Wenhui W Li

Address:

22207 Yarrow Trl, Strongsville, OH 44149

VIN:

2FMDK49C88BB19727

Make:

FORD

Model:

EDGE

Year:

2008

US Patent:

20050282154, Dec 22, 2005

Filed:

Oct 5, 2004

Appl. No.:

10/957880

Inventors:

Michael Farzan - Cambridge MA, US
Wenhui Li - Boston MA, US
Michael Moore - Cambridge MA, US

International Classification:

C12Q001/70
C12N007/01
C12N015/86

US Classification:

435005000, 435235100, 435456000

Abstract:

The present invention is based upon the identification of human angiotensin-converting enzyme-2 (ACE-2) as a functional receptor for the SARS coronavirus. Transfection of cells with ACE-2 confers upon them the ability to support viral replication. In addition, assays performed using ACE-2 together with the S protein of the SARS virus or a fragment derived from the S protein can be used to identify inhibitors that block the interaction between virus and host cell.

US Patent:

20050113298, May 26, 2005

Filed:

Sep 13, 2004

Appl. No.:

10/939113

Inventors:

Michael Farzan - Cambridge MA, US
Wenhui Li - Boston MA, US

International Classification:

A61K038/17
C07H021/04
C07K014/705
C07K016/40

US Classification:

514012000, 530350000, 530388260, 435069100, 435320100, 435325000, 536023500

Abstract:

The present invention is directed to peptides that bind to the cellular receptors for the SARS S protein. The invention also includes polynucleotides coding for these peptides and methods in which they can be used to block the binding of the S protein to receptor. The peptides can also be detectably labeled and used in assays for identifying cells that have receptors for the S protein, in vaccines and for identifying other agents that inhibit receptor binding.