William H Ewing

US Patent:

6602864, Aug 5, 2003

Filed:

Jun 3, 1998

Appl. No.:

09/090492

Inventors:

Yong Mi Choi-Sledeski - Collegeville PA
Henry W. Pauls - Collegeville PA
Jeffrey N. Barton - Philadelphia PA
William R. Ewing - Downingtown PA
Daniel M. Green - Ambler PA
Michael R. Becker - Norristown PA
Yong Gong - Norristown PA

Assignee:

Aventis Pharma Deutschland GmbH - Frankfurt

International Classification:

A61K 3155

US Classification:

51421002, 51421004, 51421009, 51421016, 51421021, 51421207, 51421208, 51421301, 51421707, 514307, 514309, 514310, 540203, 540354, 540356, 540363, 540364, 540523, 540524, 540593, 540594, 540595, 540597, 546139, 546141, 546142, 546143, 546145, 546146

Abstract:

The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

US Patent:

20020013310, Jan 31, 2002

Filed:

Jul 30, 2001

Appl. No.:

09/918039

Inventors:

Yong Choi-Sledeski - Collegeville PA, US
Heinz Pauls - Collegeville PA, US
Jeffrey Barton - Philadelphia PA, US
William Ewing - Downingtown PA, US
Daniel Green - Ambler, PA
Michael Becker - Norristown PA, US
Yong Gong - Norristown PA, US
Julian Levell - Royersford PA, US

International Classification:

A61K031/55
A61K031/445
A61K031/40
C07D223/12

US Classification:

514/217110, 514/426000, 514/329000, 540/605000, 546/223000, 548/557000

Abstract:

The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, for treating a patient suffering from, or subject to, a physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

US Patent:

62812270, Aug 28, 2001

Filed:

Dec 2, 1999

Appl. No.:

9/453307

Inventors:

Yong Mi Choi-Sledeski - Collegeville PA
Heinz W. Pauls - Collegeville PA
Jeffrey N. Barton - Philadelphia PA
William R. Ewing - Downingtown PA
Daniel M. Green - Ambler PA
Michael R. Becker - Norristown PA
Yong Gong - Norristown PA
Julian Levell - Royersford PA

Assignee:

Aventis Pharma Deutschland GmbH - Frankfurt

International Classification:

A61K 3147
A61K 3155
C07D20508
C07D23900
C07D21700

US Classification:

514307

Abstract:

The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, for treating a patient suffering from, or subject to, a physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

US Patent:

57313156, Mar 24, 1998

Filed:

Dec 6, 1996

Appl. No.:

8/761414

Inventors:

William R. Ewing - Downingtown PA
Michael R. Becker - Norristown PA
Yong Mi Choi-Sledeski - Collegeville PA
Heinz W. Pauls - Collegeville PA
Daniel G. McGarry - King of Prussia PA
Roderick S. Davis - West Chester PA
Alfred P. Spada - Lansdale PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

C07D40102
A61K 3140
A61K 31435

US Classification:

514269

Abstract:

The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

US Patent:

52595544, Nov 9, 1993

Filed:

May 15, 1992

Appl. No.:

7/883543

Inventors:

William A. Ewing - Bethel CT
Richard L. Martin - Southbury CT

Assignee:

Memry Corp. - Brookfield CT

International Classification:

G05D 2302

US Classification:

236 87

Abstract:

A shape memory effect actuated diaphragmatic anti-scald valve, including a valve housing having a fluid flow path therethrough and including a pilot chamber. There is a first valve seat within the housing and a second valve seat within the housing and downstream from said first valve seat. A pilot valve is located within the chamber of the valve housing for preventing fluid flow through the chamber in which the pilot valve element is located when the SME valve is in its normal flow position and a first valve element is retained seated on the first valve seat by the pilot valve. There are means for controlling the open and closed positions of the pilot valve depending upon the temperature of the fluid flowing through the SME valve. A diaphragm defines a second valve element for the second valve seat and located in the main path of flow for the SME valve and being in an open position when fluid is flowing through the normal flow path and the fluid is directed at the bottom thereof for holding it off the second valve seat the second valve element in its first position opens a port which allows water pressure on the top side of the center of the diaphragm urging it to close against the second valve seat and in its second position in which the second valve element is open and the diaphragm is moved to its open position unseated from the second valve seat to permit normal water flow.

US Patent:

60340932, Mar 7, 2000

Filed:

Aug 6, 1998

Appl. No.:

9/130336

Inventors:

William R. Ewing - Downingtown PA
Michael R. Becker - Norristown PA
Yong Mi Choi-Sledeski - Collegeville PA
Heinz W. Pauls - Collegeville PA
Daniel G. McGarry - King of Prussia PA
Roderick S. Davis - West Chester PA
Alfred P. Spada - Lansdale PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

C07D40102
A61K 3140
A61K 31435

US Classification:

514301

Abstract:

The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

US Patent:

59589183, Sep 28, 1999

Filed:

Nov 21, 1997

Appl. No.:

8/976034

Inventors:

William R. Ewing - Downingtown PA
Michael R. Becker - Norristown PA
Henry W. Pauls - Collegeville PA
Daniel L. Cheney - Collegeville PA
Jonathan Stephen Mason - Phoenixville PA
Alfred P. Spada - Lansdale PA
Yong Mi Choi-Sledeski - Collegeville PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc.

International Classification:

C07D40102
A61K 3140
A61K 31435

US Classification:

514212

Abstract:

The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

US Patent:

56123531, Mar 18, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/481024

Inventors:

William R. Ewing - King of Prussia PA
Michael R. Becker - Norristown PA
Henry W. Pauls - Collegeville PA
Daniel L. Cheney - West Chester PA
Jonathan S. Mason - Dagenham, GB
Alfred P. Spada - Lansdale PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

C07D40102
A61K 3140
A61K 31435

US Classification:

514309

Abstract:

The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibitors. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, which are for treating a patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.