William R Nicholson

Address:

4822 Wildrose Ct NW, Kennesaw, GA 30152

Phone:

7707233720

VIN:

19UUA8F74CA039062

Make:

ACURA

Model:

TL

Year:

2012

US Patent:

20150086577, Mar 26, 2015

Filed:

Mar 22, 2013

Appl. No.:

14/386923

Inventors:

- Bethesda MD, US
Cynthia Goldsmith - Lilburn GA, US
Aubree Kelly - Atlanta GA, US
William L. Nicholson - Atlanta GA, US
Stuart T. Nichol - Atlanta GA, US

Assignee:

The Government of the United States of America as represented by the Secretary of the Department of - Bethesda MD

International Classification:

A61K 39/12
G01N 33/569
C12Q 1/70
C12N 7/00

US Classification:

4241861, 4352351, 530350, 536 2372, 4353201, 536 2432, 5303879, 435 5, 435325

Abstract:

Described herein are the clinical and laboratory characteristics of two patients bitten by ticks and infected with a unique member of the genus Phlebovirus (family Bunyaviridae) with a proposed name of Heartland virus (HRTLV). Provided herein are nucleotide and amino acid sequences of the Phlebovirus isolates, primers and probes that specifically hybridize with the Phlebovirus isolates, and antibodies specific for the Phlebovirus proteins. Also provided are detection assays using the Phlebovirus nucleic acid molecules, proteins, probes, primers and antibodies. Further provided are recombinant Phleboviruses and their use for eliciting an immune response in a subject.