Wei Zhang

US Patent:

D555885, Nov 27, 2007

Filed:

Nov 14, 2005

Appl. No.:

29/242717

Inventors:

Wei Zhang - City of Industry CA, US

International Classification:

0204

US Classification:

D 2954, D2960

US Patent:

7829063, Nov 9, 2010

Filed:

Apr 7, 2008

Appl. No.:

12/099135

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Los Angeles CA, US
Wei Zhang - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Canton MA, US
Peter J. H. Scott - Marina-del-Ray CA, US
Zhiyong Gao - Los Angeles CA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
C07D 343/00

US Classification:

424 111, 549 32

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

US Patent:

7844567, Nov 30, 2010

Filed:

Aug 13, 2007

Appl. No.:

11/837570

Inventors:

Xiaofei He - Burbank CA, US
Wei Vivian Zhang - Glendale CA, US

Assignee:

Yahoo! Inc. - Sunnyvale CA

International Classification:

G06F 17/00
G06N 7/00
G06N 7/08

US Classification:

706 59

Abstract:

Described are a system and method for selecting a training sample from a sample set. The method comprises determining proximities between all data samples in a set of the data samples, forming edges between the data samples as a function of the proximities, computing weights for the edges as a function of the proximities, selecting a plurality of the data samples as a function of the weights to form a subset of the data samples, and storing the subset of the data samples.

US Patent:

8158714, Apr 17, 2012

Filed:

Dec 23, 2008

Appl. No.:

12/342874

Inventors:

Ritesh Ravi Nair - Irvine CA, US
Tek Wayne Woo - Chandler AZ, US
Catherine A. Finegan - Warrington PA, US
Ozzie M. Pressley - Cheltenham PA, US
Wei Zhang - Maple Glen PA, US

Assignee:

Rohm and Haas Company - Philadelphia PA
Masco Corporation - Taylor MI

International Classification:

C08L 31/02

US Classification:

524556, 524497, 524560, 524547

Abstract:

Disclosed herein is a method that includes mixing opacifying agent particles with a thickening agent to form a first mixture; the mixing being conducted at a shear rate of about 10 to about 2,000 sec; the first mixture having a viscosity of greater than or equal to about 70 Krebs units; and mixing a polymer latex binder with the first mixture to form a coating composition; the polymer latex binder including a copolymer that comprises phosphorus containing repeat units and an acrylate polymer.

US Patent:

8318132, Nov 27, 2012

Filed:

Feb 17, 2009

Appl. No.:

12/372717

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Peter J. H. Scott - Marina-del-Rey CA, US
Kai Chen - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Eric Wang - San Diego CA, US
Anjana Sinha - San Diego CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 111, 424 189, 424 185, 424 181, 424 165, 424 91

Abstract:

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

US Patent:

8354092, Jan 15, 2013

Filed:

Aug 25, 2010

Appl. No.:

12/862955

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Rockville MD, US
Wei Zhang - Norwood MA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Mansfield MA, US
Peter J. H. Scott - Ypsilanti MI, US
Zhiyong Gao - Wynnewood PA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
C07D 249/00
C07D 343/00

US Classification:

424 153, 514359, 514449, 514461, 530330, 548255, 549429

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

US Patent:

8420052, Apr 16, 2013

Filed:

Jul 24, 2009

Appl. No.:

12/509259

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Kai Chen - Rockville MD, US
Anjana Sinha - San Diego CA, US
Eric Wang - San Diego CA, US
Gang Chen - Los Angeles CA, US
Peter J. H. Scott - Ypsilanti MI, US
Henry Clifton Padgett - Hermosa Beach CA, US
Qianwa Liang - Hacienda Heights CA, US
Zhiyong Gao - Wynnewood PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 189, 424 111, 424 165, 424 181, 424 185

Abstract:

Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.

US Patent:

8491869, Jul 23, 2013

Filed:

Mar 23, 2010

Appl. No.:

12/661777

Inventors:

Umesh B. Gangadharmath - Los Angeles CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
Peter J. H. Scott - Ypsilanti MI, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Anna Katrin Szardenings - Torrance CA, US
Anjana Sinha - San Diego CA, US
Gang Chen - Los Angeles CA, US
Eric Wang - San Diego CA, US
Chul Yu - Los Angeles CA, US
Changhui Liu - Los Angeles CA, US
Daniel Kurt Cashion - Manhattan Beach CA, US
Dhanalakshmi Kasi - Los Angeles CA, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 189, 424 111, 424 165, 424 181, 424 185

Abstract:

Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.