William A Carpenter

US Patent:

20050227233, Oct 13, 2005

Filed:

Mar 19, 2003

Appl. No.:

10/507858

Inventors:

Francis Buxton - Winchester MA, US
William Carpenter - Columbia MD, US
Rosalinda Roberts - Columbia MD, US
Carol Tamminga - Dallas TX, US

International Classification:

C12Q001/68
A61K048/00

US Classification:

435006000, 514044000

Abstract:

The gene encoding decidual protein induced by progesterone (DEPP), the gene encoding adrenomedullin and the gene encoding cold shock domain protein A (csdA), are upregulated in the anterior cingulate of schizophrenic patients as compared to normal patients. Methods of screening, diagnosing and treating schizophrenia based on these genes are provided. Transgenic nonhuman animals having increased copy number or increased expression levels of these genes are also provided. The transgenic nonhuman animals are used in methods of screening for potential therapeutic agents.

US Patent:

20070015152, Jan 18, 2007

Filed:

Dec 11, 2003

Appl. No.:

10/538339

Inventors:

Francis Buxton - Winchester MA, US
William Carpenter - Columbia MD, US
Rosalinda Roberts - Columbia MD, US
Carol Tamminga - Dallas TX, US

Assignee:

Novartis AG - Basel
University of Maryland - Baltimore MD

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The genes encoding SCYA2, GADD45B, S100A8, CDKN1A, IL1RL1, TGM2, MAFF, SERPINA3, GRO1, CD14, KIAA1075, CHI3L1, SERPINH1, MT1X, KIAA0620, TIMP1, NUMA1, DDIT3 and TOB2, are upregulated in the anterior cingulate of schizophrenic patients compared to normal patients and as such are useful drug targets for schizophrenia. Methods of screening, diagnosing and treating schizophrenia based on these genes are provided. Transgenic nonhuman animals having increased copy number or increased expression levels of these genes are also provided. The transgenic nonhuman animals are used in methods for screening for potential therapeutic agents.

US Patent:

20190283030, Sep 19, 2019

Filed:

Jul 19, 2017

Appl. No.:

16/319296

Inventors:

- Tarrytown NY, US
Dimitri Shishkin - Whippany NJ, US
Shriram Patel - Saddle Brook NJ, US
Beri Cohen - Hartsdale NY, US
William Carpenter - Stony Point NY, US

Assignee:

Siemens Healthcare Diagnostics Inc. - Tarrytown NY

International Classification:

B01L 7/00
G01N 35/00

Abstract:

An environmental control system for use in a clinical analyzer module includes an upper deck environmental subsystem comprising a far field sensor, one or more heaters, one or more spine cooling fans, and one or more in-line fluid heat exchangers. The far field sensor is configured to acquire measurements of ambient temperature in the upper deck environmental subsystem. The heaters are configured to generate hot airflow based on the measurements of ambient temperature from the far field sensor. The spine cooling fans are configured to operate in a manner that mixes the hot airflow from the heaters with cool airflow based on the measurements of ambient temperature from the far field sensor. The in-line fluid heat exchangers are configured to heat fluids used in reactions performed on the clinical analyzer module to a constant temperature.