William Chiang

US Patent:

8283347, Oct 9, 2012

Filed:

May 28, 2010

Appl. No.:

12/790165

Inventors:

Jiangfeng Fei - White Plains NY, US
William Chiang - Pennington NJ, US
Frank Kerrigan - Wadebridge, GB
Stuart Green - Camelford, GB

Assignee:

Bayer HealthCare LLC - Tarrytown NY

International Classification:

C07D 279/18
A61K 31/5415

US Classification:

5142262, 544 37

Abstract:

A non-leaching mediator may include a compound having the general formula (I):.

US Patent:

20070005258, Jan 4, 2007

Filed:

Jun 7, 2005

Appl. No.:

11/146417

Inventors:

Frank Guarnieri - Brooklyn NY, US
Frank Hollinger - Wayne PA, US
Stephan Brunner - Preverenges, CH
William Chiang - Pennington NJ, US
Matthew Clark - Wayne PA, US
George Talbot - Philadelphia PA, US
Jason Ferrara - Yardley PA, US

International Classification:

G06F 19/00

US Classification:

702019000

Abstract:

Methods and systems of analyzing positions and orientations of molecular fragments to generate macromolecular binding ligands, including analyzing the positions and orientations of molecular fragments in relation to other molecular fragments to bond the molecular fragments to form ligands.

US Patent:

20110294959, Dec 1, 2011

Filed:

May 26, 2011

Appl. No.:

13/116427

Inventors:

Jiangfeng Fei - Sleepy Hollow NY, US
William Chiang - Pennington NJ, US
Frank Kerrigan - Wadebridge, GB
Stuart Green - Camelford, GB
Craig Robson - Camelford, GB
Howard Easterfield - Bude, GB

Assignee:

BAYER HEALTHCARE LLC - Tarrytown NY

International Classification:

C08F 8/36
C08F 34/00
C08G 75/24
C08F 22/06

US Classification:

5253267, 5253275, 528377, 525349

Abstract:

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

US Patent:

63261499, Dec 4, 2001

Filed:

Nov 2, 1999

Appl. No.:

9/432745

Inventors:

Zyi Gerald Loewy - Fair Lawn NJ
William Chiang - Monmouth Junction NJ
Hoi Cheong Sun - Dayton NJ
Bryan Lloyd Bentz - Princeton NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

C12Q 168
B05D 104
B05D 112
H05C 100

US Classification:

435 6

Abstract:

Provided is a method of fabricating a substrate having on a surface thereof two or more spatially-resolved regions, each with a defined amount or concentration of one of one or more chemical components, the method comprising: associating a chemical component with particles of 1. mu. m to 500. mu. m diameter; electrostatically depositing the particles on the appropriate regions; and if a said spatially-resolved region is to receive a second chemical component, repeating steps (a) and (b) for that chemical component and the appropriate regions.

US Patent:

58463968, Dec 8, 1998

Filed:

Nov 9, 1995

Appl. No.:

8/556036

Inventors:

Peter John Zanzucchi - West Windsor Township, Mercer County NJ
Satyam Choudary Cherukuri - Cranbury NJ
Sterling Edward McBride - Lawrence Township, Mercer County NJ
Robert R. Demers - Cranbury NJ
Aaron W. Levine - Lawrenceville NJ
Barry Jay Thaler - Lawrenceville NJ
Robert Leon Quinn - Trenton NJ
Paul Leonard Braun - Highland Park NJ
William Chiang - Monmouth Junction NJ
Zhonghui Hugh Fan - Plainsboro NJ
Steven A. Lipp - Cranbury NJ
James R. Matey - Mercerville NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726
G01N 2100
B01L 1100

US Classification:

204601

Abstract:

The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The distribution system can comprise an alpha reservoir and a beta reservoir, a first set of parallel and adjacent first and second feeder channels and a second set of parallel and adjacent third and fourth feeder channels which are offset from the first and second feeder channels, wherein (a) the first and third feeder channels are connected to the alpha reservoir via a first connector channel that is situated above or below the second and fourth feeder channels and are independent of the beta reservoir and (b) the second and fourth feeder channels are connected to the beta reservoir via a second connector channel that is situated above or below the first and third feeder channels and are independent of the alpha reservoir. The distribution system is preferably a microscale distribution system. Various particular mechanisms for controlling flow into a liquid distribution system are described.