael WITTEKIND - New Canaan CT, US
Wei YAN - Sammamish WA, US
Martin J. PENTONY - Seattle WA, US

Assignee:

AMGEN INC. - THOUSAND OAKS CA

International Classification:

C07K 16/00

US Classification:

435328

Abstract:

The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides.