William H Goddard

US Patent:

7843565, Nov 30, 2010

Filed:

May 29, 2007

Appl. No.:

11/807538

Inventors:

Sheng Wu - San Gabriel CA, US
Andrei Deev - Pasadena CA, US
Steve L. Palm - Escondido CA, US
Yongchun Tang - Walnut CA, US
William A. Goddard - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01N 21/25

US Classification:

356416

Abstract:

A frequency modulated spectroscopy system, including a photo-detector, a band-pass filter to filter the output of the photo-detector, and a rectifier to demodulate. The band-pass filter has a relatively high Q factor. With the high Q factor band-pass filter and rectifier, a reference sinusoid is not required for demodulation, resulting in phase-insensitive spectroscopy. Other embodiments are described and claimed.

US Patent:

7858720, Dec 28, 2010

Filed:

Jun 19, 2007

Appl. No.:

11/820472

Inventors:

Margaret A. Ryan - Pasadena CA, US
Margie L. Homer - Pasadena CA, US
Adam Kisor - Pasadena CA, US
April D. Jewell - Somerville MA, US
Abhijit V. Shevade - Altadena CA, US
Kenneth S. Manatt - Tujunga CA, US
Charles Taylor - Claremont CA, US
Mario Blanco - Temple City CA, US
William A. Goddard - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C08F 126/06

US Classification:

526263, 526265, 526346, 526347

Abstract:

Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed.

US Patent:

8187865, May 29, 2012

Filed:

May 29, 2009

Appl. No.:

12/455186

Inventors:

Minhee Yun - La Crescenta CA, US
Nosang Myung - Rosemead CA, US
Richard Vasquez - Altadena CA, US
Margie Homer - Pasadena CA, US
Margaret Ryan - Pasadena CA, US
Jean-Pierre Fleurial - Altadena CA, US
Ratnakumar Bugga - Arcadia CA, US
Daniel Choi - Los Angeles CA, US
William Goddard - Pasadena CA, US
Abhijit Shevade - Pasadena CA, US
Mario Blanco - Temple City CA, US
Tahir Cagin - Arcadia CA, US
Wely Floriano - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12M 1/34
C12M 3/00

US Classification:

4352872, 977762, 422 681, 422 8201, 422 8202, 4352831, 4352871, 4352883

Abstract:

The present invention relates to a nanowire sensor and method for forming the same. More specifically, the nanowire sensor comprises at least one nanowire formed on a substrate, with a sensor receptor disposed on a surface of the nanowire, thereby forming a receptor-coated nanowire. The nanowire sensor can be arranged as a sensor sub-unit comprising a plurality of homogeneously receptor-coated nanowires. A plurality of sensor subunits can be formed to collectively comprise a nanowire sensor array. Each sensor subunit in the nanowire sensor array can be formed to sense a different stimulus, allowing a user to sense a plurality of stimuli. Additionally, each sensor subunit can be formed to sense the same stimuli through different aspects of the stimulus. The sensor array is fabricated through a variety of techniques, such as by creating nanopores on a substrate and electrodepositing nanowires within the nanopores.

US Patent:

8338552, Dec 25, 2012

Filed:

Nov 16, 2010

Appl. No.:

12/947598

Inventors:

Margaret A. Ryan - Pasasdena CA, US
Margie L. Homer - Pasadena CA, US
Adam Kisor - Pasadena CA, US
April D. Jewell - Somerville MA, US
Abhijit V. Shevade - Altadena CA, US
Kenneth S. Manatt - Tujunga CA, US
Charles Taylor - Claremont CA, US
Mario Blanco - Temple City CA, US
William A. Goddard - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C08F 26/06
C08F 126/06

US Classification:

526260, 526265

Abstract:

Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is polystyrene and the second monomer is poly-2-vinyl pyridinium propylamine chloride. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the second monomer is poly-4-vinyl pyridinium benzylamine chloride. Other embodiments are described and claimed.

US Patent:

8370074, Feb 5, 2013

Filed:

Oct 27, 2009

Appl. No.:

12/606605

Inventors:

Rene J. Trabanino - Los Angeles CA, US
Nagarajan Vaidehi - Arcadia CA, US
Spencer E. Hall - Tucson AZ, US
William A. Goddard - Pasadena CA, US
Wely Floriano - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01N 33/48
C12Q 1/68
G06G 7/58
G06F 7/60

US Classification:

702 19, 435 6, 702 20, 703 2, 703 11, 700 90

Abstract:

The invention provides computer-implemented methods and apparatus implementing a hierarchical protocol using multiscale molecular dynamics and molecular modeling methods to predict the presence of transmembrane regions in proteins, such as G-Protein Coupled Receptors (GPCR), and protein structural models generated according to the protocol. The protocol features a coarse grain sampling method, such as hydrophobicity analysis, to provide a fast and accurate procedure for predicting transmembrane regions. Methods and apparatus of the invention are useful to screen protein or polynucleotide databases for encoded proteins with transmembrane regions, such as GPCRs.

US Patent:

8481421, Jul 9, 2013

Filed:

Jul 24, 2008

Appl. No.:

12/179345

Inventors:

William A. Goddard - Pasadena CA, US
Weiqiao Deng - Pasadena CA, US
Yuki Matsuda - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

H01L 21/4763

US Classification:

438618

Abstract:

Functional linkers or anchors interconnecting graphene-like carbon, such as nanotubes or graphite sheets, with a conducting material such as a metal, are shown, together with related structures, devices, methods and systems.

US Patent:

20020099506, Jul 25, 2002

Filed:

Nov 30, 2001

Appl. No.:

10/010725

Inventors:

Wely Floriano - Pasadena CA, US
Nagarajan Vaidehi - Arcadia CA, US
William Goddard - Pasadena CA, US

International Classification:

G06G007/48
G06G007/58
G06F019/00
G01N033/48
G01N033/50

US Classification:

702/019000, 703/011000

Abstract:

Computer-implemented methods and apparatus implement a hierarchy of molecular modeling techniques for predicting binding sites of ligands in proteins, designing new pharmaceuticals and understanding the interactions of proteins involved in microbial pathogens. The techniques employ a hierarchical strategy ranging from coarse grain to fine grain conformational search methods combined with hierarchical levels of accuracy in scoring functions.

US Patent:

20020188373, Dec 12, 2002

Filed:

Mar 28, 2002

Appl. No.:

10/113919

Inventors:

William Goddard - Pasadena CA, US
Gyeong Hwang - Austin TX, US

International Classification:

B29C045/00

US Classification:

700/200000

Abstract:

Computer programs and computer-implemented methods for predicting from first principles the behavior of dopants and defects in the processing of electronic materials. The distribution of dopant and defect components in a substrate lattice is predicted based on external conditions and fundamental data for a set of microscopic processes that can occur during material processing operations. The concentration behavior of one or more fast components is calculated in two stages, by solving a first relationship for a time period before the fast component reaches a pseudo steady state at which the concentration of the fast component is determined by concentrations of one or more second components, and by solving a second relationship for a time period after the first component reaches the pseudo steady state. Application of these methods to modeling ultrashallow junction processing is also described.