William L Bowers

US Patent:

20080193416, Aug 14, 2008

Filed:

Jun 5, 2006

Appl. No.:

11/916440

Inventors:

Howard J. Federoff - Bethesda MD, US
William J. Bowers - Webster NY, US

Assignee:

University of Rochester - Rochester NY

International Classification:

A61K 48/00
C12N 15/63
C07H 21/04
C12N 5/06
C12N 15/11
C12Q 1/48
C12Q 1/37
C12Q 1/26
C12Q 1/02
C40B 40/02
A61K 31/7052
C12N 7/00

US Classification:

424 932, 4353201, 536 231, 514 44, 4352351, 435325, 506 14, 435455, 435461, 435 29, 435 15, 435 25, 435 23

Abstract:

This disclosure features vectors, targeting vectors, modified artificial chromosomes, herpes virus particles in which such chromosomes are packaged, and methods of using the herpes virus particles to identify therapeutic agents and targets for therapeutic intervention.

US Patent:

20080226601, Sep 18, 2008

Filed:

Jun 5, 2006

Appl. No.:

11/916434

Inventors:

Howard J. Federoff - Bethesda MD, US
William J. Bowers - Webster NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 48/00
C12Q 1/70

US Classification:

424 932, 435 5

Abstract:

Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.

US Patent:

20110039916, Feb 17, 2011

Filed:

Jun 6, 2007

Appl. No.:

12/303481

Inventors:

Howard J. Federoff - Bethesda MD, US
William J. Bowers - Webster NY, US

Assignee:

UNIVERSITY OF ROCHESTER - Rochester NY

International Classification:

A61K 31/7088
C12P 19/34
C12N 15/64
C12N 5/10
C07H 21/04
C12N 7/00
A61P 27/16

US Classification:

514 44 R, 435 911, 435 914, 435325, 536 231, 4352351

Abstract:

The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.

US Patent:

40149013, Mar 29, 1977

Filed:

Jul 2, 1975

Appl. No.:

5/592697

Inventors:

William S. Bowers - Bowie MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C07D31710

US Classification:

2603409

Abstract:

Ethers of open chain terpenoid compounds and their monoepoxides were synthesized and found to mimic the juvenile hormones of insects and to be extremely effective as insect control agents.

US Patent:

39609022, Jun 1, 1976

Filed:

Jul 2, 1975

Appl. No.:

5/592688

Inventors:

William S. Bowers - Bowie MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C07D30322

US Classification:

260348R

Abstract:

Ethers of open chain terpenoid compounds and their monoepoxides were synthesized and found to mimic the juvenile hormones of insects and to be extremely effective as insect control agents.

US Patent:

39706885, Jul 20, 1976

Filed:

Jul 2, 1975

Appl. No.:

5/592682

Inventors:

William S. Bowers - Bowie MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C07C 5922

US Classification:

260484R

Abstract:

Ethers of open chain terpenoid compounds and their monoepoxides were synthesized and found to mimic the juvenile hormones of insects and to be extremely effective as insect control agents.

US Patent:

39592642, May 25, 1976

Filed:

Jul 2, 1975

Appl. No.:

5/592696

Inventors:

William S. Bowers - Bowie MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C07D30304
C07D31712

US Classification:

260240R

Abstract:

Ethers of open chain terpenoid compounds and their monoepoxides were synthesized and found to mimic the juvenile hormones of insects and to be extremely effective as insect control agents.

US Patent:

39364755, Feb 3, 1976

Filed:

Jul 2, 1975

Appl. No.:

5/592689

Inventors:

William S. Bowers - Bowie MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

C07D30328

US Classification:

260348R

Abstract:

Ethers of open chain terpenoid compounds and their monoepoxides were synthesized and found to mimic the juvenile hormones of insects and to be extremely effective as insect control agents.