William Joseph Flanagan

US Patent:

6352830, Mar 5, 2002

Filed:

Jan 15, 1999

Appl. No.:

09/232346

Inventors:

Gerald R. Crabtree - Woodside CA
Jeffrey P. Northrop - Campbell CA
Steffan N. Ho - San Diego CA
William M. Flanagan - Menlo Park CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

C12Q 168

US Classification:

435 6, 435 4, 435 71, 435 15, 435 21, 536 241, 536 235, 530350

Abstract:

The invention provides novel polypeptides which are associated with the transcription complex NF-AT, polynucleotides encoding such polypeptides, antibodies which are reactive with such polypeptides, polynucleotide hybridization probes and PCR amplification probes for detecting polynucleotides which encode such polypeptides, transgenes which encode such polypeptides, homologous targeting constructs that encode such polypeptides and/or homologously integrate in or near endogenous genes encoding such polypeptides, nonhuman transgenic animals which comprise functionally disrupted endogenous genes that normally encode such polypeptides, and transgenic nonhuman animals which comprise transgenes encoding such polypeptides. The invention also provides methods for detecting T cells (including activated T cells) in a cellular sample, methods for treating hyperactive or hypoactive T cell conditions, methods for screening for immunomodulatory agents, methods for diagnostic staging of lymphocyte differentiation, methods for producing NF-AT proteins for use as research or diagnostic reagents, methods for producing antibodies reactive with the novel polypeptides, and methods for producing transgenic nonhuman animals. Also included are methods and agents for activation of NF-AT dependent transcription, including agents which interfere with the production, modification of nuclear or cytoplasmic subunits, or the nuclear import of the cytoplasmic subunits.

US Patent:

6376524, Apr 23, 2002

Filed:

Jun 21, 2000

Appl. No.:

09/602546

Inventors:

Kenneth J. Barr - San Francisco CA
Brian C. Cunningham - San Mateo CA
William Michael Flanagan - Menlo Park CA
Wanli Lu - Palo Alto CA
Brian C. Raimundo - San Francisco CA
Nathan D. Waal - San Francisco CA
Jennifer Wilkinson - Redwood City CA
Jiang Zhu - San Jose CA
Wenjin Yang - Foster City CA

Assignee:

Sunesis Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A61K 31085

US Classification:

514381, 514617, 514646, 514728, 548250, 548252, 564170, 564174, 568636, 568638, 568643

Abstract:

Triphenyl compounds of the formulae I, II, and VI: methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are compounds are interleukin-4 antagonists; and are useful for the treatment of asthma and allergies.

US Patent:

6572828, Jun 3, 2003

Filed:

Jul 3, 2000

Appl. No.:

09/610001

Inventors:

Radislav Alexandrovich Potyrailo - Niskayuna NY
John Patrick Lemmon - Delanson NY
William Patrick Flanagan - Rexford NY
Roger Neal Johnson - Hagaman NY

Assignee:

General Electric Company - Schenectady NY

International Classification:

B01J 1900

US Classification:

422130, 422 8205, 422 8208, 422 99, 422129, 422131, 436164, 436165, 436172

Abstract:

The present invention is directed to a method and apparatus for rapid screening of potential reactants, catalysts, or associated process conditions. In one embodiment, the method includes the steps of providing a reaction substrate having at least one substrate reservoir and introducing a reactant system at least partially embodied in a liquid into the substrate reservoirs. The reactant system is heated to at least one predetermined temperature. A flow of inert gas is provided through a manifold above the substrate reservoir. The reaction in the substrate reservoir can be monitored, e. g. , visually or spectrophotometrically during the course of the reaction, or the reaction substrate block can be rapidly cooled to stop the reaction in the substrate reservoir prior to analysis.

US Patent:

6693220, Feb 17, 2004

Filed:

Sep 4, 2002

Appl. No.:

10/233720

Inventors:

William Patrick Flanagan - Rexford NY
James Lawrence Spivack - Cobleskill NY
Cheryl Lynn Sabourin - Niskayuna NY

Assignee:

General Electric Company - Niskayuna NY

International Classification:

C07C 3916

US Classification:

568728, 568727

Abstract:

Method for producing multiple chemical reactions and for rapid screening of chemicals, catalysts, process conditions and the like is disclosed. The method includes the steps of providing an array of reactor vessels and reactants; loading each reactor vessel with at least one reactant; and allowing the reactions to proceed for a predetermined time interval. A volume increment is withdrawn from each reactor vessel and a volume increment of at least one reactant is added to each reactor vessel in the array. The steps of volume increment withdrawal and addition are repeated after successive time intervals until the reactions reach a substantially steady state. The loading, withdrawal, and addition steps are performed by liquid or solid handling robots. In one embodiment, the volume increment withdrawal occurs before, after, or contemporaneously with the volume increment addition.

US Patent:

6710212, Mar 23, 2004

Filed:

Jun 26, 2002

Appl. No.:

10/180870

Inventors:

William Patrick Flanagan - Rexford NY
Cheryl Lynn Sabourin - Niskayuna NY
James Lawrence Spivack - Cobleskill NY

Assignee:

General Electric Company - Niskayuna NY

International Classification:

C07C 3916

US Classification:

568728, 568727

Abstract:

A method of producing a chemical reaction is provided. In the practice of one embodiment of the invention, the method includes the steps of providing a reaction vessel and reactants; placing at least one of the reactants in the reaction vessel; and allowing the reaction to proceed for a time interval. A volume increment of at least one of the reactants is withdrawn from the reaction vessel, and a volume increment of at least one of the reactants is added to the reaction vessel. The volume increment withdrawal/addition is repeated after successive time intervals until the reaction reaches a substantially steady state. In various alternative embodiments, the volume increment withdrawal can take place before, after, or contemporaneously with the volume increment addition.

US Patent:

6770482, Aug 3, 2004

Filed:

Jul 3, 2000

Appl. No.:

09/609921

Inventors:

William Patrick Flanagan - Rexford NY
Roger Neal Johnson - Hagaman NY
William Guy Morris - Rexford NY

Assignee:

General Electric - Niskayuna NY

International Classification:

G01N 3110

US Classification:

436 37, 436 43, 422 50, 422 681, 422 81, 422 99, 422130, 422131, 422102, 422103, 422104

Abstract:

In one exemplary embodiment, the present invention is directed to a method that comprises providing a reaction substrate having a plurality of substrate reservoirs adapted to receive a reactant system at least partially embodied in a liquid. A thermal unit maintains the reactant system at a first temperature. A head plate is disposed adjacent to the reaction substrate to form a sealed and pressurized headspace above the substrate reservoirs. The head plate is maintained at a second temperature higher than the first temperature. A second reactant may be introduced as a gas into the headspace above the plurality of substrate reservoirs.

US Patent:

6875571, Apr 5, 2005

Filed:

Jan 7, 2002

Appl. No.:

10/040430

Inventors:

Gerald R. Crabtree - Woodside CA, US
Jeffrey P. Northrop - Campbell CA, US
Steffan N. Ho - San Diego CA, US
William M. Flanagan - Menlo Park CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

C12Q001/68
C07H021/04
G01N033/53
C07K014/435

US Classification:

435 6, 435 4, 435 71, 435 792, 435 15, 435 21, 536 231, 536 235, 530350

Abstract:

The invention provides novel polypeptides which are associated with the transcription complex NF-AT, polynucleotides encoding such polypeptides, antibodies which are reactive with such polypeptides, polynucleotide hybridization probes and PCR amplification probes for detecting polynucleotides which encode such polypeptides, transgenes which encode such polypeptides, homologous targeting constructs that encode such polypeptides and/or homologously integrate in or near endogenous genes encoding such polypeptides, nonhuman transgenic animals which comprise functionally disrupted endogenous genes that normally encode such polypeptides, and transgenic nonhuman animals which comprise transgenes encoding such polypeptides. The invention also provides methods for detecting T cells (including activated T cells) in a cellular sample, methods for treating hyperactive or hypoactive T cell conditions, methods for screening for immunomodulatory agents, methods for diagnostic staging of lymphocyte differentiation, methods for producing NF-AT proteins for use as research or diagnostic reagents, methods for producing antibodies reactive with the novel polypeptides, and methods for producing transgenic nonhuman animals. Also included are methods and agents for activation of NF-AT dependent transcription, including agents which interfere with the production, modification of nuclear or cytoplasmic subunits, or the nuclear import of the cytoplasmic subunits.

US Patent:

20020007093, Jan 17, 2002

Filed:

Dec 4, 2000

Appl. No.:

09/728751

Inventors:

William Flanagan - Rexford NY, US
James Spivack - Cobleskill NY, US
Cheryl Sabourin - Schenectady NY, US

International Classification:

C07C039/16

US Classification:

568/723000

Abstract:

Method for producing multiple chemical reactions and for rapid screening of chemicals, catalysts, process conditions and the like is disclosed. The method includes the steps of providing an array of reactor vessels and reactants; loading each reactor vessel with at least one reactant; and allowing the reactions to proceed for a predetermined time interval. A volume increment is withdrawn from each reactor vessel and a volume increment of at least one reactant is added to each reactor vessel in the array. The steps of volume increment withdrawal and addition are repeated after successive time intervals until the reactions reach a substantially steady state. The loading, withdrawal, and addition steps are performed by liquid or solid handling robots. In one embodiment, the volume increment withdrawal occurs before, after, or contemporaneously with the volume increment addition.