William Fioretti

US Patent:

7527966, May 5, 2009

Filed:

Jun 26, 2003

Appl. No.:

10/609019

Inventors:

Richard K. Cooper - Baton Rouge LA, US
Gary G. Cadd - Grapevine TX, US
William C. Fioretti - Grapevine TX, US
Kenneth F. De Boer - Belgrade MT, US

Assignee:

TransGenRx, Inc. - Baton Rouge LA
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

International Classification:

C12N 15/85
C07H 21/04

US Classification:

4353201, 536 231, 536 241

Abstract:

Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

US Patent:

7608451, Oct 27, 2009

Filed:

Oct 31, 2007

Appl. No.:

11/981574

Inventors:

Richard K. Cooper - Baton Rouge LA, US
Gary G. Cadd - North Attleboro MA, US
William C. Fioretti - Addison TX, US
Kenneth F. De Boer - Rygate MT, US

Assignee:

Transgen Rx, Inc. - Baton Rouge LA
The Board of Supervisors of Louisiana State University and Mechanical College - Baton Rouge LA

International Classification:

C12N 15/85
C07H 21/04
A01K 67/027

US Classification:

4353201, 536 231, 536 241, 800 19

Abstract:

Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

US Patent:

8071364, Dec 6, 2011

Filed:

Dec 24, 2004

Appl. No.:

10/583812

Inventors:

Richard Cooper - Baton Rouge LA, US
Frederick M. Enright - Baton Rouge LA, US
William C. Fioretti - Addison TX, US

Assignee:

TransGenRx, Inc. - Baton Rouge LA
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

International Classification:

C12N 5/00
C12N 15/00
C07H 21/02
C07H 21/04
C07K 2/00

US Classification:

4353201, 435 691, 435325, 435455, 536 231, 536 232, 536 234, 536 2372, 530300

Abstract:

Methods and compositions are presented for the administration of transposon based vectors to an animal or human to provide gene therapy to the animal or human.

US Patent:

8236294, Aug 7, 2012

Filed:

Nov 8, 2010

Appl. No.:

12/941448

Inventors:

Richard K. Cooper - Baton Rouge LA, US
Frederick M. Enright - Baton Rouge LA, US
William C. Fioretti - Addison TX, US

Assignee:

The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA
TransGenRx, Inc. - Baton Rouge LA

International Classification:

A01N 63/00
A61K 48/00
C12N 15/00
C07H 21/04
C07K 1/00

US Classification:

424 932, 424 931, 514 44 R, 4353201, 435455, 536 231, 536 232, 530350

Abstract:

Methods and compositions are presented for the administration of transposon-based vectors to an animal or human to provide gene therapy to the animal or human.

US Patent:

8283518, Oct 9, 2012

Filed:

Oct 31, 2007

Appl. No.:

11/981629

Inventors:

Richard K. Cooper - Baton Rouge LA, US
William C. Fioretti - Grapevine TX, US
Gary G. Cadd - Grapevine TX, US

Assignee:

TransGenRx, Inc. - Baton Rouge LA
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

International Classification:

C12N 15/00
C12P 21/00
A01K 67/027

US Classification:

800 21, 800 4, 800 19

Abstract:

Methods and compositions for the administration of transposon-based vectors to the reproductive organs of animals and the creation of transgenic animals. Preferred methods involve administration of the transposon-based vectors to the lumen of the oviduct of an avian, expression of a vector derived transgene in the avian, and deposition of the resultant polypeptide in an egg. This invention allows for large amounts of protein to be deposited in the egg.

US Patent:

20030171283, Sep 11, 2003

Filed:

Sep 30, 2002

Appl. No.:

10/262581

Inventors:

Daniel Satterlee - Prairieville LA, US
Konstantin Kousoulas - Baton Route LA, US
William Fioretti - Colleyville TX, US

International Classification:

A61K038/17

US Classification:

514/012000

Abstract:

The present invention relates, in general, to a method of enhancing the production performance of avians, by administering to a bird a heterologous protein comprised of inhibin protein, or a fragment thereof, and a carrier protein. The present invention also relates to a method of enhancing the production performance of avians, by administering to a bird a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein. The present invention further relates to the above heterologous protein and fusion gene product, and to methods of producing the same.

US Patent:

20040172667, Sep 2, 2004

Filed:

Dec 24, 2003

Appl. No.:

10/746149

Inventors:

Richard Cooper - Baton Rouge LA, US
William Fioretti - Grapevine TX, US
Gary Cadd - Grapevine TX, US

International Classification:

A01K067/027

US Classification:

800/019000, 800/021000, 119/300000

Abstract:

Methods and compositions for the administration of transposon-based vectors to the reproductive organs of animals and the creation of transgenic animals. Preferred methods involve administration of the transposon-based vectors to the lumen of the oviduct of an avian, expression of a vector derived transgene in the avian, and deposition of the resultant polypeptide in an egg. This invention allows for large amounts of protein to be deposited in the egg.

US Patent:

20040220098, Nov 4, 2004

Filed:

Jan 9, 2004

Appl. No.:

10/755203

Inventors:

Daniel Satterlee - Prairieville LA, US
William Fioretti - Grapevine TX, US
Gary Cadd - Grapevine TX, US

International Classification:

A61K038/27
A01K031/19

US Classification:

514/012000, 119/300000

Abstract:

The present invention relates, in general, to a method of enhancing the fertility and/or growth rate of animals, particularly avians, by administering to a bird a composition comprising a heterologous protein comprising inhibin protein, or a fragment thereof, and a carrier protein, in an acceptable carrier. The present invention also relates to a method of enhancing the fertility and/or growth rate of avians, by administering to a bird a composition comprising a fusion gene product comprising a gene encoded for the expression of alpha-subunit avian inhibin protein, or a fragment thereof, and a gene encoded for the expression of a carrier protein, in an acceptable carrier. An effective amount of the heterologous protein or fusion gene product is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.