William B Forrest

US Patent:

20070141066, Jun 21, 2007

Filed:

Dec 11, 2006

Appl. No.:

11/609071

Inventors:

Heidi Phillips - Palo Alto CA, US
William Forrest - San Carlos CA, US
Samir Kharbanda - San Francisco CA, US
Thomas Wu - San Francisco CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C12Q 1/68
G01N 33/574
G06F 19/00
A61K 39/395
A61K 33/24

US Classification:

424155100, 435007230, 702019000, 435006000, 424649000

Abstract:

The invention provides generally a method of monitoring, diagnosing, prognosing and treating glioma. Specifically, the invention provides for three (3) prognostic subclasses of glioma, which are differentially associated with activation of the akt and notch signaling pathways. Tumor displaying neural or proneural PN lineage markers (including notch pathway elements) show longer median patient survival, while the two remaining tumor markers Prolif and Mes are associated with shortened survival. Tumors classified in this manner may also be treated with the appropriate PN- Prolif- or Mes-therapeutic corresponding to the subclassification in combination with anti-mitotic agents, anti-angiogenic agents, Akt antagonists, and neural differentiation agents. Alternatively, the invention also provides for method of prognosing and diagnosing glioma with a two-gene model based on the expression levels of PTEN and DLL3.