William Chiang

US Patent:

20040072282, Apr 15, 2004

Filed:

Jun 23, 2003

Appl. No.:

10/602265

Inventors:

Frank Guarnieri - Princeton NJ, US
John Kulp - Princeton NJ, US
William Chiang - Princeton NJ, US

Assignee:

Sarnoff Corporation

International Classification:

C12P021/06
C07K014/47

US Classification:

435/068100, 530/403000

Abstract:

Methods for chemical ligation and synthesis of peptides and polypeptides including membrane polypeptides and hydrophobic peptides and polypeptides or membrane polypeptide domains in a multiphase solvent mixture comprising at least two component solvents; compositions produced using these methods and assays performed using these compositions.

US Patent:

59851198, Nov 16, 1999

Filed:

May 10, 1996

Appl. No.:

8/645966

Inventors:

Peter John Zanzucchi - Lawrenceville NJ
Charlotte Anna Burton - Brick NJ
Sterling Edward McBride - Lawrenceville NJ
Satyam Choudary Cherukuri - Cranbury NJ
William Chiang - Monmouth Junction NJ
Aaron W. Levine - Mercer NJ
Richard Morgan Moroney - Princeton NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726

US Classification:

204450

Abstract:

The invention provides methods of performing a synthetic process in a liquid distribution system having reaction cells, by pumping at least one reagent into a reaction cell.

US Patent:

59618000, Oct 5, 1999

Filed:

May 8, 1997

Appl. No.:

8/848413

Inventors:

Sterling Eduard McBride - Lawrenceville NJ
William Chiang - Monmouth Junction NJ
Paul James Heaney - Skillman NJ
Satyam Choudary Cherukuri - Cranbury NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726

US Classification:

204450

Abstract:

Provided is an electrode-based pump having source of a pumped fluid, a conduit channel of capillary dimensions connected via a first end to the pumped fluid source and having an outlet at a second end, a piston channel with a first end that intersects the conduit channel, wherein the piston channel allows for periodic inward and outward movement of a piston plug of liquid, two or more electrodes inserted into the piston channel which define an electrode-based pump, wherein the electrode-based pump can be operated to move the piston plug of liquid inward and outward.

US Patent:

58463968, Dec 8, 1998

Filed:

Nov 9, 1995

Appl. No.:

8/556036

Inventors:

Peter John Zanzucchi - West Windsor Township, Mercer County NJ
Satyam Choudary Cherukuri - Cranbury NJ
Sterling Edward McBride - Lawrence Township, Mercer County NJ
Robert R. Demers - Cranbury NJ
Aaron W. Levine - Lawrenceville NJ
Barry Jay Thaler - Lawrenceville NJ
Robert Leon Quinn - Trenton NJ
Paul Leonard Braun - Highland Park NJ
William Chiang - Monmouth Junction NJ
Zhonghui Hugh Fan - Plainsboro NJ
Steven A. Lipp - Cranbury NJ
James R. Matey - Mercerville NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726
G01N 2100
B01L 1100

US Classification:

204601

Abstract:

The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The distribution system can comprise an alpha reservoir and a beta reservoir, a first set of parallel and adjacent first and second feeder channels and a second set of parallel and adjacent third and fourth feeder channels which are offset from the first and second feeder channels, wherein (a) the first and third feeder channels are connected to the alpha reservoir via a first connector channel that is situated above or below the second and fourth feeder channels and are independent of the beta reservoir and (b) the second and fourth feeder channels are connected to the beta reservoir via a second connector channel that is situated above or below the first and third feeder channels and are independent of the alpha reservoir. The distribution system is preferably a microscale distribution system. Various particular mechanisms for controlling flow into a liquid distribution system are described.

US Patent:

58581936, Jan 12, 1999

Filed:

Nov 9, 1995

Appl. No.:

8/556423

Inventors:

Peter John Zanzucchi - Lawrenceville NJ
Charlotte Anna Burton - Brick NJ
Sterling Edward McBride - Lawrenceville NJ
Robert Richard Demers - Cranbury NJ
William Chiang - Monmouth Junction NJ
Richard Morgan Moroney - Plainsboro NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726

US Classification:

204601

Abstract:

The invention provides electrode-based pumps and methods of operating such pumps. In one embodiment, the invention provides an electrode-based pump situated in a fluid channel comprising a first electrode and a second electrode, wherein the first and second electrodes have a diameter from about 25 microns to about 100 microns and are spaced from about 100 microns to about 2,500 microns apart. In another embodiment, the invention provides an electrode-based pump comprising a first electrode, second electrode and third electrode.

US Patent:

62598465, Jul 10, 2001

Filed:

Oct 15, 1999

Appl. No.:

9/419374

Inventors:

William Ronald Roach - Rocky Hill NJ
Bawa Singh - Voorhees NJ
William Chiang - Monmouth Junction NJ
Zilan Shen - Wait Windsor NJ
Vipulkumar K. Patel - South Brunswick NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G02B 602
G02B 616

US Classification:

385123

Abstract:

A display as for images and/or information comprises a plurality of light-emitting fibers disposed in side-by-side arrangement to define a viewing surface. Each light-emitting fiber includes a plurality of light-emitting elements disposed along its length, each having two electrodes between which are applied electrical signals to cause the light-emitting element to emit light to display a pixel or sub-pixel of the image and/or information. The light-emitting fiber includes an electrical conductor disposed along its length to serve as a first electrode, a layer of light-emissive material disposed thereon, and a plurality of electrical contacts disposed on the light-emissive material to serve as the second electrodes of the light-emitting elements. Preferably, the conductors, light-emissive layer and plurality of electrical contacts are formed in a continuous process wherein a transparent fiber passes through a plurality of processing chambers for receiving the electrical conductor, the light-emissive layer and the plurality of electrical contacts thereon.

US Patent:

20200255552, Aug 13, 2020

Filed:

Apr 27, 2020

Appl. No.:

16/859001

Inventors:

- Basel, CH
William Chiang - Pennington NJ, US
Frank Kerrigan - Wadebridge, GB
Stuart Green - Camelford, GB
Craig Robson - Camelford, GB
Howard Easterfield - Bude, GB

International Classification:

C08F 8/34
G01N 27/327
C07D 417/14
C08G 73/02
C07D 279/20
A61K 49/00
C08G 75/24
C12Q 1/00
C08G 59/40
C08F 8/30
C07D 279/08

Abstract:

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

US Patent:

20180194877, Jul 12, 2018

Filed:

Mar 8, 2018

Appl. No.:

15/915184

Inventors:

- Basel, CH
William Chiang - Pennington NJ, US
Frank Kerrigan - Wadebridge, GB
Stuart Green - Camelford, GB
Craig Robson - Camelford, GB
Howard Easterfield - Bude, GB

International Classification:

C08F 8/34
G01N 27/327
C07D 417/14
C08G 73/02
C07D 279/20
A61K 49/00
C07D 279/08
C12Q 1/00
C08G 59/40
C08F 8/30
C08G 75/24

Abstract:

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.