William Hogan Bryan

US Patent:

6436346, Aug 20, 2002

Filed:

Sep 14, 1999

Appl. No.:

09/395630

Inventors:

Mitchel J. Doktycz - Knoxville TN
Stephen F. Smith - Loudon TN
Patrick I. Oden - Plano TX
William L. Bryan - Knoxville TN
James A. Moore - Powell TN
Thomas G. Thundat - Knoxville TN
Robert J. Warmack - Knoxville TN

Assignee:

U T Battelle, LLC - Oak Ridge TN

International Classification:

G01N 2520

US Classification:

422 51, 436147, 73 2406, 73 2501, 374 45, 374 12, 438 54

Abstract:

A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

US Patent:

6569687, May 27, 2003

Filed:

Dec 15, 2000

Appl. No.:

09/738821

Inventors:

Mitchel J. Doktycz - Knoxville TN
William Louis Bryan - Knoxville TN
Reid Kress - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G01N 110

US Classification:

436180, 436174, 422100, 7386417, 7386332, 73864, 7386401, 7386402, 7386411

Abstract:

A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

US Patent:

6627157, Sep 30, 2003

Filed:

Mar 4, 1999

Appl. No.:

09/262455

Inventors:

Mitchel J. Doktycz - Knoxville TN
William Louis Bryan - Knoxville TN
Reid Kress - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

B01L 302

US Classification:

422100, 436180, 73864, 7386401, 7386411, 7386402, 7386332, 7386417

Abstract:

A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

US Patent:

7525431, Apr 28, 2009

Filed:

May 6, 2004

Appl. No.:

10/840553

Inventors:

Mark A. Buckner - Oak Ridge TN, US
Gregory R. Hanson - Clinton TN, US
William L. Bryan - Knoxville TN, US

Assignee:

UT-Battelle LLC - Oak Ridge TN

International Classification:

G08B 13/14

US Classification:

3405721, 34053929

Abstract:

Methods and apparatus are described for space charge dosimeters for extremely low power measurements of radiation in shipping containers. A method includes insitu polling a suite of passive integrating ionizing radiation sensors including reading-out dosimetric data from a first passive integrating ionizing radiation sensor and a second passive integrating ionizing radiation sensor, where the first passive integrating ionizing radiation sensor and the second passive integrating ionizing radiation sensor remain situated where the dosimetric data was integrated while reading-out. Another method includes arranging a plurality of ionizing radiation sensors in a spatially dispersed array; determining a relative position of each of the plurality of ionizing radiation sensors to define a volume of interest; collecting ionizing radiation data from at least a subset of the plurality of ionizing radiation sensors; and triggering an alarm condition when a dose level of an ionizing radiation source is calculated to exceed a threshold.

US Patent:

7932828, Apr 26, 2011

Filed:

Mar 18, 2009

Appl. No.:

12/406725

Inventors:

Mark A. Buckner - Oak Ridge TN, US
Gregory R. Hanson - Clinton TN, US
William L. Bryan - Knoxville TN, US

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G08B 13/14
G01T 1/24
H01L 23/62

US Classification:

3405721, 25037001, 25037014, 25037015, 257355, 257678

Abstract:

Methods and apparatus are described for space charge dosimeters for extremely low power measurements of radiation in shipping containers. A method includes in situ polling a suite of passive integrating ionizing radiation sensors including reading-out dosimetric data from a first passive integrating ionizing radiation sensor and a second passive integrating ionizing radiation sensor, where the first passive integrating ionizing radiation sensor and the second passive integrating ionizing radiation sensor remain situated where the dosimetric data was integrated while reading-out. Another method includes arranging a plurality of ionizing radiation sensors in a spatially dispersed array; determining a relative position of each of the plurality of ionizing radiation sensors to define a volume of interest; collecting ionizing radiation data from at least a subset of the plurality of ionizing radiation sensors; and triggering an alarm condition when a dose level of an ionizing radiation source is calculated to exceed a threshold.

US Patent:

7936270, May 3, 2011

Filed:

Mar 18, 2009

Appl. No.:

12/406680

Inventors:

Mark A. Buckner - Oak Ridge TN, US
Gregory R. Hanson - Clinton TN, US
William L. Bryan - Knoxville TN, US

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G08B 13/14
H01L 29/76
H01L 23/28
G01T 1/24

US Classification:

3405721, 25037001, 25037014, 25037015, 257701, 257787, 257213

Abstract:

Methods and apparatus are described for space charge dosimeters for extremely low power measurements of radiation in shipping containers. A method includes insitu polling a suite of passive integrating ionizing radiation sensors including reading-out dosimetric data from a first passive integrating ionizing radiation sensor and a second passive integrating ionizing radiation sensor, where the first passive integrating ionizing radiation sensor and the second passive integrating ionizing radiation sensor remain situated where the dosimetric data was integrated while reading-out. Another method includes arranging a plurality of ionizing radiation sensors in a spatially dispersed array; determining a relative position of each of the plurality of ionizing radiation sensors to define a volume of interest; collecting ionizing radiation data from at least a subset of the plurality of ionizing radiation sensors; and triggering an alarm condition when a dose level of an ionizing radiation source is calculated to exceed a threshold.

US Patent:

61677485, Jan 2, 2001

Filed:

Aug 31, 1998

Appl. No.:

9/144309

Inventors:

Charles L. Britton - Alcoa TN
Robert J. Warmack - Knoxville TN
William L. Bryan - Knoxville TN
Robert L. Jones - Decatur TN
Patrick Ian Oden - Knoxville TN
Thomas Thundat - Knoxville TN

Assignee:

Lockheed Martin Energy Research Corporation - Oak Ridge TN
University of Tennessee Research Corporation - Knoxville TN

International Classification:

G01B 716
G01M 304
G01N 1910
G01N 2700
G01N 33543

US Classification:

73 2406

Abstract:

An improved multi-element apparatus for detecting the presence of at least one chemical, biological or physical component in a monitored area comprising an array or single set of the following elements: a capacitive transducer having at least one cantilever spring element secured thereto, the cantilever element having an area thereof coated with a chemical having an affinity for the component to be detected; a pick-up plate positioned adjacent to the cantilever element at a distance such that a capacitance between the cantilever element and the pick-up plate changes as the distance between the cantilever element and the pick-up plate varies, the change in capacitance being a measurable variation; a detection means for measuring the measurable variation in the capacitance between the cantilever element and the pick-up plate that forms a measurement channel signal; and at least one feedback cantilever spring element positioned apart from the coated cantilever element, the cantilever element substantially unaffected by the component being monitored and providing a reference channel signal to the detection means that achieves a common mode cancellation between the measurement channel signal and reference channel signal.

US Patent:

54211077, Jun 6, 1995

Filed:

Dec 13, 1993

Appl. No.:

8/165987

Inventors:

William N. Bryan - Allen TX

International Classification:

A43B 330

US Classification:

36139

Abstract:

A child's shoe of elastomeric, deformable sole construction has a cavity located in a middle portion of the sole, between the upper and lower surfaces and connected to the side of the sole by a passageway. In use, volumetric changes of the cavity create an air flow through the passageway and a whistle, with the whistle selectively positioned to make noise or not make noise.