William I Chiang

US Patent:

7415361, Aug 19, 2008

Filed:

Aug 18, 2004

Appl. No.:

10/920234

Inventors:

Stephan Brunner - Préverenges, CH
David Mosenkis - Philadelphia PA, US
Frank P. Hollinger - Wayne PA, US
William Chiang - Pennington NJ, US

Assignee:

Locus Pharmaceuticals, Inc. - Blue Bell PA

International Classification:

G06F 17/00
G06F 17/30

US Classification:

702 27, 702 19

Abstract:

A method implemented in the form of a computer simulation code for evaluating the free energy of binding between polypeptide amino acid residues and one or more molecular fragment types is presented. The basis of the method is a novel weighted Metropolis Monte Carlo approach for sampling the grand canonical ensemble. By making use of the properties of the grand canonical ensemble, the affinity of fragments for binding in the vicinity of each protein residue can be efficiently computed. The binding volume associated to each fragment-residue pair is estimated on the basis of a simple proximity criteria, and a useful affinity mapping of the protein surface can be obtained in this way. The analysis of such data for various fragment types provides valuable information to help identify protein binding sites, as well as to identify key fragments used for building potential drug leads.

US Patent:

8283347, Oct 9, 2012

Filed:

May 28, 2010

Appl. No.:

12/790165

Inventors:

Jiangfeng Fei - White Plains NY, US
William Chiang - Pennington NJ, US
Frank Kerrigan - Wadebridge, GB
Stuart Green - Camelford, GB

Assignee:

Bayer HealthCare LLC - Tarrytown NY

International Classification:

C07D 279/18
A61K 31/5415

US Classification:

5142262, 544 37

Abstract:

A non-leaching mediator may include a compound having the general formula (I):.

US Patent:

20040072282, Apr 15, 2004

Filed:

Jun 23, 2003

Appl. No.:

10/602265

Inventors:

Frank Guarnieri - Princeton NJ, US
John Kulp - Princeton NJ, US
William Chiang - Princeton NJ, US

Assignee:

Sarnoff Corporation

International Classification:

C12P021/06
C07K014/47

US Classification:

435/068100, 530/403000

Abstract:

Methods for chemical ligation and synthesis of peptides and polypeptides including membrane polypeptides and hydrophobic peptides and polypeptides or membrane polypeptide domains in a multiphase solvent mixture comprising at least two component solvents; compositions produced using these methods and assays performed using these compositions.

US Patent:

20050123993, Jun 9, 2005

Filed:

Dec 9, 2003

Appl. No.:

10/730267

Inventors:

Stephan Brunner - Preverenges, CH
David Mosenkis - Philadelphia PA, US
Frank Hollinger - Wayne PA, US
William Chiang - Pennington NJ, US

International Classification:

G01N033/53
G06F019/00
G01N033/48
G01N033/50

US Classification:

435007100, 702019000

Abstract:

Methods and systems for determining the affinity between polypeptide amino acid residues and one or more molecular fragments, and for using the affinity values to aid in drug design including a computer simulation which calculates the interaction energy between a polypeptide and at least one molecular fragment. An affinity value is then assigned to at least one fragment and residue pair if the fragment is in the vicinity of the residue. Affinity values are used to rank fragments, build ligands and determine binding sites.

US Patent:

20070005258, Jan 4, 2007

Filed:

Jun 7, 2005

Appl. No.:

11/146417

Inventors:

Frank Guarnieri - Brooklyn NY, US
Frank Hollinger - Wayne PA, US
Stephan Brunner - Preverenges, CH
William Chiang - Pennington NJ, US
Matthew Clark - Wayne PA, US
George Talbot - Philadelphia PA, US
Jason Ferrara - Yardley PA, US

International Classification:

G06F 19/00

US Classification:

702019000

Abstract:

Methods and systems of analyzing positions and orientations of molecular fragments to generate macromolecular binding ligands, including analyzing the positions and orientations of molecular fragments in relation to other molecular fragments to bond the molecular fragments to form ligands.

US Patent:

20110294959, Dec 1, 2011

Filed:

May 26, 2011

Appl. No.:

13/116427

Inventors:

Jiangfeng Fei - Sleepy Hollow NY, US
William Chiang - Pennington NJ, US
Frank Kerrigan - Wadebridge, GB
Stuart Green - Camelford, GB
Craig Robson - Camelford, GB
Howard Easterfield - Bude, GB

Assignee:

BAYER HEALTHCARE LLC - Tarrytown NY

International Classification:

C08F 8/36
C08F 34/00
C08G 75/24
C08F 22/06

US Classification:

5253267, 5253275, 528377, 525349

Abstract:

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

US Patent:

59851198, Nov 16, 1999

Filed:

May 10, 1996

Appl. No.:

8/645966

Inventors:

Peter John Zanzucchi - Lawrenceville NJ
Charlotte Anna Burton - Brick NJ
Sterling Edward McBride - Lawrenceville NJ
Satyam Choudary Cherukuri - Cranbury NJ
William Chiang - Monmouth Junction NJ
Aaron W. Levine - Mercer NJ
Richard Morgan Moroney - Princeton NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726

US Classification:

204450

Abstract:

The invention provides methods of performing a synthetic process in a liquid distribution system having reaction cells, by pumping at least one reagent into a reaction cell.

US Patent:

6228228, May 8, 2001

Filed:

Oct 15, 1999

Appl. No.:

9/418774

Inventors:

Bawa Singh - Voorhees NJ
William Ronald Roach - Rocky Hill NJ
William Chiang - Monmouth Junction NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

H05B 3300
H01L 5120

US Classification:

2041921

Abstract:

A display as for images and/or information comprises a plurality of light-emitting fibers disposed in side-by-side arrangement to define a viewing surface. Each light-emitting fiber includes a plurality of light-emitting elements disposed along its length, each having two electrodes between which are applied electrical signals to cause the light-emitting element to emit light to display a pixel or sub-pixel of the image and/or information. The light-emitting fiber includes an electrical conductor disposed along its length to serve as a first electrode, a layer of light-emissive material disposed thereon, and a plurality of electrical contacts disposed on the light-emissive material to serve as the second electrodes of the light-emitting elements, and are formed in a continuous process wherein a transparent fiber passes through a plurality of processing chambers for receiving the electrical conductor, the light-emissive layer and the plurality of electrical contacts thereon. The method of making a light-emitting fiber comprises providing a length of a fiber, forming a first electrode along the fiber, depositing a light-emitting material along the fiber in electrical contact with the first electrode, and forming a plurality of second electrodes along the fiber in electrical contact with the light-emitting material.